Results 101 to 110 of about 49,920 (244)

Devic mouse: a spontaneous double-transgenic mouse model of human opticospinal multiple sclerosis and autoimmune T- B cell cooperation [PDF]

, 2007
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). Myelin antigen(s) specific T cells, B cells, and antibodies are thought to play a role in the pathogenesis of MS.
Krishnamoorthy, Gurumoorthy
core  

Targeting microglia-Th17 feed-forward loop to suppress autoimmune neuroinflammation

Journal of Neuroinflammation
Microglia and Th17 cells are the major immunopathogenic cells in multiple sclerosis and its animal model of immune aspects, experimental autoimmune encephalomyelitis (EAE).
Jun Xiao, Zihan Meng, Yao Lu, Zongchang Nie, Yujie Liu, Zhi Yao, Yingchi Zhang, Long Li   +7 more
doaj   +1 more source

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

EMBO Molecular Medicine, 2014
Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler, Sarah Mundt, Tony Muchamuel, Carlo Moll, Jing Jiang, Marcus Groettrup, Christopher J. Kirk   +6 more
doaj   +1 more source

Neuromyelitis Optica Spectrum Disorder Following Pituitary Tumor Resection: A Rare but Critical Differential in Neurosurgical Practice

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) is a rare, immune‐mediated astrocytopathy disorder that predominantly affects adults. Postoperative cases are scarcely reported. A 75‐year‐old woman underwent uncomplicated endoscopic resection of a nonfunctional pituitary macro‐adenoma.
Arad Iranmehr, Mohammad Shirani, Abdorreza Naser Moghadasi, Shirin Irani, Narges Akhlaghi, Samira Mirzaei, Hesam Ghadirian   +6 more
wiley   +1 more source

Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice [PDF]

, 2009
Background The involvement of astrocyte water channel aquaporin-4 (AQP4) in autoimmune diseases of the central nervous system has been suggested following the identification of AQP4 autoantibodies in neuromyelitis optica, an inflammatory demyelinating ...
AS Verkman, Zhang Hua, Hua Zhang, Verkman AS, Li Lihua, Zhang, Hua, Lihua Li, Verkman, AS, Li, Lihua   +8 more
core   +1 more source

LRP1 Activation Promotes Metabolic Reprogramming and Mrc1 Expression to Attenuate LPS‐Induced Cognitive Deficits: An Integrated Omics Analysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
LPS triggers neuroinflammation within the central nervous system. Conversely, the activation of LRP1 by SP16 mitigates insulin resistance, improves glucose metabolism, and facilitates the polarization of microglia toward an anti‐inflammatory M2‐like phenotype, which collectively contribute to the restoration of cognitive function.
Mengyao Qu, Yanan He, Lu Yu, Huikai Yang, Yixun Lu, Yingfu Li, Rui Wang, Miao Sun, Yulong Ma, Weidong Mi   +9 more
wiley   +1 more source

Development of IL-17A-associated autoimmunity

, 2010
Autoimmunity results from a breakdown in tolerance to self-antigens. Interleukin-17A (IL-17A) is a cytokine that has been implicated in the development of certain autoimmune disorders, notably multiple sclerosis and its mouse model experimental ...
Hornsby, E.
core  

Avaliação do papel dos receptores B1 e B2 para as cininas na modulação da encefalomielite autoimune experimental [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA Esclerose Múltipla (EM) é uma doença inflamatória crônica e progressiva, a qual desencadeia desmielinização no sistema ...
Dutra, Rafael Cypriano
core  

Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis

, 2005
Experimental autoimmune encephalomyelitis (EAE) is an animal model of inflammatory demyelination, a pathological event common to multiple sclerosis (MS). During CNS inflammation there are alterations in the extracellular matrix (ECM).
Woodroofe, N., Bunning, R. A D, Woodroofe, M. N., Plumb, J., Surr, J., Cross, A. K., Haddock, G., Buttle, D. J.   +7 more
core   +1 more source

Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

Neural Regeneration Research, 2018
The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the ...
Yuan Yue, Sarrabeth Stone, Wensheng Lin
doaj   +1 more source