Results 101 to 110 of about 36,731 (276)
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]
, 2012 This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J. +6 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová +12 more
wiley +1 more source
Cortical and Striatal Circuits in Huntington's Disease
, 2020 Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
core +1 more source
Cannabinoids and the Endocannabinoid System in Early SARS-CoV-2 Infection and Long COVID-19—A Scoping Review [PDF]
, 2023 Cassidy Scott +3 more
openalex +1 more source
Cell Proliferation, EarlyView.LPC18:0 secreted by exogenous neural stem cells potentiates neurogenesis via the GPR55/AKT/GSK3β signalling axis, which ultimately promotes spinal cord injury recovery. ABSTRACT Spinal cord injury (SCI) is a devastating condition with limited therapeutic options. Although neural stem cell (NSC) transplantation shows regenerative potential, its efficacy
Dong Chen +11 more
wiley +1 more source
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2014 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F +3 more
core +3 more sources
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley +1 more source
The Evidence Behind the Diagnostic Investigation of Canine Idiopathic Epilepsy [PDF]
, 2016 Clinical bottom lineThere remains until recently an overall lack of clarity for the practical criteria for the diagnosis of canine idiopathic epilepsy.
Brodbelt, D C +2 more
core +2 more sources
Endocannabinoids and epilepsy [PDF]
, 2015 The brain endocannabinoid system (ECS) plays an essential role in regulating central physiological processes that underlie learning and memory, anxiety, depression, addiction, appetite and feeding, pain, neuronal excitability and protection. A primary mode through which the ECS functions in the brain is via its regulation of synaptic transmission ...
Blair, Robert +2 more
openaire +1 more source