ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
IMPLEMENTASI IMPORTANCE AND PERFORMANCE ANALYSIS (IPA) DALAM PELAKSANAAN PENILAIAN KINERJA KARYAWAN (PNS) (Studi pada Kementerian Pekerjaan Umum Dan Perumahan Rakyat, SNVT PJPA Pemali-Juana PPK PAT dan PPK PAB) [PDF]
, 2017 This study aims to examine the implementation of performance appraisal at the Ministry of Public Works and Public Housing, SNVT PJPA Pemali-Juana PPK PAT and PPK PAB.
NUGRAHA, Nur Chaida, YUNIAWAN , Ahyar
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
SO, DID YOU DEVELOP YOUR COMPETENCE? The influence of performance appraisals on employees’ competence development [PDF]
, 2012 This study focuses on the qualitative aspect of employee’s competence development that is of critical importance to both employee and organizational development.
Wenestam, Codine
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Competitive Strategy, Performance Appraisal and Firm Results
, 2016 In this study, we address the relationship between performance appraisal and competitive strategy, as well as the impact of this relationship on firm performance.
Bayo-Moriones, Alberto +2 more
core
The Impact of Performance Appraisal, Reward System, Job Stress, and Work Life Conflict to Employee Performance [PDF]
, 2014 Employee Performance is an important part in a company or organization. It plays a very important role in an organization because performance of the company or organization largely depends on the performance of its employee.
Rumambie, Y. F. (Yuliana)
core