Results 61 to 70 of about 19,236 (236)
Autism Research, EarlyView.ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin +3 more
wiley +1 more source
The Potential of Inhibitors of Endocannabinoid Metabolism for Drug Development: A Critical Review
, 2015 The endocannabinoids anandamide and 2-arachidonoylglycerol are metabolised by both hydrolytic enzymes (primarily fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGL)) and oxygenating enzymes (e.g. cyclooxygenase-2, COX-2).
Fowler, Christopher J, +1 more
core +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota +8 more
wiley +1 more source
Scientific Reports, 2021 Endocannabinoids, particularly anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are instrumental in regulating energy homeostasis and stress response.
Isabel van Ackern +4 more
doaj +1 more source
The impact of phyto- and endo-cannabinoids on central nervous system diseases：A review
Journal of Traditional and Complementary Medicine, 2023 Background and aim: Cannabis sativa L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from C. sativa L. with varieties of structures. Endocannabinoids exist in the human body.
Shan-Shan Zhang +5 more
doaj +1 more source
Movement Disorders, EarlyView.Abstract Background Serotonergic and dopaminergic pathways are implicated in Parkinson's disease psychosis (PDP), but preliminary evidence also implicates the endocannabinoid system (ECS). Objectives We examined the association of gray matter volume loss in PDP patients with brain expression of the genes coding for CB1 (cannabinoid type 1) and CB2 ...
Sara Pisani +3 more
wiley +1 more source
Fatty Acid Modulation of the Endocannabinoid System and the Effect on Food Intake and Metabolism
International Journal of Endocrinology, 2013 Endocannabinoids and their G-protein coupled receptors (GPCR) are a current research focus in the area of obesity due to the system’s role in food intake and glucose and lipid metabolism.
Shaan S. Naughton +3 more
doaj +1 more source
Systematic Reviews, 2022 Background Increased circulating endocannabinoids levels are typically associated with aerobic exercise. This phenomenon is associated with a “runner’s high,” a state of euphoria and well-being experienced after a long exercise.
Viviane Bristot +5 more
doaj +1 more source
Disrupted endocannabinoid signaling contributes to systemic inflammation in acute pancreatitis
The Journal of Pathology, EarlyView.Abstract Acute pancreatitis (AP) is an inflammatory disease that can lead to systemic complications in severe cases. The endocannabinoid system has emerged as a potential modulator of inflammation in AP. We investigated the role of the endocannabinoid 2‐arachidonoylglycerol (2‐AG) and the cannabinoid receptors CB1 and CB2 during AP.
Paula Goncalves‐Romeu +7 more
wiley +1 more source
Endocannabinoids, adipose tissue and lipid metabolism
, 2008 Endocannabinoids regulate energy balance by modulating hypothalamic circuits controlling food intake and energy expenditure. However, convincing evidence has accumulated indicating that the endocannabinoid system is present also in peripheral tissues, in
C. Pagano +5 more
core +1 more source