EMETINE MYOPATHY IN THE RAT [PDF]
British Journal of Pharmacology, 1976 (–)‐Emetine (0.25‐2.0 mg/kg i.p.) was administered to rats for up to 220 days. At doses of 1.0 mg/kg or less, the animals continued to gain weight but more slowly than the untreated control animals. The physiological changes in the muscles from these animals were minimal; there was a small reduction in both the resting membrane potential and in the ...
Walter G. Bradley +3 more
openaire +3 more sources
Interaction with the cysteine-free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation. [PDF]
FEBS JThe mitochondrial disulphide relay machinery is essential for the import and oxidative folding of many proteins in the mitochondrial intermembrane space. MIA40 is a core component of this machinery, and after non‐covalent interaction, it introduces disulphide bonds into its substrates.
Rothemann RA +11 more
europepmc +2 more sources
Frontiers in Cellular and Infection Microbiology, 2017 Transcriptional regulation of the multidrug resistance EhPgp5 gene in Entamoeba histolytica is induced by emetine stress. EhPgp5 overexpression alters the chloride-dependent currents that cause trophozoite swelling, diminishing induced programmed cell ...
Alma Nieto +4 more
doaj +1 more source
Informatics in Medicine Unlocked, 2022 Mucormycosis has become a global issue due to its potential to infect and destroy organs, as well as its high fatality rate. Co-infecting with Covid 19 or when infecting after Covid 19, it becomes more lethal.
Anik Banik +5 more
doaj +1 more source
The role of cyclin synthesis, modification and destruction in the control of cell division [PDF]
, 1989 This paper reviews our current knowledge of the cyclins based on observations of the oocytes and eggs of sea urchins, clams and frogs. Cyclins are proteins found in all eukaryotes whose special property is rapid destruction at specific stages in the cell
Blow, J. +9 more
core +2 more sources
Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles. [PDF]
PLoS ONE, 2015 Small molecule based therapeutic intervention of amyloids has been limited by their low solubility and poor pharmacokinetic characteristics. We report here, the use of water soluble poly lactic-co-glycolic acid (PLGA)-encapsulated curcumin and emetine ...
Ankit Srivastava +5 more
doaj +1 more source
ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells [PDF]
, 2010 Doxorubicin is an anthracycline drug that is one of the most effective and widely used anticancer agents for the treatment of both hematologic and solid tumors.
Bruce E. Magun +6 more
core +2 more sources
Synthesis of substituted allyl acetates from heterocyclic dienes by Pd-promoted arylation-acetoxylation cascade [PDF]
Journal of the Serbian Chemical Society, 2017 Pd-catalysed arylation–acetoxylation cascade, a previously reported methodology, was applied in the functionalisation of unsymmetrical dienes. Both explored classes of compounds, isoquinoline and β-carboline-derived dienes, afforded single regioisomers ...
Simić Milena R. +4 more
doaj +1 more source
Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line [PDF]
, 2009 Background: Using array comparative genomic hybridization (aCGH), a large number of deleted genomic regions have been identified in human cancers. However, subsequent efforts to identify target genes selected for inactivation in these regions have often ...
Dejeux, Emelyne +7 more
core +2 more sources
Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory [PDF]
, 2013 Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing.
Cammarota, Martin Pablo +4 more
core +3 more sources