Results 211 to 220 of about 14,649 (249)

Enantioselective Synthesis of (+)-Peganumine A

Journal of the American Chemical Society, 2016
A gram-scale enantioselective total synthesis of (+)-peganumine A was accomplished in 7 steps from commercially available 6-methoxytryptamine. Key steps included (a) a Liebeskind-Srogl cross-coupling; (b) a one-pot construction of the tetracyclic skeleton from an ω-isocyano-γ-oxo-aldehyde via a sequence of an unprecedented C-C bond forming ...
Piemontesi, Cyril, Wang, Qian, Zhu, Jieping   +2 more
openaire   +4 more sources

Enantioselective synthesis of levomilnacipran

Chemical Communications, 2012
A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.
Julien, Alliot, Edmond, Gravel, Florence, Pillon, David-Alexandre, Buisson, Marc, Nicolas, Eric, Doris   +5 more
openaire   +2 more sources

Enantioselective Synthesis of Phenylpropanetriols

Synthetic Communications, 1998
Abstract The four stereomer 1-(4-hydroxy-3-methoxy)-phenyl-1,2,3-propanetriols were obtained in about 30% yields starting from ferulic acid by a synthesis based on osmium catalyzed asymmetric dihydroxylation.
DELLA GRECA M, FIORENTINO, Antonio, MONACO, Pietro, PREVITERA L.   +3 more
openaire   +3 more sources

Enantioselective Synthesis of Arglabin

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Srinivas, Kalidindi, Won Boo, Jeong, Andreas, Schall, Rakeshwar, Bandichhor, Bernd, Nosse, Oliver, Reiser   +5 more
openaire   +2 more sources

Enantioselective synthesis of aminobenzazepinones

Tetrahedron Letters, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
C. V. C. Prasad, Stepen E. Mercer, Gene M. Dubowchik, John E. Macor   +3 more
openaire   +1 more source

Enantioselective Synthesis of Xanthatin

Chemistry – A European Journal, 2014
Abstract The enantioselective synthesis of cytostatic and antibiotic xanthatin ( 1 a ) is reported. As a key intermediate, a bicyclic compound 2 was identified, which can be readily synthesized from methyl‐2‐furoic acid in diastereo ...
Andreas, Bergmann, Oliver, Reiser
openaire   +2 more sources

Enantioselective Synthesis of Silanol

Journal of the American Chemical Society, 2008
An enantioselective nucleophilic substitution reaction of achiral dialkoxysilane has been developed. The reaction proceeds with efficient stereocontrol on the silicon chirality center to give the enantioenriched silyl ether, which can be converted to the silanol without loss of enantiopurity.
Kazunobu, Igawa, Junko, Takada, Tomohiro, Shimono, Katsuhiko, Tomooka   +3 more
openaire   +2 more sources

Enantioselective Synthesis of Silacyclopentanes

Angewandte Chemie, 2016
AbstractA variety of functionalized silacyclopentanes were synthesized by highly enantioselective β‐eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the β‐elimination was elucidated by DFT calculations.
Kazunobu Igawa, Daisuke Yoshihiro, Yusuke Abe, Katsuhiko Tomooka   +3 more
openaire   +2 more sources

An Enantioselective Synthesis of Voriconazole

The Journal of Organic Chemistry, 2013
A new seven-step sequence to access voriconazole, a clinically used antifungal agent, was developed. The initial catalytic asymmetric cyanosilylation is the key to constructing the consecutive tetra- and trisubstituted stereogenic centers. The fluoropyrimidine unit frequently triggered unexpected side reactions, but careful amendment of the reaction ...
Keiji, Tamura, Makoto, Furutachi, Naoya, Kumagai, Masakatsu, Shibasaki   +3 more
openaire   +2 more sources

An Enantioselective Synthesis of Tarchonanthuslactone

The Journal of Organic Chemistry, 2002
An enantioselective synthesis of tarchonanthuslactone has been achieved in eight steps from ethyl sorbate. The asymmetry of the route was introduced via a Sharpless asymmetric dihydroxylation allowing access to either enantiomer. The synthesis utilizes a palladium-catalyzed reduction and a diastereoselective base-catalyzed acetal formation as the key ...
Sarah D, Garaas, Thomas J, Hunter, George A, O'Doherty   +2 more
openaire   +2 more sources