Results 31 to 40 of about 20,782 (239)

Effects of parabolic flight and spaceflight on the endocannabinoid system in humans [PDF]

, 2012
The endocannabinoid system (ECS) plays an important role in the regulation of physiological functions, from stress and memory regulation to vegetative control and immunity.
Feuerecker, Matthias, Strewe, Claudia, Schelling, Gustav, Morukov, Boris, Chouker, Alexander, Nichiporuk, Igor, Kaufmann, Ines, Hauer, Daniela   +7 more
core   +1 more source

Endocannabinoid Overload [PDF]

Molecular Pharmacology, 2010
The signaling capacity of endogenous cannabinoids ("endocannabinoids") is tightly regulated by degradative enzymes. This Perspective highlights a research article in this issue (p. 996) in which the authors show that genetic disruption of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2 ...
Aron H, Lichtman, Jacqueline L, Blankman, Benjamin F, Cravatt   +2 more
openaire   +2 more sources

Hair-based biomarkers in women with major depressive disorder: Glucocorticoids, endocannabinoids, N-acylethanolamines, and testosterone

Comprehensive Psychoneuroendocrinology, 2021
Background: Stress-related alterations in the regulation of several endocrine systems, including the hypothalamus-pituitary-adrenal (HPA) and -gonadal (HPG) axes and the endocannabinoid system are proposed to be involved in the etiology of major ...
Alexander Behnke, Anja M. Gumpp, Aniko Krumbholz, Alexandra M. Bach, Gustav Schelling, Iris-Tatjana Kolassa, Roberto Rojas   +6 more
doaj   +1 more source

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Storr, Martin, Huber, Erasmus, Azad, Shahnaz C., Schelling, Gustav, Vogeser, Michael, Hauer, Daniela   +5 more
core   +1 more source

Interaction between lysophosphatidic acid, prostaglandins and the endocannabinoid system during the window of implantation in the rat uterus.

PLoS ONE, 2012
Bioactive lipid molecules as lysophosphatidic acid (LPA), prostaglandins (PG) and endocannabinoids are important mediators of embryo implantation. Based on previous published data we became interested in studying the interaction between these three ...
Micaela S Sordelli, Jimena S Beltrame, Maximiliano Cella, María Gracia Gervasi, Silvina Perez Martinez, Juliana Burdet, Elsa Zotta, Ana M Franchi, María Laura Ribeiro   +8 more
doaj   +1 more source

Metabolism of endocannabinoids

Postępy Higieny i Medycyny Doświadczalnej, 2016
Endocannabinoids belong to a group of ester, ether and amide derivatives of fatty acids, which are endogenous ligands of receptors CB1, CB2, TRPV1 and GPR55 that are included in the endocannabinoid system of the animal organism. The best known endocannabinoids are: N-arachidonylethanolamide called anandamide (AEA) and 2-arachidonoylglycerol (2-AG ...
Michał, Biernacki, Elżbieta, Skrzydlewska   +1 more
openaire   +2 more sources

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Andres Beiras Fernandez, Roland Toth, Markus Giehl, Weis, Florian, Erich Kilger, Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Schelling, Gustav, Florian Weis, Strewe, Claudia, Toth, Roland, Mirjam Schopp, Gustav Schelling, Daniela Hauer, Kilger, Erich, Schopp, Mirjam, Hauer, Daniela, Claudia Strewe   +18 more
core   +1 more source

Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS

Journal of Lipid Research, 2017
Endocannabinoids, a class of lipid messengers, have emerged as crucial regulators of synaptic communication in the CNS. Dysregulation of these compounds has been implicated in many brain disorders.
Vasudev Kantae, Shinji Ogino, Marek Noga, Amy C. Harms, Robin M. van Dongen, Gerrit L.J. Onderwater, Arn M.J.M. van den Maagdenberg, Gisela M. Terwindt, Mario van der Stelt, Michel D. Ferrari, Thomas Hankemeier   +10 more
doaj   +1 more source

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. [PDF]

, 2008
INTRODUCTION Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation.
Wittmann, Gábor, Korbonits, Márta, Farkas, Imre, Kola, Blerina, Fekete, Csaba, Grossman, Ashley B., Liposits, Zsolt, Harvey-White, Judith, Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Kunos, George   +11 more
core   +3 more sources

Endocannabinoids in neuroendopsychology: multiphasic control of mitochondrial function [PDF]

, 2012
The endocannabinoid system (ECS) is a construct based on the discovery of receptors that are modulated by the plant compound tetrahydrocannabinol and the subsequent identification of a family of nascent ligands, the 'endocannabinoids'.
Guy, G.W., Bell, JD, Nunn, A.V.W., Nunn, Alistair, Guy, G, Guy, Geoffrey, Nunn, A, Bell, Jimmy D, Bell, J.D.   +8 more
core   +1 more source