Results 71 to 80 of about 67,862 (282)
Catalytic synthesis of chiral sulfinimidate esters via oxidative esterification of sulfenamides
Nature CommunicationsAza-sulfur compounds, such as sulfilimines, sulfoximines, etc, are increasingly recognized as essential contributors to advancements in drug development and asymmetric synthesis.
Hua-Jie Jiang +8 more
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Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides
Beilstein Journal of Organic Chemistry, 2017 Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination.
Ryota Miyaji +4 more
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Organocatalytic synthesis of axially chiral atropisomers [PDF]
, 2017 This review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described.
Renzi, P.
core +1 more source
Enantioselective Total Synthesis of (−)‐Diversonol
Chemistry – A European Journal, 2013 AbstractFor the synthesis of (−)‐diversonol (ent‐1), an enantioselective domino‐Wacker/carbonylation/methoxylation reaction and an enantioselective Wacker oxidation were used to give the chroman in high yield and 96 % and 93 % ee, respectively. Dihydroxylation at the vinyl moiety using the Sharpless procedure and a Wittig–Horner reaction followed by ...
Tietze, Lutz Friedjan +5 more
openaire +3 more sources
Enantioselective Total Synthesis of (+)‐Eucophylline
Chemistry – A European Journal, 2022 AbstractThe total enantioselective synthesis of (+)‐eucophylline 1 was achieved using as a key‐structural motif a chiral piperidinone bearing the natural product all‐carbon quaternary stereocenter. The elaboration of the latter is based on two strategies relying on the free‐radical carbo‐cyanation and sulfonyl‐cyanation respectively of enantiopure ...
Iman Traboulsi +4 more
openaire +2 more sources
Palladium-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to Five-, Six-, and Seven-Membered β-Substituted Cyclic Enones: Enantioselective Construction of All-Carbon Quaternary Stereocenters [PDF]
, 2011 The first enantioselective Pd-catalyzed construction of all-carbon quaternary stereocenters via 1,4-addition of arylboronic acids to β-substituted cyclic enones is reported. Reaction of a wide range of arylboronic acids and cyclic enones using a catalyst
Gatti, Michele +3 more
core +2 more sources
Photoenzymatic catalysis enables enantioselective radical dearomative spirocyclization
Nature CommunicationsDearomatization offers a powerful route towards three-dimensional spirocyclic architectures, which are pivotal in bioactive molecules and pharmaceuticals, particularly for enantioselective construction of congested quaternary spirocenters.
Changtong Zhu +9 more
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Nature Communications, 2017 Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective ...
Naoki Yoneda +4 more
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Recent advances in catalytic asymmetric synthesis
Frontiers in ChemistryAsymmetric catalysis stands at the forefront of modern chemistry, serving as a cornerstone for the efficient creation of enantiopure chiral molecules characterized by their high selectivity. In this review, we delve into the realm of asymmetric catalytic
Ashna Garg +5 more
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Green Synthesis and Catalysis, 2021 Chiral α-amino-β2,2-amino acid is an ubiquitous fragment that presents in natural products, pharmaceuticals, and bioactive molecules. However, the catalytic enantioselective synthesis of α-amino-β2,2-amino acids with structural complexity and diversity ...
Xue Tian +4 more
doaj +1 more source