Synthesis of substituted allyl acetates from heterocyclic dienes by Pd-promoted arylation-acetoxylation cascade [PDF]
Journal of the Serbian Chemical Society, 2017 Pd-catalysed arylation–acetoxylation cascade, a previously reported methodology, was applied in the functionalisation of unsymmetrical dienes. Both explored classes of compounds, isoquinoline and β-carboline-derived dienes, afforded single regioisomers ...
Simić Milena R. +4 more
doaj +1 more source
ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells [PDF]
, 2010 Doxorubicin is an anthracycline drug that is one of the most effective and widely used anticancer agents for the treatment of both hematologic and solid tumors.
Bruce E. Magun +6 more
core +2 more sources
Metabolic properties of the products of mitochondrial protein synthesis in HeLa cells [PDF]
, 1977 The metabolic behavior of the mitochondrial protein synthesis products has been investigated in HeLa cells. Particular attention was given to the four major electrophoretic components (designated as Nos. 2, 3, 5, and 8) of the 10 previously identified as
Attardi, Giuseppe, Costantino, Paolo
core
Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line [PDF]
, 2009 Background: Using array comparative genomic hybridization (aCGH), a large number of deleted genomic regions have been identified in human cancers. However, subsequent efforts to identify target genes selected for inactivation in these regions have often ...
Dejeux, Emelyne +7 more
core +2 more sources
Plant Hormone Cytokinin as Aggregation Modulator of Gelsolin Amyloidosis
Journal of Peptide Science, Volume 31, Issue 10, October 2025.Gelsolin peptides form amyloids, and aggregation is accelerated by a single point mutation. The gelsolin amyloids can be inhibited using plant hormones. ABSTRACT Amyloidosis, a self‐assembly of proteins or peptides, is associated with numerous degenerative diseases, such as gelsolin amyloidosis, which remain without a cure. Gelsolin protein is an actin‐
Dev Seneviratne +4 more
wiley +1 more source
Distinctive pattern and translational control of mitochondrial protein synthesis in rat brain synaptic endings [PDF]
, 1991 Mitochondrial gene expression has been investigated in synaptic endings from rat cerebral cortex isolated at various stages during the postnatal development and maturation of the animal.
Attardi, Giuseppe +1 more
core
Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, Volume 20, Issue 18, September 25, 2025.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
New drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing. [PDF]
PLoS ONE, 2018 Atypical meningiomas are common central nervous system neoplasms with high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical excision and radiotherapy remains the mainstay therapy but medical treatments are limited. We
Zsolt Zador +2 more
doaj +1 more source
Expression of the Mitochondrial Genome in HeLa Cells. XV. Effect of Inhibition of Mitochondrial Protein Synthesis on Mitochondrial Formation [PDF]
, 1973 The effect of selective inhibition of mitochondrial protein synthesis by chloramphenicol at 40 or 200 µg/ml on the formation of mitochondria in HeLa cells was investigated.
Attardi, Giuseppe, Storrie, Brian
core
Oncology Report, 2019 Emetine, an amoebicidal drug, exerts potent anticancer activity against various solid tumors, however, the underlying molecular mechanism remains unclear.
Qi Sun +8 more
semanticscholar +1 more source