Results 101 to 110 of about 26,170 (225)
The endocannabinoid system in sepsis – a potential target to improve microcirculation? [PDF]
Christine Lehmann +4 more
openalex +1 more source
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou +9 more
wiley +1 more source
The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach [PDF]
Romain Bourdy +7 more
openalex +1 more source
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou +14 more
wiley +1 more source
Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi +14 more
wiley +1 more source
The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans [PDF]
Ricardo Lacava Bailone +3 more
openalex +1 more source
Abstract There is a paucity of high‐quality evidence on the clinical efficacy of cannabis‐based medicinal products (CBMPs). The objective of this study was to perform trajectory k‐means clustering of health‐related quality of life (HRQoL) outcomes in patients prescribed CBMPs to identify distinct response patterns and baseline predictors of treatment ...
Simon Erridge +10 more
wiley +1 more source
Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity
ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien +4 more
wiley +1 more source
Interaction between endocannabinoids and the adrenergic system before and after stress-exposure
Hristina Nocheva +2 more
openalex +1 more source
FAM20C regulates the composition of the YTHDC1‐NCL‐KAP1‐LINE1 RNAs complex, thereby affecting neuronal differentiation in hypoxic–ischemic brain damage (HIBD). ABSTRACT Neurodevelopmental impairment due to hypoxic–ischemic brain damage (HIBD) lacks effective biomarkers and therapeutic targets.
Chen‐xi Feng +8 more
wiley +1 more source

