Catalytic asymmetric synthesis of the alkaloid (+)-myrtine [PDF]
, 2008 A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient
Adriaan J. Minnaard +62 more
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Enantioselective Total Synthesis of Aplyviolene [PDF]
Journal of the American Chemical Society, 2011 The enantioselective total synthesis of the rearranged spongian diterpene aplyviolene has been completed in 14 steps from the known hydroazulenone 8. The key junction of the hydrocarbon and oxygenated fragments to form the critical C8 quaternary carbon stereocenter and set the stage for elaborating the delicate bicyclic lactone functionality was ...
Martin J, Schnermann, Larry E, Overman
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Enantioselective Synthesis of Biscyclopropanes Using Alkynes as Dicarbene Equivalents [PDF]
, 2023 Chuntao Wang +3 more
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Enantioselective Synthesis of Endohedral Metallofullerenes
Journal of the American Chemical Society, 2011 Endohedral metallofullerenes are promising materials in biomedical and material sciences. In particular, they are of interest as agents for magnetic resonance imaging (MRI), photovoltaic devices, and semimetallic components. The synthesis of chiral endofullerenes represents one step further in the potential use of these carbon allotropes; however, this
Sawai K. +10 more
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Forging Fluorine-Containing Quaternary Stereocenters by a Light-Driven Organocatalytic Aldol Desymmetrization Process [PDF]
, 2017 Reported herein is a light-triggered organocatalytic strategy for the desymmetrization of achiral 2-fluoro-substi- tuted cyclopentane-1,3-diketones.
Ametamey +49 more
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Synthetic Studies Directed Toward Streptenol D: Enantioselective Preparation of the 3,5-diacetoxy-6\u3cem\u3eE\u3c/em\u3e,8\u3cem\u3eE\u3c/em\u3e-decadiene Segment [PDF]
, 1998 The enantioselective preparation of 2-(3′R,5′R-diacetoxy-6E,8E-decadienyl)-1,3-dioxane, (+)-13, is described. This synthesis of the skeleton of streptenol D utilizes the ability of a diene-complexed (tricarbonyl)iron unit to serve as a protecting and ...
Dasgupta, Bireshwar, Donaldson, William
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]
, 2016 The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D. +2 more
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, 2012 We analyze limited enantioselective (LES) autocatalysis in a temperature gradient and with internal flow/recycling of hot and cold material. Microreversibility forbids broken mirror symmetry for LES in the presence of a temperature gradient alone.
Blanco, Celia +5 more
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A unique method for highly enantioselective synthesis of N–C axially chiral compounds [PDF]
, 2021 Osamu Kitagawa
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Enantioselective Total Synthesis of (+)-Amabiline [PDF]
Organic Letters, 2012 The first total synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile, is reported. This convergent, enantioselective synthesis proceeds in 15 steps (10-step longest linear sequence) in 6.2% overall yield and features novel methodology to construct the unsaturated pyrrolizidine or (-)-supinidine core.
Timothy J, Senter +2 more
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