Results 231 to 240 of about 86,276 (266)
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Enantiomer specific pharmacokinetics
Pharmacology & Therapeutics, 1990To indicate the extent of differences in the pharmacokinetics of enantiomers with respect to absorption and disposition phenomena. To emphasise the potential benefits of studying enantiospecific pharmacokinetics, that is, kinetics based on the measurement of the time-course of separate isomers rather than of the total, racemic drug ...
G T, Tucker, M S, Lennard
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Enantiomer–enantiomer interaction of ifosfamide in the rat
Xenobiotica, 2006The objective of this study was to study the enantiomer-enantiomer interaction of ifosfamide (IFA) in a rat model. Following intravenous administration of individual IFA enantiomers or pseudo-racemates to male Sprague-Dawley rats, two enantiomers and their metabolites, 4-hydroxyIF (HOIF), N2-dechloroethylIF (N2D), N3-dechloroethylIF (N3D), and ...
H, Lu, J J, Wang, K K, Chan
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Chromatographic separation of enantiomers
Pharmaceutisch Weekblad Scientific Edition, 1988In this paper a review is presented on the chromatographic analysis of enantiomers with special attention to high pressure liquid chromatography. Also, some examples of resolution of racemates by thin layer chromatography and gas chromatography are given.
K G, Feitsma, B F, Drenth
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The Journal of Membrane Biology, 2004
Cholesterol plays a variety of significant roles in biological systems. However, the mechanisms by which cholesterol functions remain largely unclear. The enantiomer of cholesterol (ent-cholesterol)--which has identical physical properties, but opposite three-dimensional configuration compared to cholesterol--is a unique tool that can be used to better
E J, Westover, D F, Covey
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Cholesterol plays a variety of significant roles in biological systems. However, the mechanisms by which cholesterol functions remain largely unclear. The enantiomer of cholesterol (ent-cholesterol)--which has identical physical properties, but opposite three-dimensional configuration compared to cholesterol--is a unique tool that can be used to better
E J, Westover, D F, Covey
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Stochastic Detection of Enantiomers
Journal of the American Chemical Society, 2006The rapid quantification of the enantiomers of small chiral molecules is very important, notably in pharmacology. Here, we show that the enantiomers of drug molecules can be distinguished by stochastic sensing, a single-molecule detection technique.
Xiao-Feng, Kang +3 more
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Biotransformation of deprenyl enantiomers
European Journal of Drug Metabolism and Pharmacokinetics, 1999Rats were treated with either (-)- or (+)-deprenyl, and the metabolites extracted from the plasma, liver, kidney and heart homogenates were studied by chiral capillary electrophoresis (CE). Stereoselective dealkylation of both optical isomers with the formation of desmethyldeprenyl (DD), methamphetamine (MA), and amphetamine (A) was found.
E, Szökö, H, Kalász, K, Magyar
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Ketamine enantiomers and acetylcholinesterase
Biochemical Pharmacology, 1991(-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. In most cases the difference was small but for two rate constants the (-)-form was unique in having effects. Thus, the stereoselectivity of ketamine in this system is the opposite of most other systems studied.
G, Puu, M, Koch, E, Artursson
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Sympathomimetic enantiomers and asthma
Chirality, 1998Airways of asthma patients can become hyperresponsive to airway spasmogens following regular use of isoprenaline or beta 2-selective sympathomimetics. Hyper-reactivity that results from acute exposure of animals to these drugs is pre-empted by vagal section (a procedure which does not influence spasmolytic efficacy of sympathomimetics), is not ...
D A, Handley +3 more
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CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS
Chemical Engineering Communications, 1998Abstract In the pharmaceutical industry, the increasing demand of new single enantiomer products has raised a great interest towards chromatographic separation methods. While analytical applications of high performance liquid chromatography and gas chromatography are well established, the scaling up to preparative applications still needs a better ...
MAZZOTTI, MARCO GIUSEPPE +5 more
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Resolution of aristeromycin enantiomers
Journal of Medicinal Chemistry, 1985L'activite biologique des analogues carbocycliques de l'adenosine et de l'adenosine monophosphate peut etre attribuee exclusivement a la presence de l'enantiomere(−) dans les melanges ...
P, Herdewijn +3 more
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