Results 31 to 40 of about 13,374 (270)
Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication. [PDF]
FASEB JThe schematic illustration of PARG‐mediated dePARylation in DNA replication. In the normal physiological condition, PARG functions as an eraser to remove PAR from PCNA and promote the interaction between FEN1 and PCNA (A). Interruption of PARG results in the accumulation of PARs in DNA replication sites, represses the interaction between PCNA and FEN1,
Yan Z +11 more
europepmc +2 more sources
In-silico evaluation of natural alkaloids against the main protease and spike glycoprotein as potential therapeutic agents for SARS-CoV-2. [PDF]
PLoS ONESevere Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is the causative agent of COVID-19 pandemic, which has resulted in global fatalities since late December 2019.
Mohibullah Shah +11 more
doaj +2 more sources
Integrated Genomic and GEO Data Analysis Reveals Therapeutic Targets for Rosacea. [PDF]
J Cosmet DermatolABSTRACT Background Rosacea is a chronic inflammatory facial disorder with limited therapeutic options, severely impacting patients' quality of life. The identification of druggable genes plays a crucial role in facilitating the development of effective therapeutic strategies.
Deng X, He S, Long H, Xiao J, Xie Z.
europepmc +2 more sources
Cancer Chemotherapy and Pharmacology, 2023 Background Gastric cancer (GC) is a life-threatening malignant tumor with high incidence rate. Despite great progress, there are still many GC sufferers that cannot benefit from the existing anti-GC treatments. Therefore, it is still necessary to develop
Xuerun Peng +5 more
semanticscholar +1 more source
Emetine dihydrochloride alleviated radiation‐induced lung injury through inhibiting EMT
Journal of Cellular and Molecular Medicine, 2023 Radiation‐induced lung injury (RILI), divided into early radiation pneumonia (RP) and late radiation‐induced pulmonary fibrosis (RIPF), is a common serious disease after clinical chest radiotherapy or nuclear accident, which seriously threatens the life ...
Xin Wang +9 more
semanticscholar +1 more source
Natural Product Research, 2023 This study evaluated the responses of Carapichea ipecacuanha to sunlight stress-induced changes in the electron transport chain and its extended effects on alkaloid production (emetine and cephalin). The treatments consisted of: (i).
Cristina Moll Hüther +14 more
semanticscholar +1 more source
Сибирский онкологический журнал, 2022 Objective: screening of previously selected DDIT4 inhibitors by their ability to suppress basal and glucocorticoid-induced expression of this gene in breast cancer (BC) cells, as well as evaluation of antiproliferative and cytotoxic effects of the ...
E. M. Zhidkova +9 more
doaj +1 more source
Different Aspects of Emetine’s Capabilities as a Highly Potent SARS-CoV-2 Inhibitor against COVID-19
ACS Pharmacology & Translational Science, 2022 In the global movement to find the appropriate agents to fight the coronavirus disease of 2019 (COVID-19), emetine is one of the strongest anti-SARS-CoV-2 compounds with sub-micromolar EC50 values, identified in several studies and high-throughput ...
Mehdi Valipour
semanticscholar +1 more source
Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients. [PDF]
PLoS ONE, 2013 Although quantitative and qualitative granulocyte defects have been described in myelodysplastic syndromes (MDS), the underlying molecular basis of granulocyte dysfunction in MDS is largely unknown.
Xiaomin Feng +8 more
doaj +1 more source
Cells, 2022 Chloroquine and Emetine are drugs used to treat human parasitic infections. In addition, it has been shown that these drugs have an antiviral effect.
Pavel Spirin +4 more
doaj +1 more source