Results 101 to 110 of about 32,682 (238)
Andrology, Volume 14, Issue 6, Page 1472-1478, September 2026.ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik +3 more
wiley +1 more source
Frontiers in Psychiatry, 2012 Schizophrenia is a complex psychiatric disorder strongly associated with substance use disorders. Theoretically, schizophrenia and SUD may share endocannabinoid alterations in the brain reward system.
Joelle eDesfossés +8 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 18, Page 5440-5457, September 2026.Background and purpose Adult neurogenesis is a tightly regulated process affected by both cannabinoid receptors (CB1 and CB2) and adenosine 2A (A2A) receptors, both of which modulate neural progenitor cell activity. While emerging evidence suggests an interaction between these neuromodulatory systems, the extent and mechanism of their interplay in ...
Rui S. Rodrigues +8 more
wiley +1 more source
Endocannabinoids in Synaptic Plasticity and Neuroprotection
The Neuroscientist, 2014 Endocannabinoids (eCBs) are endogenous lipid mediators involved in a variety of physiological, pharmacological, and pathological processes. While activation of the eCB system primarily induces inhibitory effects on both GABAergic and glutamatergic ...
Jian-Yi Xu, Chu Chen
semanticscholar +1 more source
mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling
Advanced Science, Volume 13, Issue 43, 3 August 2026.Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim +4 more
wiley +1 more source
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signaling
Nature Communications, 2014 Local environmental cues are indispensable for axonal growth and guidance during brain circuit formation. Here, we combine genetic and pharmacological tools, as well as systems neuroanatomy in human fetuses and mouse models, to study the role of ...
A. Alpár +16 more
semanticscholar +1 more source
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Sleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin (5‐HT) and sex, has not been directly tested.
Louis J. Kolling +14 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Electroacupuncture (EA) treatment has been utilized for recovery from neuromuscular‐related diseases and may play a significant role in the treatment of sarcopenia. This interventional, randomized controlled clinical study aims to explore the efficacy of EA treatment in maintenance haemodialysis (MHD) patients with sarcopenia ...
Ruoxin Chen +9 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle +7 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa +17 more
wiley +1 more source