Results 131 to 140 of about 1,588,043 (289)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
The Effects of Minimum Wages on Employment: Theory and Evidence from the US [PDF]
Recent work on the economic effects of minimum wages has stressed that the standard economic model, where increases in minimum wages depress employment, is not supported by the empirical findings in some labour markets.
Alan Manning +2 more
core
Work and well-being over time: lone mothers and their children [PDF]
, 2008 This report provides findings from the third wave of a qualitative longitudinal study, which began in 2003, following a sample of lone mothers who elected to move into employment supported by tax credits following a period of unemployment in receipt of ...
Millar, Jane., Ridge, Tess
core
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Supported Employement: Recommendations for successful implementation in South Africa
South African Journal of Occupational Therapy, 2011 Introduction: This article reports on the findings of a descriptive qualitative study in which supported employment (SE), as a potential strategy to facilitate the employment of persons with disability in the open labour market in South Africa, was ...
Lana van Niekerk +6 more
doaj
, 2010 Art?culo para la "International Encyclopedia of Rehabilitation" que est? desarrollando en un proyecto internacional el Center for International Rehabilitation Research Information and Exchange (CIRRIE), de la Universidad de Buffalo, y el Laboratoire d?informatique et de terminologie de la r?adaptation et de l?int?gation sociale (LITRIS), del Institut ...
openaire +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Predicting Employment Effects of Job Coaching [PDF]
, 2007 Providing employment-related services, including supported employment through job coaches, to individuals with developmental disabilities has been a priority in federal policy for the past twenty years starting with the Developmental Disabilities ...
Mann, Joshua +3 more
core +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source