Results 141 to 150 of about 192,258 (260)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Effects of Dyadic Quality and Duration on Performance Appraisal

open access: yesJISR Management and Social Sciences & Economics, 2009
Performance evaluation is one of the fundamental tasks that have to be accomplished by an organization. It is a process through which the employee’s performance is evaluated and on the basis of which different decisions are taken.
Ayesha Amanullah Khan, Syed Tahir Hijazi
doaj  

Employee perceptions of performance appraisal

open access: yes, 2018
Aiempi tutkimus on jo pidemmän aikaa osoittanut yhteyden henkilöstöjohtamisen ja suorituksen välillä, mutta kysymys siitä miten tämä yhteys muodostuu, on jäänyt vähemmälle huomiolle. Bowen ja Ostroff (2004) ovat esittäneet, että työntekijöiden tulkitessa henkilöstöjohtamisen prosessit yhtenäisesti, syntyy vahva organisaatioilmasto.
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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