Results 141 to 150 of about 71,203 (273)
Journal of Lipid Research, 2009 The fungal pathogen Candida albicans transforms arachidonic acid (AA) into 3-hydroxyarachidonic acid [3(R)-HETE], and we investigated if its nonpathogenic and 3(R)-HETE-producing close relative, Dipodascopsis uninucleata, could similarly transform the ...
L. De Petrocellis +10 more
doaj +1 more source
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley +1 more source
Identification of Novel Predictive Biomarkers for Endometrial Malignancies: N-Acylethanolamines
Frontiers in Oncology, 2019 Objective: To identify new biochemical markers for endometrial cancer (EC). Recent evidence suggests that members of the endocannabinoid system (N-acylethanolamines) that bind to and activate receptors that are dysregulated in EC are involved in this ...
Thangesweran Ayakannu +8 more
doaj +1 more source
Progress in neurobiology, 2018 HighlightsMain aspects of neuroinflammation in multiple sclerosis.Metabolism and mechanisms of endocannabinoids summarized.Pathophysiological role of the different elements of the endocannabinoid system in multiple sclerosis and their therapeutic ...
V. Chiurchiù +3 more
semanticscholar +1 more source
How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle
Psychiatry and Clinical Neurosciences, EarlyView.Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang +3 more
wiley +1 more source
Frontiers in Immunology, 2018 Easy-to-achieve interventions to promote healthy longevity are desired to diminish the incidence and severity of infections, as well as associated disability upon recovery.
Ev Christin Heide +8 more
doaj +1 more source
Guessing at Ghosts in the Machine
Ratio, EarlyView.ABSTRACT As AI grows ever more complex and ubiquitous, its moral status becomes increasingly pressing. But knowing whether an AI has moral status is only part of the ethical puzzle. To determine how we ought to treat such entities, we must know not only whether AIs have moral status, but also about the content of their interests—what contributes to ...
Helen Yetter‐Chappell
wiley +1 more source
Involvement of TRPV1 Channels in Energy Homeostasis
Frontiers in Endocrinology, 2018 The ion channel TRPV1 is involved in a wide range of processes including nociception, thermosensation and, more recently discovered, energy homeostasis.
Stewart Christie +6 more
doaj +1 more source
Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature. [PDF]
, 2019 Fragile X syndrome (FXS) is an X-linked dominant disorder caused by a mutation in the fragile X mental retardation 1 gene. Cannabidiol (CBD) is an exogenous phytocannabinoid with therapeutic potential for individuals with anxiety, poor sleep, and ...
Bonn-Miller, Marcel +2 more
core
Endocannabinoids and Immunity [PDF]
Cannabis and Cannabinoid Research, 2016 Over the last 10 years, a great boost of knowledge accumulated on the immunomodulatory and anti-inflammatory properties of endocannabinoids (eCBs). In this scenario, these bioactive lipids, which are produced by most immune cells along with a set of receptors and enzymes that regulate their synthesis and degradation, act as secondary modulators and ...
openaire +2 more sources