Results 61 to 70 of about 32,682 (238)

The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review

Journal of Traditional and Complementary Medicine, 2023
Background and aim: Cannabis sativa L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from C. sativa L. with varieties of structures. Endocannabinoids exist in the human body.
Shan-Shan Zhang, Niu-Niu Zhang, Tian-Tian Guo, Lee-Yan Sheen, Chi-Tang Ho, Nai-Sheng Bai   +5 more
doaj   +1 more source

How much walking is enough for chronic low back pain? A systematic review and dose–response meta‐analysis

PM&R, EarlyView.
Abstract Objective To determine the dose–response relationship of a walking program and compare different delivery methods of walking exercise for patients with chronic low back pain (CLBP). Methods A systematic search of PubMed/MEDLINE, Web of Science, Scopus, Embase, and the Cochrane Library was conducted from inception to October 21, 2024.
Rodrigo Núñez‐Cortés, Luis Suso‐Martí, Joaquín Salazar‐Méndez, Rubén López‐Bueno, Carlos Cruz‐Montecinos, Tamara Malhue‐Orellana, Morin Lang, Lars Louis Andersen, Joaquín Calatayud   +8 more
wiley   +1 more source

ENDOCANNABINOIDS AND EICOSAMOIDS: BIOSYNTHESIS AND INTERACTIONS WITH IMMUNE RESPONSE

Медицинская иммунология, 2014
The review is dedicated to modern concepts of arachidonic acid metabolites, i.e., endocannabinoids and eicosanoids, their biosynthetic pathways, cross-talk mechanisms and participation in immune response.
Yu. K. Karaman, E. G. Lobanova
doaj   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Fatty Acid Modulation of the Endocannabinoid System and the Effect on Food Intake and Metabolism

International Journal of Endocrinology, 2013
Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system’s role in food intake and glucose and lipid metabolism.
Shaan S. Naughton, Michael L. Mathai, Deanne H. Hryciw, Andrew J. McAinch   +3 more
doaj   +1 more source

Comparative effectiveness, safety and acceptability of pharmacological and psychosocial interventions for the treatment of cannabis use disorder: A network meta‐analysis

Addiction, EarlyView.
Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka, Francesca Spiga, Tom P. Freeman, Suzanne Nielsen, Jelena Savović, Julian P. T. Higgins, Deborah M. Caldwell   +6 more
wiley   +1 more source

Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain

Molecular Pain, 2009
Activation of spinal microglia contributes to aberrant pain responses associated with neuropathic pain states. Endocannabinoids (ECs) are present in the spinal cord, and inhibit nociceptive processing; levels of ECs may be altered by microglia which ...
Elphick Maurice R, Barrett David, Eldeeb Khalil, Jhaveri Maulik, Richardson Denise, Guasti Leonardo, Alexander Stephen PH, Kendall David, Michael Gregory J, Chapman Victoria   +9 more
doaj   +1 more source

Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs

Frontiers in Pharmacology, 2016
Since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role of the cannabinoid system in immunity and the inflammatory response in human tissues and animal models.
Caroline Turcotte, Marie-Renée Blanchet, M. Laviolette, N. Flamand   +3 more
semanticscholar   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source