Results 141 to 150 of about 3,272,143 (363)
Green Synthesis and Catalysis, 2021 Chiral α-amino-β2,2-amino acid is an ubiquitous fragment that presents in natural products, pharmaceuticals, and bioactive molecules. However, the catalytic enantioselective synthesis of α-amino-β2,2-amino acids with structural complexity and diversity ...
Xue Tian +4 more
doaj
Asian Journal of Organic Chemistry, EarlyView.An interrupted Barton–Zard reaction/Friedel–Crafts alkylation telescoped reaction provides aryl‐substituted pyrrolo[3,4‐b] cores in moderate‐to‐good yields as mostly single diastereomers. The reaction is tolerant of a wide range of electron‐deficient indoles and (hetero)aromatic nucleophiles, offering a modular approach for the synthesis of multi ...
Josip Rešetar +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.The highly selective acylative (dynamic) kinetic resolution of racemic paracyclophanols catalysed by a chiral isothiourea (5 mol%) is described (up to s = 50 at 49% conversion or up to 98:2 er and 96% yield in 30 examples). Rotational barriers were analysed for paracyclophanols and selected ester products.
Zhanyu Zhou +4 more
wiley +2 more sources
Enantioselective Synthesis of Allenes by Catalytic Traceless Petasis Reactions.
Journal of the American Chemical Society, 2017 Allenes are useful functional groups in synthesis as a result of their inherent chemical properties and established reactivity patterns. One property of chemical bonding renders 1,3-substituted allenes chiral, making them attractive targets for ...
Yao-Chen Jiang +3 more
semanticscholar +1 more source
Enantiopure Chiral Crystals: A Powerful Tool for Absolute Asymmetric Synthesis
Asian Journal of Organic Chemistry, EarlyView.This review covers absolute asymmetric syntheses, which allow the preparation of enantiomerically enriched chiral compounds from achiral precursors. By exploiting the crystallization of certain compounds as a conglomerate, enantiopure chiral crystals are spontaneously obtained.
Jiacheng Li, Valérie Alezra
wiley +1 more source
A FACILE SYNTHESIS OF (S) – (-) – PROPRANOLOL [PDF]
Journal of Sciences, Islamic Republic of Iran, 2003 A one-pot synthesis of (S)-(-)-propranolol is reported. Zn(NO3)2/(+)-tartaric acid catalyzed enantioselective synthesis of (S)-(-)-propranolol via kinetic resolution of key intermediate ?-naphthyl glycidyl ether with high optical and chemical yield.
doaj
Angewandte Chemie, 2017 The catalytic enantioselective synthesis of isoindolinones was achieved through the condensation of 2-acyl-benzaldehydes and anilines. In the presence of 1 mol % of a chiral phosphoric acid catalyst, reactions reach completion within 10 min and provide ...
C. Min, Ying-Rui Lin, D. Seidel
semanticscholar +1 more source
Asian Journal of Organic Chemistry, EarlyView.A straightforward method for constructing a tetrasubstituted carbon center through the in situ formation of 3‐methyleneisoindolinones as reactive intermediates has been developed. This process involves an acid‐catalyzed Meyer‐Schuster rearrangement of isoindolinone‐based propargylic alcohols, followed by an intermolecular Friedel‐Crafts alkylation ...
Arben Beriša +4 more
wiley +1 more source
Engineered C–N Lyases for Stereoselective Synthesis of Tertiary Amines
Angewandte Chemie, EarlyView.EDDS lyase was subjected to iterative cycles of site‐saturation mutagenesis and screened for increased activity for the addition of 2‐((methylamino)methyl)aniline to fumarate. The final mutant, EDDS lyase CEA, accepts various N‐methyl‐1‐phenylmethanamines derivatives, yielding N,N‐disubstituted L‐aspartic acids, as well as several ortho‐substituted ...
Laura Bothof +4 more
wiley +2 more sources
Journal of the American Chemical Society, 2017 The enantioselective intermolecular gold(I)-catalyzed [2+2] cycloaddition of terminal alkynes and alkenes has been achieved using non-C2-chiral Josiphos digold(I) complexes as catalysts, by the formation of the monocationic complex. This new approach has
Cristina García‐Morales +6 more
semanticscholar +1 more source