Results 171 to 180 of about 14,649 (249)

Chemoenzymatic Synthesis of Chiral Piperidines Using the Immobilized Transaminase ATA‐117 in Continuous Flow Reactors

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
A robust continuous flow chemoenzymatic process was developed for the stereoselective synthesis of cis‐(2R,6R)‐2,6‐disubstituted piperidines, including the natural alkaloid (–)‐pinidinone. The asymmetric transamination of α,β‐unsaturated ketones was catalyzed by immobilized ATA‐117, followed by spontaneous aza‐Michael cyclization, providing the desired
Sara Vicinanza, Ilaria Magrini Alunno, Stefania Patti, Morena Pirotta, Francesca Annunziata, Raffaella Gandolfi, Paola Conti, Chiara Borsari, Ivan Bassanini, Erica Elisa Ferrandi, Daniela Monti, Lucia Tamborini   +11 more
wiley   +1 more source

Enantioselective Synthesis of α-Arylated Allene Ketones Through Sequential Bismuth(V)-mediated Arylation and Organocatalytic Protonation. [PDF]

Angew Chem Int Ed Engl
Zhu K, Sun Y, Ma Y, Wu Z, Lu Y.
europepmc   +1 more source

Quantum Phenomena in Molecular and Biological Systems: A Decoherence‐Based Decision Framework With Falsifiable Predictions and a Failure‐Mode Taxonomy

Advanced Physics Research, Volume 5, Issue 8, August 2026.
A physics‐grounded framework based on decoherence timescales (τ_dec vs τ_func), Markovian validity, and falsifiability criteria is applied across molecular systems to distinguish where quantum effects are necessary, marginal, or irrelevant. The analysis integrates quantum chemistry, biological quantum mechanisms, and quantum computing under a unified ...
Sarfaraz K. Niazi
wiley   +1 more source

Enantioselective synthesis of calix[4]arenes with C-C axial and inherent chirality <i>via</i> palladium/chiral norbornene cooperative catalysis. [PDF]

Chem Sci
You Y, Cheng H, Huang X, Wang P, Cong H, Cheng HG, Zhou Q.   +6 more
europepmc   +1 more source

Unlocking Stereodefined Olefins by Z‐Selective Transition Metals‐catalyzed C−H Activations

ChemCatChem, Volume 18, Issue 15, 14 August 2026.
The synthesis of Z‐olefins is an important challenge in synthetic organic chemistry. Within this review, we report a comprehensive overview of transition metals‐catalyzed Z‐selective C–H activations of (hetero)arenes for the synthesis of stereodefined olefins.
Francesco Capranica, Silvia Cattani, Gianpiero Cera   +2 more
wiley   +1 more source

Structure‐Guided Engineering of a Ser192Ala Variant Enhances Bidirectional Catalysis in Amycolatopsis sulphurea L‐Alanine Dehydrogenase

ChemCatChem, Volume 18, Issue 15, 14 August 2026.
A rationally engineered Ser192Ala variant of Amycolatopsis sulphurea L‐alanine dehydrogenase (L‐AlaDH) exhibits ∼2‐fold higher catalytic efficiency in both reductive amination and oxidative deamination. Experimental characterization confirms maintained stability under tested conditions, highlighting its potential as an improved biocatalyst for ...
Tuba Okur Aksu, Fatih Aktaş, Onur Serçinoğlu, Barış Binay   +3 more
wiley   +1 more source

Enantioselective Synthesis of Spirocyclic Nitrogen-Containing Heterocycles Catalyzed by an Iridium-Containing Cytochrome. [PDF]

J Am Chem Soc
Xu J, Bloomer BJ, Brunn JN, Quest AP, Chakraborty S, Schneider JE, Clark DS, Hartwig JF.   +7 more
europepmc   +1 more source

A Comparative Study of the Influence of Water and Temperature on the Racemization of Five‐ and Six‐Membered l‐Alanine‐Derived Imides

Chirality, Volume 38, Issue 8, August 2026.
Racemization of chiral imides in dimethylformamide is shown to increase with increasing water content and temperature. The six‐membered imide ring system is more stable than the five‐membered analogue, with slower racemization under identical conditions and an absence of competing side reactions.
Diksha U. Sawant, William Chant, Peter Halat, Ekaterina I. Izgorodina, David R. Turner   +4 more
wiley   +1 more source

Enantioselective Synthesis of α-Oxygenated Ketones via Organocatalytic Formal O-H Bond Insertion of Sulfonium Ylides. [PDF]

J Am Chem Soc
Qian C, Zhong Z, Xu Q, Li P, Zhang C, Sun J.   +5 more
europepmc   +1 more source

Mass Spectrometry in Chiral Analysis and Synthesis

Chirality, Volume 38, Issue 8, August 2026.
Chiral molecules have the same mass, yet there are MS approaches that can distinguish chiral molecules. MS‐based chiral chemistry matters in fundamental physical experiments, industrial applications, and clinical analysis. ABSTRACT Mass spectrometry (MS) has a role to play in chiral chemistry, in part through methods based on microdroplets and non ...
Brison A. Shira, Mahdiyeh Shahi, R. Graham Cooks   +2 more
wiley   +1 more source