Results 111 to 120 of about 192,258 (260)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Employee Performance Management: Implementation of Assessment System to Improve Organizational Effectiveness

Indonesian Interdisciplinary Journal of Sharia Economics
This study aims to analyze the implementation of the employee performance appraisal system in the roof tile industry in Majalengka Regency, with a focus on identifying factors that influence the effectiveness of the performance appraisal system and its ...
Siswayu Gamar Maulida, Dewi Sri Yani, Editya Nurdiana   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Determinants Factors Turnover Intention of Employees In Trading and Furniture Manufacture Company

Bulletin of Counseling and Psychotherapy
In the workplace, workers are crucial to the accomplishment of organizational objectives. As a result, it is critical for businesses to comprehend the variables that may affect employee retention.
Brisha Savira, Mohammad Annas, Hendy Tannady   +2 more
doaj   +1 more source

Pengaruh Penilaian Kinerja Karyawan Dan Reward Terhadap Prestasi Kerja Karyawan Pada Hotel Sapadia Pasir Pengaraian [PDF]

, 2017
Sapadia Hotel is a three-star hotel (***) in Pasir Pengaraian and located jl.Tuanku Tambusai FOUR intersection Km.4 LGs, Pematang Berangan,Pasir Pengaraian, Rokan Hulu. Sapadia Hotels to exercise employee performance evaluation and reward.
Siregar, N. T. (Neni), Suryalena, S. (Suryalena)   +1 more
core  

Employee Performance Appraisal in Business [PDF]

Proceedings of the The First International Conference On Islamic Development Studies 2019, ICIDS 2019, 10 September 2019, Bandar Lampung, Indonesia, 2019
Mohammad Ghozali, Hamid Zarkasyi, Kurnia Jayanti, Yunita Wulandari   +3 more
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Job Satisfaction of the Employees in the Mobile Phone Corporates in Bangladesh: A Case Study [PDF]

Optimizing employee satisfaction is a key to the success of any business that relies on a variety of organizational and psycho-economic factors. This study was conducted to identify that sort of key factors, which are responsible to influence on the ...
Mohammad A. Ashraf, Mohammad M. H. R. Joarder, R. Al-Masum   +2 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source