Results 41 to 50 of about 14,649 (249)

Enantioselective desymmetrization strategy of prochiral 1,3-diols in natural product synthesis

Beilstein Journal of Organic Chemistry
Enantioselective desymmetrization is employed as a powerful tool for the creation of chiral centers. Within this scope, the enantioselective desymmetrization of prochiral 1,3-diols, which generates chiral centers by enantioselective functionalization of ...
Lihua Wei, Rui Yang, Zhifeng Shi, Zhiqiang Ma   +3 more
doaj   +1 more source

Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

Nature Communications, 2021
Chiral acetylenic derivatives are found in many bioactive compounds and are versatile building blocks in organic synthesis. Here, the authors report a mild enantioselective nickel/Lewis acid-catalyzed asymmetric propargylic substitution reaction which is
Xihao Chang, Jiayin Zhang, Lingzi Peng, Chang Guo   +3 more
doaj   +1 more source

Enantioselective formal carbene insertion into C–N bond of aminal as a concise track to chiral α-amino-β2,2-amino acids and synthetic applications

Green Synthesis and Catalysis, 2021
Chiral α-amino-β2,2-amino acid is an ubiquitous fragment that presents in natural products, pharmaceuticals, and bioactive molecules. However, the catalytic enantioselective synthesis of α-amino-β2,2-amino acids with structural complexity and diversity ...
Xue Tian, Xinfang Xu, Tongfei Jing, Zhenghui Kang, Wenhao Hu   +4 more
doaj   +1 more source

Light‐Imprinted Chirality in Nanomaterials: From Principles to Applications

Advanced Science, EarlyView.
Light‐induced chirality represents a transformative paradigm for fabricating chiral nanostructures. This review provides a comprehensive framework encompassing light‐based strategies for imprinting and tuning chirality in nanomaterials, which guides researchers in harnessing light to create next‐generation functional materials.
Xinru Jin, Emiliano Cortés, Alexander O. Govorov, Tao Ding   +3 more
wiley   +1 more source

Water, Alcohols, Amines, and Amides as Formal Hydrogen‐Atom‐Transfer Reagents Through Activation With Redox‐Active Lewis Acids

Angewandte Chemie, EarlyView.
Protic molecules containing strong O─H or N─H bonds typically resist hydrogen‐atom abstraction because of the high reactivity of the resulting heteroatom‐centered radicals. However, association of the protic molecules with redox‐active Lewis acids can provide powerful hydrogen‐atom donors or proton‐coupled‐electron‐transfer reagents.
Petra Vojáčková, Armido Studer
wiley   +2 more sources

Catalytic synthesis of chiral sulfinimidate esters via oxidative esterification of sulfenamides

Nature Communications
Aza-sulfur compounds, such as sulfilimines, sulfoximines, etc, are increasingly recognized as essential contributors to advancements in drug development and asymmetric synthesis.
Hua-Jie Jiang, Xue-Qin Tu, Xin-Yi Kong, Ju-Yan Wang, Yu-Yang Liu, Meng-Lan Shen, Chuan-Zhi Yao, Qiankun Li, Jie Yu   +8 more
doaj   +1 more source

Atroposelective Access to π‐Conjugated 1,2‐Azaborepines Enabled by Palladium‐Catalyzed Cyclization of N‐Heterobiaryls with Alkynylboronates

Advanced Science, EarlyView.
We report a palladium‐catalyzed atroposelective cyclization of N‐heterobiaryl triflates with alkynyl boronates to access seven‐membered 1,2‐BN‐bridged biaryls with high yields and excellent enantioselectivity via a cascade DyKAT, cis‐carbopalladation, and 1,2‐migration, which expands the toolbox for axially chiral π‐conjugated boron compounds and opens
Fengya He, Zhen Wang, Haoyu Guo, Shuguang Chen, Xu Zhang, Yongjia Shang, Hui Wang   +6 more
wiley   +1 more source

Underexplored Catalysts as General Structures: Application of Machine Learning Techniques for Reaction‐Specific Datasets

Angewandte Chemie, EarlyView.
Bias‐aware machine learning identified an underexplored imidazolidinone catalyst with broad competitive performance in iminium‐based reactions. Experimental benchmarking shows how data‐driven prioritization can uncover overlooked catalyst scaffolds from sparse and historically biased literature data.
Jiajing Li, Isaiah O. Betinol, Junshan Lai, Soresu Juyo, Jolene P. Reid   +4 more
wiley   +2 more sources

Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides

Beilstein Journal of Organic Chemistry, 2017
Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination.
Ryota Miyaji, Yuuki Wada, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara   +4 more
doaj   +1 more source

Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J

Nature Communications, 2020
Despite being known for more than 50 years, yuzurimine-type alkaloids have not been accessed by total synthesis. Here, the authors report the first enantioselective total synthesis of (+)-Caldaphnidine J, a highly complex yuzurimine-type Daphniphyllum ...
Lian-Dong Guo, Yan Zhang, Jingping Hu, Chengqing Ning, Heyifei Fu, Yuye Chen, Jing Xu   +6 more
doaj   +1 more source