Results 141 to 150 of about 83,738 (273)

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

open access: yesAngewandte Chemie International Edition, EarlyView.
Marine polyhydroxylated macrolides’ drug discovery potential is limited by structural complexity and scarce material supply, hindering structure assignment, synthesis, and biological studies. Here, we present an integrated workflow that combines chemogenomic profiling, ultra‐high‐resolution NMR‐guided structural revision and stereochemical assignment ...
Malcolm R. P. George   +9 more
wiley   +1 more source

Enantioselective Oxidative Spirocyclization of Biaryl Hydroxy Carboxylic Acids: Enantioselective Synthesis of (–)‐Arnottin II

open access: yesChemistry – An Asian Journal, EarlyView.
The first catalytic and metal‐free enantioselective synthesis of (–)‐arnottin II is reported. A one‐pot hydrolysis/oxidative spirolactonization sequence, catalyzed by a chiral hypervalent iodine(I/III) complex under phosphate‐buffered conditions, establishes efficient control of the unstable biaryl hydroxy carboxylic acid (BHCA) intermediate, to afford
Kirara Saeda   +2 more
wiley   +1 more source

Enantioselective Synthesis of (+)-Coerulescine by a Phase-Transfer Catalytic Allylation of Diphenylmethyl tert-Butyl α-(2-Nitrophenyl)Malonate

open access: gold, 2020
Sangki Lee   +7 more
openalex   +1 more source

Selective N‐Alkylation of Unprotected Amino Sugars by Alcohols. Application to the Synthesis of Sugar‐Based Surfactants

open access: yesChemistryEurope, EarlyView.
A borrowing hydrogen strategy using an NHC‐Ir(III) catalyst enables selective N‐functionalization of unprotected amino sugars using alcohols as alkylating agents. The use of unprotected substrates avoids extra steps of protection/deprotection, minimizing waste generation.
Aitor Bermejo‐López   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy