Results 111 to 120 of about 39,817 (294)

Enantioselective Synthesis of (−)-Basiliskamide A [PDF]

Organic Letters, 2012
Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available β-hydroxy ester 7.
William R. Roush, Ming Chen
openaire   +3 more sources

Biocatalytic Isocitrate Production from Low‐Concentration Gaseous CO2 and Biobased 2‐Oxogultarate

Advanced Energy and Sustainability Research, EarlyView.
Biocatalytic isocitrate production from 2‐oxoglutarate and low‐concentration CO2 below 5% in the presence of NADPH and manganese ion was developed. Isocitrate dehydrogenase (IDH) from yeast (EC 1.1.1.42) is an enzyme that catalyzes the decarboxylating isocitrate into 2‐oxogurtarate and carbon dioxide and the reverse process of the introducing carbon ...
Masamichi Hino, Yutaka Amao
wiley   +1 more source

Engineered Biocatalyst for Enantioselective Hydrazone Reduction

Angewandte Chemie, EarlyView.
Here, we report the discovery and engineering of a hydrazone reductase (HRED) biocatalyst that promotes efficient reduction of protected hydrazones with exceptional stereocontrol. These biotransformations offer a sustainable strategy for synthesizing valuable chiral N─N containing products that are commonly found in pharmaceuticals and agrochemicals ...
Amy E. Hutton, Fei Zhao, Elizabeth Ho, Jack Domenech, Vanessa Harawa, Murray J. B. Brown, Gideon Grogan, Phillip D. Clayman, Nicholas J. Turner, Anthony P. Green   +9 more
wiley   +2 more sources

Inter- and intramolecular enantioselective carbolithiation reactions

Beilstein Journal of Organic Chemistry, 2013
In this review we summarize recent developments in inter- and intramolecular enantioselective carbolithiation reactions carried out in the presence of a chiral ligand for lithium, such as (−)-sparteine, to promote facial selection on a C=C bond.
Asier Gómez-SanJuan, Nuria Sotomayor, Esther Lete   +2 more
doaj   +1 more source

Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin

Pharmaceuticals, 2017
Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group.
Carla Fernandes, Andreia Palmeira, Inês I. Ramos, Carlos Carneiro, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Salette Reis, Madalena M.M. Pinto   +10 more
doaj   +1 more source

Chiral recognition of neutral guests by chiral naphthotubes with a bis-thiourea endo-functionalized cavity

Nature Communications, 2023
Developing chiral receptors with an endo-functionalized cavity for chiral recognition is of great significance in the field of molecular recognition.
Song-Meng Wang, Yan-Fang Wang, Liping Huang, Li-Shuo Zheng, Hao Nian, Yu-Tao Zheng, Huan Yao, Wei Jiang, Xiaoping Wang, Liu-Pan Yang   +9 more
doaj   +1 more source

Chiral Amplification and Regulation: Design and Applications of Circularly Polarized Luminescence‐Active Materials Derived From Macrocyclic Compounds

Aggregate, EarlyView.
The graphical abstract highlights the key concepts of this review, including chiral transfer and amplification mechanisms, macrocyclic compounds, circularly polarized luminescence (CPL) applications, chiral sensing, asymmetric catalysis, and stimuli‐responsive applications.
Wei Zhang, Mao‐Qin Liu, Yang Luo
wiley   +1 more source

Molecular Characterization of a Novel Cold-Active Hormone-Sensitive Lipase (HaHSL) from Halocynthiibacter Arcticus

Biomolecules, 2019
Bacterial hormone-sensitive lipases (bHSLs), which are homologous to the catalytic domains of human HSLs, have received great interest due to their uses in the preparation of highly valuable biochemicals, such as drug intermediates or chiral building ...
Ly Thi Huong Luu Le, Wanki Yoo, Changwoo Lee, Ying Wang, Sangeun Jeon, Kyeong Kyu Kim, Jun Hyuck Lee, T. Doohun Kim   +7 more
doaj   +1 more source

Towards energetically viable asymmetric deprotonations : selectivity at more elevated temperatures with C2-symmetric magnesium bisamides [PDF]

, 2011
A novel chiral magnesium bisamide has enabled the development of effective asymmetric deprotonation protocols at substantially more elevated temperatures.
Aggarwal, Alexakis, Allan, Allan J. B. Watson, Anderson, Aoki, Aoki, Aoki, Aoki, Bassindale, Blümke, Brownbridge, Brownbridge, Bunn, Bunn, Bunn, Busch-Petersen, Carswell, Clegg, Conway, Corey, Cousins, Eaton, Eaton, Graf, Graf, Gronnow, Hama, Henderson, Henderson, Henderson, Henderson, Henderson, Hodgson, Ila, Kerr, Kerr, Kerr, Knochel, Leitner, Linsey S. Bennie, Melzig, Michael Middleditch, Mulvey, Navarro, Netherton, Sato, Shirai, Shirai, Simpkins, Simpkins, Westerhausen, William J. Kerr, Wunderlich, Çalimsiz   +54 more
core   +1 more source

Pathway Complexity in Supramolecular Polymerization of Porphyrin Dyads for Kinetic Control of Helicity

Aggregate, EarlyView.
Supramolecular polymerization of porphyrin dyads (PDs) forms kinetically stable nanoparticles (PDParticle) via rapid cooling and thermodynamically stable fibrous polymers (PDFiber) via slow cooling. PDParticle gradually transforms into PDFiber. Introducing chiral alkyl chains induces helicity, with (S)‐PD favoring M helices and (R)‐PD favoring P ...
Hosoowi Lee, Yongho Lee, Minhyeong Lee, Dae Eun Kang, Jiwon Kim, Dong Ha Kim, Woo‐Dong Jang   +6 more
wiley   +1 more source