Results 31 to 40 of about 32,682 (238)

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT intervalResearch in context

EBioMedicine, 2023
Summary: Background: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown causes.
Irene Hiniesto-Iñigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin   +10 more
doaj   +1 more source

Beyond the Activity-Based Anorexia Model: Reinforcing Values of Exercise and Feeding Examined in Stressed Adolescent Male and Female Mice

Frontiers in Pharmacology, 2019
Anorexia nervosa (AN), mostly observed in female adolescents, is the most fatal mental illness. Its core is a motivational imbalance between exercise and feeding in favor of the former.
Imane Hurel, Imane Hurel, Bastien Redon, Bastien Redon, Amandine Scocard, Amandine Scocard, Meryl Malezieux, Meryl Malezieux, Giovanni Marsicano, Giovanni Marsicano, Francis Chaouloff, Francis Chaouloff   +11 more
doaj   +1 more source

Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play

Neuron, 2019
SUMMARY Brain sex differences are established developmentally and generate enduring changes in circuitry and behavior. Steroid-mediated masculinization of the rat amygdala during perinatal development produces higher levels of juvenile rough-and-tumble ...
Jonathan W. VanRyzin, Ashley E. Marquardt, Kathryn J Argue, Haley A. Vecchiarelli, Sydney E. Ashton, Sheryl E. Arambula, Matthew N Hill, M. McCarthy   +7 more
semanticscholar   +1 more source

An Operant Conditioning Task to Assess the Choice between Wheel Running and Palatable Food in Mice

Bio-Protocol, 2019
Wheel running, especially in the homecage, has been widely used to study the neurobiology of exercise because animal tends to use it voluntarily.
Bastien Redon, Imane Hurel, Giovanni Marsicano, Francis Chaouloff   +3 more
doaj   +1 more source

Endocannabinoid Turnover [PDF]

, 2017
In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited ...
Fowler, Christopher J., Doherty, Patrick, Alexander, Stephen P.H.   +2 more
openaire   +4 more sources

The Epigenetics of the Endocannabinoid System [PDF]

International Journal of Molecular Sciences, 2020
The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing machineries. The impairment of the ES has been associated to several pathological conditions like behavioural, neurological, or metabolic disorders and infertility, suggesting
Meccariello Rosaria, Santoro Antonietta, DʹAngelo Stefania, Morrone Rossella, Fasano Silvia, Viggiano Andrea, Pierantoni Riccardo   +6 more
openaire   +2 more sources

Emerging mechanisms by which endocannabinoids and their derivatives modulate bacterial populations within the gut microbiome

Advances in Drug and Alcohol Research, 2023
Bioactive lipids such as endocannabinoids serve as important modulators of host health and disease through their effects on various host functions including central metabolism, gut physiology, and immunity.
Melissa Ellermann
doaj   +1 more source

Serum contents of endocannabinoids are correlated with blood pressure in depressed women

Lipids in Health and Disease, 2012
Background Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in ...
Ho WS Vanessa, Hill Matthew N, Miller Gregory E, Gorzalka Boris B, Hillard Cecilia J   +4 more
doaj   +1 more source

Hair-based biomarkers in women with major depressive disorder: Glucocorticoids, endocannabinoids, N-acylethanolamines, and testosterone

Comprehensive Psychoneuroendocrinology, 2021
Background: Stress-related alterations in the regulation of several endocrine systems, including the hypothalamus-pituitary-adrenal (HPA) and -gonadal (HPG) axes and the endocannabinoid system are proposed to be involved in the etiology of major ...
Alexander Behnke, Anja M. Gumpp, Aniko Krumbholz, Alexandra M. Bach, Gustav Schelling, Iris-Tatjana Kolassa, Roberto Rojas   +6 more
doaj   +1 more source

Interaction between lysophosphatidic acid, prostaglandins and the endocannabinoid system during the window of implantation in the rat uterus.

PLoS ONE, 2012
Bioactive lipid molecules as lysophosphatidic acid (LPA), prostaglandins (PG) and endocannabinoids are important mediators of embryo implantation. Based on previous published data we became interested in studying the interaction between these three ...
Micaela S Sordelli, Jimena S Beltrame, Maximiliano Cella, María Gracia Gervasi, Silvina Perez Martinez, Juliana Burdet, Elsa Zotta, Ana M Franchi, María Laura Ribeiro   +8 more
doaj   +1 more source