Results 61 to 70 of about 14,649 (249)

Pd‐Catalyzed Asymmetric Dearomative Heck/Tsuji‐Trost Difunctionalization of Naphthalenes

Advanced Science, EarlyView.
We have developed a palladium‐catalyzed asymmetric dearomative Heck/Tsuji‐Trost 1,4‐difunctionalization reaction of naphthalenes, affording 4‐aminospirocyclohexene oxindole products bearing two remote chiral centers. Through the effect of the newly designed chiral sulfinamide phosphine ligand with large steric hindrance, side reactions are inhibited ...
Long‐Ling Ma, Bing Xu, Junliang Zhang, Zhan‐Ming Zhang   +3 more
wiley   +1 more source

Emergence of Chiral Defective Pores Through Chiral Linker Exchange in Nonchiral MOFs for Enantioselective Recognition

Angewandte Chemie, EarlyView.
Chiral recognition remains challenging due to minimal property differences. This work develops chiral defective MOFs via linker exchange to enable rapid, direct, luminescent enantioselective sensing, offering a simple, modular strategy that broadens MOF functionality for portable, low‐cost applications in pharmaceuticals, food safety, and environmental
Zongsu Han, Kun‐Yu Wang, Jiatong Huo, Joshua Rushlow, Zhaoyi Liu, Yihao Yang, Rong‐Ran Liang, Wei Shi, Hong‐Cai Zhou   +8 more
wiley   +2 more sources

Recent advances in catalytic asymmetric synthesis

Frontiers in Chemistry
Asymmetric catalysis stands at the forefront of modern chemistry, serving as a cornerstone for the efficient creation of enantiopure chiral molecules characterized by their high selectivity. In this review, we delve into the realm of asymmetric catalytic
Ashna Garg, Dominick Rendina, Hersh Bendale, Takahiko Akiyama, Iwao Ojima, Iwao Ojima   +5 more
doaj   +1 more source

Enantioselective Total Synthesis of (−)‐Deoxoapodine [PDF]

Angewandte Chemie International Edition, 2017
AbstractThe first enantioselective total synthesis of (−)‐deoxoapodine is described. Our synthesis of this hexacyclic aspidosperma alkaloid includes an efficient molybdenum‐catalyzed enantioselective ring‐closing metathesis reaction for the desymmetrization of an advanced intermediate that introduces the C5‐quaternary stereocenter.
Taek Kang, Kolby L. White, Tyler J. Mann, Amir H. Hoveyda, Mohammad Movassaghi   +4 more
openaire   +3 more sources

Reimagining Lignin Valorization: Synthetic Biology–Enabled Sustainable Aromatic Carbon Biomanufacturing

Advanced Science, EarlyView.
The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li, Jun‐Jie Zhangyang, Bing‐Zhi Li, Zhi‐Hua Liu, Ying‐Jin Yuan   +4 more
wiley   +1 more source

Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Nature Communications, 2017
Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective ...
Naoki Yoneda, Yuki Fujii, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara   +4 more
doaj   +1 more source

Rational Design of π‐Conjugated Polymers for Enantioselective Recognition of Amino Acids

Advanced Electronic Materials, EarlyView.
A family of conducting polymers is proposed for the enantioselective recognition of amino acids. The films are generated by electropolymerization of thiophene trimers containing chiral features, with the advantage that the polymerization can be induced at much lower overpotentials compared to classic thiophene monomers, thus avoiding parasitic ...
Gerardo Salinas, Rana Nakar, Getnet Kassahun, Matthieu Raoux, Jochen Lang, Damien Thuau, Mamatimin Abbas, Eric Cloutet, Alexander Kuhn   +8 more
wiley   +1 more source

Enantioselective Synthesis of (+)- and (−)-Dihydroepiepoformin and (+)-Epiepoformin

Organic Letters, 2005
[reaction: see text] The enantioselective synthesis of both enantiomers of dihydroepiepoformin (1) and (+)-epiepoformin (2) was achieved from (p-tolylsulfinyl)methyl-p-quinols (SR)- or (SS)-3 and (4R,SR)-4, respectively. Key features include the stereocontrolled conjugate addition of AlMe3 to p-quinol 3 and retrocondensation to the ketone functionality,
Carreño, M. Carmen, Merino, Estíbaliz, Ribagorda, Maria, Somoza, Álvaro, Urbano, Antonio   +4 more
openaire   +3 more sources

Enantioselective Total Synthesis of (−)‐Diversonol

Chemistry – A European Journal, 2013
AbstractFor the synthesis of (−)‐diversonol (ent‐1), an enantioselective domino‐Wacker/carbonylation/methoxylation reaction and an enantioselective Wacker oxidation were used to give the chroman in high yield and 96 % and 93 % ee, respectively. Dihydroxylation at the vinyl moiety using the Sharpless procedure and a Wittig–Horner reaction followed by ...
Tietze, Lutz Friedjan, Jackenkroll, Stefan, Raith, Christian, Spiegl, Dirk A., Reiner, Johannes R., Campos, Maria Claudia Ochoa   +5 more
openaire   +3 more sources

Enantioselective Total Synthesis of (−)-Dactylolide

Organic Letters, 2006
[reaction: see text] The enantioselective total synthesis of (-)-dactylolide is reported. The absolute stereochemistry of the tetrahydropyran was established by catalytic asymmetric Jacobsen hetero-Diels-Alder reaction. The remote C19 stereocenter was introduced by a sequence of chelation-controlled Grignard addition and Ireland-Claisen rearrangement.
Louis, Ignace, L. Hungerford, Natasha, J. Humphries, Edward, D. McLeod, Malcolm   +3 more
openaire   +5 more sources