Results 191 to 200 of about 67,862 (282)
Total Synthesis of the Spirocyclic Bis‐Indole Alkaloid (−)‐Owerreine via a [4+2] Annulation
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.The total synthesis of the bis‐indole alkaloid (−)‐owerreine has been accomplished by a diastereoselective [4+2] annulation between an enamine and an α,β−unsaturated indolenine precursor to form the 3‐spirocyclic tetrahydropyridine linkage of the natural product. DFT calculations allow an understanding of the mechanism of the key annulation.
Elisa Coll +4 more
wiley +2 more sources
Highly enantioselective synthesis controlled by spin-exchange interaction. [PDF]
Sci AdvYan Y +4 more
europepmc +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.A NiH‐catalyzed α‐alkenylation via Markovnikov hydronickellation of alkynes enables convenient access to α‐chrial β‐methylene carbonyl frameworks that are prevalent in biorelevant molecules. High regio‐ and enantioselectivities have been achieved with excellent functional group tolerance and applicability toward complex structures. The β‐methylene unit
Hyeontaek Nam +3 more
wiley +2 more sources
Enantioselective synthesis of C-C and C-N axially chiral pyrazole-based heterobiaryls. [PDF]
Chem SciHe J, Yang Z, Lin L, Feng X.
europepmc +1 more source
Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.Recent theoretical efforts to elucidate the origin of enantioselectivity in transition metal‐catalyzed propargylic substitution reactions are highlighted in this review. ABSTRACT In recent years, asymmetric catalytic propargylic substitution reactions have undergone remarkable development, enabling the construction of chiral carbon centers adjacent to ...
Ken Sakata, Yoshiaki Nishibayashi
wiley +1 more source
Copper-catalyzed enantioselective synthesis of γ-butenolides via radical diversification of allenoic acid. [PDF]
Nat CommunHan B, Nie Z, Ye C, Bao H.
europepmc +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.Dynamic kinetic resolution of tert‐alcohols co‐catalyzed by lipase and V‐MPS4 is reported, enabled by compartmentalization using a polydimethylsiloxane thimble. Physical separation of V‐MPS4 from lipase and Na2CO3 was crucial for preserving its racemization activity.
Satoshi Horino +5 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada +5 more
wiley +2 more sources
Silyl Rearrangements in Gold‐Catalyzed Transformations
European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.The synergy between the exceptional ability of gold catalysts to activate unsaturated substrates and the inherent tendency of organosilicon reagents to undergo silyl‐group rearrangements has unlocked a range of novel transformations, enabling access to otherwise challenging molecular architectures.
Patricia García‐Martínez +1 more
wiley +1 more source