Results 81 to 90 of about 19,236 (236)
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Leptin levels are negatively correlated with 2-arachidonoylglycerol in the cerebrospinal fluid of patients with osteoarthritis. [PDF]
PLoS ONE, 2015 There is compelling evidence in humans that peripheral endocannabinoid signaling is disrupted in obesity. However, little is known about the corresponding central signaling.
James Nicholson +9 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Changes of endocannabinoid plasma levels following type I trauma [PDF]
, 2012 The endocannabinoid system has emerged as one of the most important facilitators of stress adaptation in the body. So far, little to no research took place concerning the endocannabinoid response to stress in humans.
Heimendahl, Jenny von
core
Endocannabinoids, sperm functions and energy metabolism
, 2008 Cannabinoids, the main active components of marijuana, have been shown to exert different adverse effects on male reproduction both in vertebrates and invertebrates.
Marco, Rossato, ROSSATO, MARCO
core +1 more source
Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways
British Journal of Pharmacology, EarlyView.Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck +1 more
wiley +1 more source
PPAR Research, 2009 The aim of the present study was to examine whether endocannabinoids cause PPAR𝛾-mediated vascular actions. Functional vascular studies were carried out in rat aortae. Anandamide and N-arachidonoyl-dopamine (NADA), but not palmitoylethanolamide, caused
Saoirse E. O'Sullivan +2 more
doaj +1 more source
Endocannabinoids as Amyloid-Beta (Aβ) Aggregation Inhibitors [PDF]
, 2022 The endocannabinoid system, including endogenous cannabinoids and their corresponding receptors, has received extensive attention in the last few years for their neuroprotective effect in the central nervous system. The regulation and metabolism of these
Khavandi, Marzie
core
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Journal of Neuroinflammation, 2012 Background Several factors contribute to the deterioration in synaptic plasticity which accompanies age and one of these is neuroinflammation.
Murphy Niamh +10 more
doaj +1 more source