Results 41 to 50 of about 32,682 (238)
Journal of Lipid Research, 2017 Endocannabinoids, a class of lipid messengers, have emerged as crucial regulators of synaptic communication in the CNS. Dysregulation of these compounds has been implicated in many brain disorders.
Vasudev Kantae +10 more
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Endocannabinoids and related N-acylethanolamines: biological activities and metabolism
Inflammation and Regeneration, 2018 The plant Cannabis sativa contains cannabinoids represented by Δ9-tetrahydrocannabinol, which exert psychoactivity and immunomodulation through cannabinoid CB1 and CB2 receptors, respectively, in animal tissues. Arachidonoylethanolamide (also referred to
K. Tsuboi, T. Uyama, Y. Okamoto, N. Ueda
semanticscholar +1 more source
Endocannabinoids and the processing of value-related signals
Frontiers in Pharmacology, 2012 Endocannabinoids serve as retrograde signaling molecules at many synapses within the CNS, particularly GABAergic and glutamatergic synapses. Synapses onto midbrain dopamine (DA) neurons in the ventral tegmental area (VTA) make no exception to this rule ...
Miriam eMelis +6 more
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The association of dietary patterns with endocannabinoids levels in overweight and obese women
Lipids in Health and Disease, 2020 Background Higher levels of anandamide (AEA) and 2-arachidonoylglycerol (2-AG), the main arachidonic acid-derived endocannabinoids, are frequently reported in overweight and obese individuals. Recently, endocannabinoids have become a research interest in
Neda Lotfi Yagin +4 more
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Scientific Reports, 2017 The endocannabinoid system is thought to modulate nociceptive signaling making it a potential therapeutic target for treating pain. However, there is evidence that endocannabinoids have both pro- and anti-nociceptive effects.
Torrie Summers +3 more
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Nutrition Journal, 2017 Background Besides the effects of dietary long chain PUFA on circulating endocannabinoids concentrations, the impact of other nutrients on these system is not known and, whether changes in plasma endocannabinoids levels correlated with changes in body ...
Fatemeh Haidari +3 more
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Endocannabinoid Overload [PDF]
Molecular Pharmacology, 2010 The signaling capacity of endogenous cannabinoids ("endocannabinoids") is tightly regulated by degradative enzymes. This Perspective highlights a research article in this issue (p. 996) in which the authors show that genetic disruption of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2 ...
Aron H, Lichtman +2 more
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Stress, 2011 Endogenous cannabinoids play an important role in the physiology and behavioral expression of stress responses. Activation of the hypothalamic-pituitary-adrenal (HPA) axis, including the release of glucocorticoids, is the fundamental hormonal response to stress. Endocannabinoid (eCB) signaling serves to maintain HPA-axis homeostasis, by buffering basal
Riebe, C., Wotjak, C.
openaire +3 more sources
Antioxidants, 2018 Growing evidence supports the pivotal role played by oxidative stress in tissue injury development, thus resulting in several pathologies including cardiovascular, renal, neuropsychiatric, and neurodegenerative disorders, all characterized by an altered ...
Cristina Anna Gallelli +9 more
semanticscholar +1 more source
Dietary triacylglycerols with palmitic acid in the sn-2 position modulate levels of N-acylethanolamides in rat tissues. [PDF]
PLoS ONE, 2015 Several evidences suggest that the position of palmitic acid (PA) in dietary triacylglycerol (TAG) influences different biological functions. We aimed at evaluating whether dietary fat with highly enriched (87%) PA in sn-2 position (Hsn-2 PA), by ...
Gianfranca Carta +8 more
doaj +1 more source