Results 71 to 80 of about 2,677,083 (277)
Angewandte Chemie, EarlyView.Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang +1 more
wiley +2 more sources
Photoenzymatic catalysis enables enantioselective radical dearomative spirocyclization
Nature CommunicationsDearomatization offers a powerful route towards three-dimensional spirocyclic architectures, which are pivotal in bioactive molecules and pharmaceuticals, particularly for enantioselective construction of congested quaternary spirocenters.
Changtong Zhu +9 more
doaj +1 more source
Bifunctional organocatalysts for the asymmetric synthesis of axially chiral benzamides
Beilstein Journal of Organic Chemistry, 2017 Bifunctional organocatalysts bearing amino and urea functional groups in a chiral molecular skeleton were applied to the enantioselective synthesis of axially chiral benzamides via aromatic electrophilic bromination.
Ryota Miyaji +4 more
doaj +1 more source
Enantioselective Total Synthesis of Aspidophytine
, 2016 Enantioselective Total Synthesis of ...
Yunxin Bo (1585219) +3 more
core +1 more source
Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides
Advanced Science, EarlyView.Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan +4 more
wiley +1 more source
Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation
Angewandte Chemie, EarlyView.The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam +5 more
wiley +2 more sources
Asymmetric total synthesis of yuzurimine-type Daphniphyllum alkaloid (+)-caldaphnidine J
Nature Communications, 2020 Despite being known for more than 50 years, yuzurimine-type alkaloids have not been accessed by total synthesis. Here, the authors report the first enantioselective total synthesis of (+)-Caldaphnidine J, a highly complex yuzurimine-type Daphniphyllum ...
Lian-Dong Guo +6 more
doaj +1 more source
Enantioselective Total Synthesis of (+)‐Obtusenyne. [PDF]
ChemInform, 2003 A total synthesis of the laurencia metabolite (+)-obtusenyne has been completed. The key steps include a Sharpless kinetic resolution and an asymmetric glycolate alkylation to establish the stereogenic centers adjacent to the ether linkage and a ring-closing metathesis reaction to construct the nine-membered ether without the aid of a cyclic ...
Michael T, Crimmins, Mark T, Powell
openaire +2 more sources
Enantioselective Synthesis of (−)‐10‐Hydroxyacutuminine
Angewandte Chemie International Edition, 2022 AbstractAn enantioselective synthesis of (−)‐10‐hydroxyacutuminine is reported. Central to our strategy is a photochemical [2+2] cycloaddition that forges two of the quaternary stereocenters present in the acutumine alkaloids. A subsequent retro‐aldol/Dieckmann sequence furnishes the spirocyclic cyclopentenone.
Denise C. Grünenfelder +5 more
openaire +3 more sources
Enantioselective Total Synthesis of Hispidospermidin
, 2016 Enantioselective Total Synthesis of ...
Larry E. Overman (1264596) +1 more
core +1 more source