Results 171 to 180 of about 119,652 (298)

Enantioselective C-H functionalization: logic and applications in the total synthesis of natural products. [PDF]

Chem Sci
Qian PF, Shi BF.
europepmc   +1 more source

Catalytic Enantioselective Synthesis of Conformationally Stable C(sp2)−C(sp3) Naphthocoumarin Atropisomers

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
The enantioselective synthesis of naphthocoumarin adducts via a tandem organocatalytic 1,4‐addition/decarboxylation delivers excellent control over a newly forged stereocenter and yields configurationally stable synclinal atropisomers. The process features broad substrate scope and scalability, and its structural and mechanistic foundations are ...
M. Chiara Cabua, Davide Moi, Emanuele Cocco, Valentina Onnis, Enrico Podda, David J. Aitken, Armando Carlone, Renzo Luisi, Enrica Tuveri, Drew F. Parsons, Francesco Secci   +10 more
wiley   +1 more source

Recent advances in the stereoselective synthesis of distal biaxially chiral molecules. [PDF]

Beilstein J Org Chem
Zhou F, Zhang C, Sun L, Fang Y, Zheng S, Hu L, Shen M, Zhao Z, Xu W, Sun Y, Rong ZQ.   +10 more
europepmc   +1 more source

Desymmetrization of Pseudo‐para Diformyl[2.2]Paracyclophane via Brønsted Acid‐Catalyzed Reductive Amination

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
A highly stereoselective desymmetrization of pseudo‐para diformyl[2.2]paracyclophanes is developed via chiral Brønsted acid‐catalyzed reductive amination. This protocol provides efficient access to enantiopure planar chiral paracyclophanes with broad substrate scope, excellent enantioselectivity, and versatile postsynthetic functionalization. Access to
Sandip Baban Shinde, Martin Kamlar, Vojtěch Dočekal, Ivana Císařová, Jan Veselý   +4 more
wiley   +1 more source

Transition Metal‐Catalyzed Functionalization of Nonallylic Alkenyl Alcohols via Chain‐Walking Strategies

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
This minireview outlines recent advances in chain‐walking reactions of nonallylic alkenyl alcohols catalyzed by various transition metals, including palladium, ruthenium, rhodium, iridium, and nickel. Furthermore, the corresponding reaction mechanisms are discussed.
Yong Huang, Chong Liu, Jasmine X. Yan, Md Sajib Joardar, Ke Yang, Haibo Ge   +5 more
wiley   +1 more source

Organocatalytic Enantio- and Diastereoselective Synthesis of Dispirooxindole Derivatives with Adjacent Spirocyclic Centers via [4 + 2] Cycloadditions. [PDF]

J Org Chem
Hidalgo-León R, Trujillo-Sierra J, Sansano JM, Retamosa MG.   +3 more
europepmc   +1 more source

Asymmetric Transformations of α,β‐Unsaturated Oxazolidinones Catalyzed by C2‐Symmetric Chiral Iron Triad Complexes

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
This review highlights the evolution of highly enantioselective oxazolidinone transformations enabled by C2‐symmetric ligands, with emphasis on chiral iron triad complexes as cost‐effective, environmentally benign alternatives to late‐transition‐metal catalysts.
Arthur David, Thierry Ollevier
wiley   +1 more source

Bifunctional Monothiosquaramide-Catalyzed Enantioselective Addition of Masked Acyl Cyanide to Isatins: Umpolung Strategy for the Total Synthesis of (<i>S</i>)-(-)-Dioxibrassinin and (<i>R</i>)-(+)-Spirobrassinin. [PDF]

Org Lett
Reis FAA, Sathish M, Silva BV, Marra RKF, Magalhães LO, Rawal VH, Nachtigall FM, Santos LS.   +7 more
europepmc   +1 more source

Strategic Functionalization of Benzylic C(sp3)H Bonds: Unlocking the Potential for Enantioselective δ‐Lactonization

Advanced Synthesis &Catalysis, Volume 368, Issue 9, 5 May 2026.
Recent advancements in bio‐inspired Mn‐catalyzed directed oxidations of carboxylic acids have provided promising pathways for the synthesis of a wide variety of chiral γ‐lactones. In our current study, however, we have established a catalytic route using 0.25 mol% of electron‐rich Mn‐catalyst Mn(dMMbpbp) that redirects the lactonization reaction to the
Angshuk Saha, Arnau Call, Daniel L. J. Broere, Robertus J. M. Klein Gebbink   +3 more
wiley   +1 more source

Enantioselective C(sp³)-H bond functionalization enabled by Cp ^<i>x</i> M(iii) catalysis (M = Co, Rh, Ir). [PDF]

Chem Sci
Mou SB, Luo MP, Fang F, Cao S, Wu D, Wang SG.   +5 more
europepmc   +1 more source