Results 181 to 190 of about 14,649 (249)

Enantioselective Synthesis of 2,3-Disubstituted Azetidines via Copper-Catalyzed Boryl Allylation of Azetines. [PDF]

J Am Chem Soc
Zhu M, Sun J.
europepmc   +1 more source

Diastereoselective Copper‐Catalyzed Defluorosilylation of Pentafluoroethyl Alkenes to Access Polyfluorinated Allylsilanes

Chinese Journal of Chemistry, Volume 44, Issue 15, Page 2587-2592, 1 August 2026.
Under copper(I) catalysis, pentafluoroethylated alkenes can undergo smooth defluorosilylation to generate novel polyfluorinated products. The reaction exhibits high levels of diastereoselectivities for obtaining multisubstituted allylsilanes with control of the double bond geometry.
Yuwei Zong, Yihan Tang, Gavin Chit Tsui
wiley   +1 more source

Mechanochemistry as an Emerging Tool for Organofluorine Chemistry

Chemistry–Methods, Volume 6, Issue 8, August 2026.
Fluorinated scaffolds are central across many areas of chemistry, driving the demand for efficient and sustainable synthetic methods. Mechanochemistry has emerged as a powerful alternative to conventional approaches, offering reduced environmental impact, shorter reaction times, and unique reactivity and selectivity.
Marie Caldiero, Nicolas Delcroix, Vitalii Solomin, Thomas Castanheiro   +3 more
wiley   +1 more source

Counterion Effects on the Properties and Reactivity of Charged Photoredox Catalysts

ChemPhotoChem, Volume 10, Issue 8, August 2026.
The choice of a counterion for a charged photocatalyst has long been overlooked. In this review, we summarize recent reports on counterion effects in photocatalysis, providing readers with a comprehensive theoretical understanding and synthetic applications for the use of a carefully chosen counterion. Electrostatic interactions represent the strongest
Elina K. Taskinen, Burkhard König
wiley   +1 more source

A Bifunctional Cyclopropeneimine with a Tunable Hydrogen-Bond Donating Group and Its Application in the Enantioselective Synthesis of α,β-Diamino Phosphonates. [PDF]

ACS Omega
Chittoory AK, Patra R, Karushuda A, Rajaram S.   +3 more
europepmc   +1 more source

Trifluoromethylation‐Induced Lactonization: A Novel Transformation of Unsaturated Carboxylic Acids

ChemistryOpen, Volume 15, Issue 8, August 2026.
Fluorinated drugs often contain trifluoromethyl groups. The increasing importance of such drugs has resulted in more and more attention toward new or improved trifluoromethylation reactions. This review discusses possible reaction mechanisms and existing methods for one such process, trifluoromethylation‐induced lactonization, a distant relative of the
Attila M. Remete
wiley   +1 more source

Redirecting a Native Ene‐Reductase Toward Desaturation With Reverse Enantioselectivity

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
A native ene‐reductase, XenA, was repurposed to catalyze the reverse‐enantioselective desaturation of cyclohexanones. The final variant was obtained through extensive protein engineering, combining PROSS‐guided computational design with mutagenesis and screening.
Qing‐Qing Zeng, Cristina Berga, Carla Calvó‐Tusell, Marc Garcia‐Borràs, Zhen Liu   +4 more
wiley   +2 more sources

Enantioselective Synthesis of α-Aryl Ketones by a Cobalt-Catalyzed Semipinacol Rearrangement. [PDF]

Angew Chem Int Ed Engl
Kalomenopoulos PG, Emayavaramban B, Johnston CP.   +2 more
europepmc   +1 more source

1‐Aryl‐6,7‐Dimethoxy‐3,4‐Dihydroisoquinoline‐2(1H)‐Sulfonamides as hCA XII Selective Inhibitors: Experimental and Theoretical Studies to Interrogate the Isoform Selectivity

ChemMedChem, Volume 21, Issue 14, 29 July 2026.
Experimental and theoretical studies have disclosed the more relevant structural requirements for effective inhibition and an impressing selectivity toward tumor‐expressed hCA XII isoform over hCA II. Human carbonic anhydrase XII (hCA XII) represents an important pharmacological target for different types of cancer.
Federico Ricci, Anna Di Fiore, Andrea Angeli, Laura De Luca, Francesca Mancuso, Davide Esposito, Giuseppina De Simone, Claudiu T. Supuran, Rosaria Gitto   +8 more
wiley   +1 more source

Enantioselective synthesis of chiral 2,3-cis-disubstituted piperidines and C1-substituted tetrahydroisoquinolines by asymmetric Cu-catalyzed cyclizative aminoboration. [PDF]

Nat Commun
Zhang D, Yang H, Zhou Q, Tang W.
europepmc   +1 more source