Results 151 to 160 of about 119,652 (298)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Enantio- and Site-Selective Synthesis of α-Substituted Hydrazines, Pyrazolidines, and Tertiary Alcohols by Copper-Catalyzed Allylic C-N and C-O Bond Formation. [PDF]

J Am Chem Soc
Johnson BE, Hughes GM, Wheatley E, Meek SJ.   +3 more
europepmc   +1 more source

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, EarlyView.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source

Electrochemical Oxidative Dihydrobenzofuran Synthesis

ChemElectroChem, Volume 13, Issue 10, 19 May 2026.
Dihydrobenzofurans are accessed under oxidative electrochemical conditions either starting from phenol‐based ketones or β‐ketolactones. We herein report the synthesis of dihydrobenzofurans via an oxidative cycloetherification process under electrochemical conditions.
David Pollheimer, Maximilian Radetzky, Mario Waser   +2 more
wiley   +1 more source

Nickel‐Catalyzed Enantioconvergent Arylation of Unactivated Cyclic Electrophiles: Asymmetric Synthesis of 3‐Substituted Pyrrolidines

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
Metal‐catalyzed enantioconvergent substitutions of unactivated cyclic electrophiles by organometallic nucleophiles have not previously been reported. Herein, a chiral nickel catalyst is described that achieves this objective, coupling 3‐iodopyrrolidine derivatives with arylzinc nucleophiles.
Ting Hei Matthew Wong, Xiaoyu Tong, Gregory C. Fu   +2 more
wiley   +2 more sources

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

The effect of substituents of immobilized Rh complexes on the asymmetric hydrogenation of acetophenone derivatives

Open Chemistry, 2008
Zsigmond Ágnes, Undrala Suhsen, Notheisz Ferenc, Szöllősy Áron, Bakos József   +4 more
doaj   +1 more source

Recent developments in the organocatalytic asymmetric cycloaddition/annulation reactions involving indolylmethanols. [PDF]

RSC Adv
Patel A, Harshit, Iype E, Kumar I.
europepmc   +1 more source

Asymmetric Reduction of Unactivated Alkenes

Chemistry – A European Journal, Volume 32, Issue 18, 14 May 2026.
Unactivated alkenes rank among the most inert functional groups in synthesis and their selective reduction remains challenging. This Review charts the evolution from classical metal‐catalyzed hydrogenation to radical hydrogen atom transfer (HAT) and emerging biocatalytic concepts, highlighting how complementary mechanistic strategies, including the ...
Nico D. Fessner, Sebastian Roth, Richard Niese, Michael Müller   +3 more
wiley   +1 more source

Enantioselective electrophilic α-fluorination catalyzed by an artificial metalloenzyme. [PDF]

Chem Sci
Yu J, Wang C, Hu W, Wang H, Zhao J, Pan HJ.   +5 more
europepmc   +1 more source