Results 181 to 190 of about 175,320 (374)

Redirecting the Peptide Cleavage Causes Protease Inactivation

open access: yesAngewandte Chemie International Edition, EarlyView.
Cysteine proteases catalyze substrate cleavage by a two‐step acyl transfer mechanism. Newly designed peptidic inhibitors of human cathepsin B with N‐terminal carbamate warheads undergo a redirected cleavage and generate non‐canonical covalent complexes.
Christian Breuer   +20 more
wiley   +1 more source

Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling

open access: yesAngewandte Chemie International Edition, Accepted Article.
Inositol pyrophosphates (PP‐InsPs) are highly phosphorylated signaling molecules that regulate diverse cellular processes, including phosphate homeostasis and energy metabolism across species. Despite extensive research on well‐characterized exhaustively phosphorylated PP‐InsPs, such as 5‐PP‐InsP5 (5‐InsP7) and 1,5‐(PP)2‐InsP4 (1,5‐InsP8), the ...
Kevin Ritter   +6 more
wiley   +1 more source

Enantioselective hydrolysis of amino acid esters in organized hybrid assemblies.

open access: bronze, 1989
Ryuichi Ueoka   +4 more
openalex   +2 more sources

Half-Sandwich d6-Metal (CoIII, RhIII, IrIII, RuII)-Catalyzed Enantioselective C–H Activation

open access: yesSynOpen, 2023
Pu-Fan Qian   +4 more
doaj   +1 more source

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