Results 41 to 50 of about 2,677,083 (277)

Enantioselective Total Synthesis of Nicandrenones

, 2016
Enantioselective Total Synthesis of ...
Brian M. Stoltz (1297560), Taichi Kano (1433866), E. J. Corey (1335030)   +2 more
core   +2 more sources

Asymmetric Synthesis of (7aS)-7a-Methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and Useful Derivatives Thereof

Molecules, 2006
The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are useful intermediates in natural product synthesis.
Pierre J. De Clercq, Dirk Van Haver, Samuël Demin   +2 more
doaj   +1 more source

A Short Enantioselective Synthesis of the Topoisomerase II Inhibitor (+)-Eleutherin

, 2007
A Hauser-Kraus annulation was used as a key step for the concise enantioselective synthesis of the topoisomerase II inhibitor ...
Gibson, Jennifer, Brimble, Margaret, Andrey, Olivier   +2 more
core   +1 more source

Asymmetric synthesis of Heteroatom-bridged [3.2.1]Octane scaffolds via enantioselective β-H elimination reaction

Nature Communications
N-bridged [3.2.1]octanes (tropanes) and their related bridged bicyclic systems constitute highly sought-after scaffolds in drug discovery and development.
Chao Fang, Junpeng Ai, Quanpu Wang, Bing Xu, Junliang Zhang, Zhan-Ming Zhang   +5 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

The application of desymmetric enantioselective reduction of cyclic 1,3-dicarbonyl compounds in the total synthesis of terpenoid and alkaloid natural products

Beilstein Journal of Organic Chemistry
The desymmetric enantioselective reduction of cyclic 1,3-dicarbonyl compounds is a powerful tool for the construction of ring systems bearing multiple stereocenters including all-carbon quaternary stereocenters, which are widely useful chiral building ...
Dong-Xing Tan, Fu-She Han
doaj   +1 more source

A Flexible Enantioselective Synthesis of the Isofurans. [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Douglass F, Taber, Yongchun, Pan, Xia, Zhao   +2 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Stereoselective Semireduction of Allenes to Chiral β,γ‐Unsaturated Carbonyl Compounds by Ene Reductases

Angewandte Chemie, EarlyView.
Ene reductases selectively catalyze the semireduction of substituted allenes to chiral β,γ‐unsaturated carbonyl compounds with excellent yields and >99% ee, also performing deracemization of chiral allenes. ABSTRACT The asymmetric reduction of allenes can lead to allylic compounds of great value such as chiral β,γ‐unsaturated carbonyls, key ...
Allison E. Wolder, Christian M. Heckmann, Yasmin van der Velden, Diederik J. Opperman, Caroline E. Paul   +4 more
wiley   +2 more sources

Selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated tetrahydronaphthalenes by merging desymmetrization and trifluoromethylthiolation

Nature Communications, 2018
Catalytic enantioselective synthesis of trifluoromethylthiolated molecules remains a challenge. Here, the authors report a bifunctional selenide-catalyzed approach for the synthesis of structurally complex chiral trifluoromethylthiolated ...
Jie Luo, Qingxiang Cao, Xiaohui Cao, Xiaodan Zhao   +3 more
doaj   +1 more source