Results 161 to 170 of about 41,114 (259)

Longitudinal changes in endocannabinoids and clinical course of adolescent non-suicidal self-injury. [PDF]

Transl Psychiatry
Ferger MD, Brodesser S, Kaess M, Koenig J.   +3 more
europepmc   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, Volume 14, Issue 6, Page 1472-1478, September 2026.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source

Cannabinoid and adenosine A2A receptor crosstalk regulates postnatal and adult hippocampal neurogenesis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5440-5457, September 2026.
Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues, Adam Armada‐Moreira, Laura Gómez‐Acero, Filipa F. Ribeiro, Francisco M. Mouro, Ana M. Sebastião, Francisco Ciruela, Ester Aso, Sara Xapelli   +8 more
wiley   +1 more source

Glucocorticoid-endocannabinoid crosstalk in the ventrolateral periaqueductal gray (vlPAG) promotes pain resolution. [PDF]

Neuropsychopharmacology
Coutens B, Bouchet CA, Gvon I, Patti LC, De Anda Gamboa CM, Jewett DC, Klawitter J, Klawitter J, Heinricher MM, Ingram SL.   +9 more
europepmc   +1 more source

Adolescent Exposure to a THC‐Rich Cannabis Extract Produces Genotype‐Dependent Effects on Cognition and Glial Morphology in Serine Racemase Mutant Mice

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
Adolescent exposure to a THC‐rich cannabis extract produced genotype‐dependent, contrasting effects in mice. In wild‐type animals, it altered behavior and brain glial cell structure, whereas in mice with a genetic deficiency in serine racemase, a model of impaired NMDA receptor signaling relevant to schizophrenia, it prevented cognitive and ...
Igor F. Rangel, Melissa Chaves, Iohanna Pagnoncelli, Isabelle Medeiros, Felipe Pinheiro, Lorena Fortuna, Luiza Castello‐Branco, Ernesto Diaz Roch, Virgínia Martins Carvalho, Flavia Regina Souza Lima, Rogério Panizzutti, Luciana Romão   +11 more
wiley   +1 more source

Exercise-induced anandamide-CB1R signaling and prefrontal-amygdala stress circuits in adolescent depression: a critical hypothesis-driven narrative review. [PDF]

Front Psychiatry
Luan Y, Wang S, Gao Y, Kong Q, Ma Z, Luan C.   +5 more
europepmc   +1 more source

Electrostatic tuning of NaV channel activation by the domain II S3–S4 extracellular loop

The Journal of Physiology, Volume 604, Issue 17, Page 7210-7224, 1 September 2026.
Abstract figure legend Voltage‐gated sodium (NaV) channels are critical for electrical signalling, yet the molecular determinants that tune isoform‐specific activation remain incompletely understood. Here, we show that charged amino acids in the extracellular DII S3–S4 loop of NaV1.7 play a key role in setting voltage‐dependent activation.
Ashvriya Thapa, Lotten Ragnarsson, Hue Tran, Angelo Keramidas, Jennifer R. Deuis, Irina Vetter   +5 more
wiley   +1 more source

N‐Arachidonoyl‐phosphatidylethanolamide phospholipase D activation by muscarinic receptors

The Journal of Physiology, Volume 604, Issue 18, Page 7721-7738, 15 September 2026.
Abstract figure legend Activating muscarinic M3 receptors activates Gq‐pathway signalling, including the activation of phospholipase C (PLC) and release of calcium from internal stores as shown in the upper panel. It remains unclear whether the calcium acts on N‐arachidonoyl‐phosphatidylethanolamide phospholipase D (NAPE‐PLD) itself or upstream at N ...
Natalia Murataeva, Connor Schmitt, Elyssa Hyman, Jim Wager‐Miller, Irene Matthews, Ruyi Cai, Shangxuan Cai, Yulong Li, Ken Mackie, Alex Straiker   +9 more
wiley   +1 more source

Corrigendum: Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect

Frontiers in Pharmacology
Stefania Petrosino, Stefania Petrosino, Marika Cordaro, Roberta Verde, Aniello Schiano Moriello, Aniello Schiano Moriello, Gabriele Marcolongo, Carlo Schievano, Rosalba Siracusa, Fabiana Piscitelli, Alessio F. Peritore, Rosalia Crupi, Daniela Impellizzeri, Emanuela Esposito, Salvatore Cuzzocrea, Vincenzo Di Marzo   +15 more
doaj   +1 more source

Cannabinoid type 1 receptor availability imaging in attention-deficit/hyperactivity disorder using [¹⁸F]MK-9470 positron emission tomography: study protocol of the CB1-ADHD study. [PDF]

EJNMMI Rep
Miederer I, Schofer ML, Ruckes C, Retz W, Schreckenberger M, Sebastian A.   +5 more
europepmc   +1 more source