Results 31 to 40 of about 13,194 (271)

Emetine dihydrochloride alleviated radiation‐induced lung injury through inhibiting EMT

Journal of Cellular and Molecular Medicine, 2023
Radiation‐induced lung injury (RILI), divided into early radiation pneumonia (RP) and late radiation‐induced pulmonary fibrosis (RIPF), is a common serious disease after clinical chest radiotherapy or nuclear accident, which seriously threatens the life ...
Xin Wang, Mo Li, Jizhong Yin, Jiayan Fang, Yimeng Ying, Tianxia Ye, Fangxiao Zhang, Shumei Ma, Hongran Qin, Xiaodong Liu   +9 more
semanticscholar   +1 more source

Alkaloids (emetine and cephalin) production – affected by full sunlight stress in Carapichea ipecacuanha

Natural Product Research, 2023
This study evaluated the responses of Carapichea ipecacuanha to sunlight stress-induced changes in the electron transport chain and its extended effects on alkaloid production (emetine and cephalin). The treatments consisted of: (i).
Cristina Moll Hüther, V. F. Ferreira, Fernando de Carvalho da Silva, W. da Costa Santos, J. Borella, Ramonn Diego Barros de Almeida, D. Correia, G. C. A. Duarte, A. Langaro, Julia Ramos de Oliveira, Jóice Azeredo Silva, T. Machado, C. F. de Pinho, F. Reinert, C. R. Pereira   +14 more
semanticscholar   +1 more source

In vitro screening of effectiveness and antiproliferative effects of potential DDIT4 inhibitors for breast cancer cell lines

Сибирский онкологический журнал, 2022
Objective: screening of previously selected DDIT4 inhibitors by their ability to suppress basal and glucocorticoid-induced expression of this gene in breast cancer (BC) cells, as well as evaluation of antiproliferative and cytotoxic effects of the ...
E. M. Zhidkova, D. D. Grigoreva, E. S. Lylova, V. P. Maksimova, G. R. Sagitova, G. I. Khayrieva, E. S. Trapeznikova, K. I. Kirsanov, M. G. Yakubovskaya, E. A. Lesovaya   +9 more
doaj   +1 more source

Different Aspects of Emetine’s Capabilities as a Highly Potent SARS-CoV-2 Inhibitor against COVID-19

ACS Pharmacology & Translational Science, 2022
In the global movement to find the appropriate agents to fight the coronavirus disease of 2019 (COVID-19), emetine is one of the strongest anti-SARS-CoV-2 compounds with sub-micromolar EC50 values, identified in several studies and high-throughput ...
Mehdi Valipour
semanticscholar   +1 more source

Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients. [PDF]

PLoS ONE, 2013
Although quantitative and qualitative granulocyte defects have been described in myelodysplastic syndromes (MDS), the underlying molecular basis of granulocyte dysfunction in MDS is largely unknown.
Xiaomin Feng, Yayoi Shikama, Tsutomu Shichishima, Hideyoshi Noji, Kazuhiko Ikeda, Kazuei Ogawa, Hideo Kimura, Yasuchika Takeishi, Junko Kimura   +8 more
doaj   +1 more source

Plant Hormone Cytokinin as Aggregation Modulator of Gelsolin Amyloidosis. [PDF]

J Pept Sci
Gelsolin peptides form amyloids, and aggregation is accelerated by a single point mutation. The gelsolin amyloids can be inhibited using plant hormones. ABSTRACT Amyloidosis, a self‐assembly of proteins or peptides, is associated with numerous degenerative diseases, such as gelsolin amyloidosis, which remain without a cure. Gelsolin protein is an actin‐
Seneviratne D, Stock N, Lewis T, Emery RJN, Martic S.   +4 more
europepmc   +2 more sources

Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles

Cells, 2022
Chloroquine and Emetine are drugs used to treat human parasitic infections. In addition, it has been shown that these drugs have an antiviral effect.
Pavel Spirin, Elena Shyrokova, Valeria Vedernikova, Timofey Lebedev, Vladimir Prassolov   +4 more
doaj   +1 more source

Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments

Life Science Alliance, 2022
This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis.
D. Lukac, Z. Macháčová, Pavel Moudry
semanticscholar   +1 more source

THE PHARMACOLOGY OF EMETIN [PDF]

The American Journal of the Medical Sciences, 1916
n ...
Pellini, Emil J., Wallace, George B.
openaire   +2 more sources

Emetine and Indirubin- 3- monoxime interaction with human brain acetylcholinesterase: A computational and statistical analysis.

Cellular and Molecular Biology, 2022
Alzheimer's disease is a chronic neurodegenerative ailment and the most familiar type of dementia in the older population with no effective cure to date.
S. Ahmad, Haroon Khan, Mohammad Khalid, Abdulraheem S. A. Almalki   +3 more
semanticscholar   +1 more source