Results 81 to 90 of about 49,920 (244)

miRNA profile is altered in a modified EAE mouse model of multiple sclerosis featuring cortical lesions

eLife, 2020
Cortical lesions represent a hallmark of multiple sclerosis and are proposed as a predictor of disease severity. microRNAs are suggested to be important players in the disease pathogenesis and the experimental autoimmune encephalomyelitis animal model ...
Nicola S Orefice, Owein Guillemot-Legris, Rosanna Capasso, Pauline Bottemanne, Philippe Hantraye, Michele Caraglia, Giuseppe Orefice, Mireille Alhouayek, Giulio G Muccioli   +8 more
doaj   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Labeling of immune cells for in vivo monitoring of cell migration using magnetic resonance imaging and near-infrared imaging [PDF]

, 2006
In addition to macrophage localization, the opening of the blood brain barrier (BBB) as well as demyelination processes have been measured by MRI mapping gadolinium (Gd) related signal enhancement and magnetic transfer (MT), respectively. By successively
Berger, Cedric
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Dietary carnosine intake improves outcomes in Experimental Autoimmune Encephalomyelitis

, 2019
Background: Carnosine (C9H14N4O3) is a naturally occurring dipeptide synthetized from histidine and β-alanine that is mainly found in excitable tissues such as skeletal muscle and the central nervous system (CNS).
Vanmierlo, T, Eijnde, BO, Franssen, W, Bogie, J, Derave, W, Spaas, J   +5 more
core   +1 more source

Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

eLife
Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). However, not all patients benefit from DMF.
Joanna Kosinska, Julian C Assmann, Julica Inderhees, Helge Müller-Fielitz, Kristian Händler, Sven Geisler, Axel Künstner, Hauke Busch, Anna Worthmann, Joerg Heeren, Christian D Sadik, Matthias Gunzer, Vincent Prévot, Ruben Nogueiras, Misa Hirose, Malte Spielmann, Stefan Offermanns, Nina Wettschureck, Markus Schwaninger   +18 more
doaj   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

Journal of Neuroinflammation, 2008
Background The purinergic receptor P2x7 is expressed on myeloid cells as well as on CNS glial cells, and P2x7 activation has been shown to increase both glial and T-cell activation. These properties suggest a role in the development of autoimmune disease
Lin Shao X, Simonini Vittoria, Polak Paul E, Sharp Anthony J, Richardson Jill C, Bongarzone Ernesto R, Feinstein Douglas L   +6 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis

, 2018
BACKGROUND: Muscle carnosine is related to contractile function (Ca++ handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS ...
Eijnde, Bert O., Missinne, Maarten, Van Noten, Pieter, Inez Wens, Blancquaert, Laura, Derave, Wim, Charly Keytsman, Laura Blancquaert, Pieter Van Noten, Bert O. Eijnde, Missine, Maarten, Keytsman, Charly, Maarten Missine, Frank Vandenabeele, Wim Derave, Eijnde, Bert O, Vandenabeele, Frank, Wens, Inez   +17 more
core   +1 more source