Results 81 to 90 of about 32,682 (238)

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Endocannabinoids modulate human blood–brain barrier permeability in vitro

British Journal of Pharmacology, 2015
Endocannabinoids alter permeability at various epithelial barriers, and cannabinoid receptors and endocannabinoid levels are elevated by stroke, with potential neuroprotective effects.
William H. Hind, C. Tufarelli, Maria Neophytou, S. Anderson, T. England, S. O’Sullivan   +5 more
semanticscholar   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Assessment of Cannabidiol Supplements Use in Small Animals Practice in Portugal

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study aimed to assess the current use of cannabidiol supplements (CBDS) by Portuguese small animal veterinary practitioners. An anonymous online survey questioning the frequency of CBDS use, purpose of use and the perceived outcome was developed using Microsoft Forms, and targeted veterinarians currently working in small animal clinics in
Maria Inês Santos, Ana Luísa Lourenço
wiley   +1 more source

Looking for trouble: A common threat‐detection mechanism underlying pain, fear, and anxiety

Mind &Language, EarlyView.
I put forward a novel cognitive architecture for pain, fear, and anxiety, according to which these three capacities are underpinned by a common threat‐detection mechanism. This mechanism takes information about potential threats as input, assesses whether the threat is actual and, if it deems it is, outputs a threat representation.
Luca Barlassina
wiley   +1 more source

Diet-induced changes in n-3 and n-6 derived endocannabinoids and reductions in headache pain and psychological distress

Journal of Pain, 2015
Omega-3 and omega-6 fatty acids are biosynthetic precursors to endocannabinoids with antinociceptive, anxiolytic, and neurogenic properties. We recently reported that targeted dietary manipulation—increasing omega-3 fatty acids while reducing omega-6 ...
Christopher E. Ramsden, Christopher E. Ramsden, Daisy Zamora, A. Makriyannis, J. Wood, J. D. Mann, K. Faurot, B. MacIntosh, Sharon F. Majchrzak-Hong, Jacklyn R. Gross, A. Courville, John M. Davis, J. Hibbeln   +12 more
semanticscholar   +1 more source

Established and Emerging Biomarkers to Characterize Persons at Risk for Obesity—Paving the Way for Targeted Clinical Intervention Trials—A Comprehensive Position Paper

Obesity Reviews, EarlyView.
ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid, Victoria Stopa, Laurent Malisoux, Yvan Devaux, Elsa Lamy, Fernando Capela e Silva, Sarah Forberger, Tiziana de Magistris, Antoni Sureda, Margalida Monserrat‐Mesquida, Maria Pérez‐Jiménez, Rajini Nagrani, Maria Giovanna Onorati, Michele Filippo Fontefrancesco, Jonathan Turner, Mahesh S. Desai, Josep Tur, Cristina Bouzas, Gino Gabriel Bonetti, Oliver Riedel, Gitte Ravn‐Haren, Rikke Andersen, Torsten Bohn   +22 more
wiley   +1 more source

Core decompression augmented with bone marrow aspirate concentrate for refractory distal sesamoid bone pathology in horses: A retrospective clinical study

Veterinary Surgery, EarlyView.
Abstract Objective To determine short‐ and long‐term outcomes of core decompression combined with autologous bone marrow aspirate concentrate (BMAC) in treating moderate‐to‐severe refractory distal sesamoid bone (DSB) trabecular pathology in horses. Study design Retrospective observational study. Animals A total of 21 client‐owned Warmblood horses with
Grigorios Maleas, Mahmoud Mageed, Kristyna Hargitaiova   +2 more
wiley   +1 more source

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

Experimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas, Cristián A. Amador, Susana Contreras‐Duarte   +2 more
wiley   +1 more source

Lipidomic Analysis of Endocannabinoid Signaling: Targeted Metabolite Identification and Quantification

Neural Plasticity, 2016
The endocannabinoids N-arachidonoylethanolamide (or anandamide, AEA) and 2-arachidonoylglycerol (2-AG) belong to the larger groups of N-acylethanolamines (NAEs) and monoacylglycerol (MAG) lipid classes, respectively.
Jantana Keereetaweep, Kent D. Chapman
doaj   +1 more source