Results 11 to 20 of about 36,731 (276)
Endocannabinoids and Reproduction [PDF]
International Journal of Endocrinology, 2014 Infertility is a worldwide reproductive health problem whose consequences have deep psychological and social impact in health, demographic change, and wellbeing. Thus, the knowledge of basic, conserved modulators of reproduction might contribute to the discovery of new potential target for the exploitation of drugs to treat infertility in humans ...
Rosaria Meccariello +3 more
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Endocannabinoid Overload [PDF]
Molecular Pharmacology, 2010 The signaling capacity of endogenous cannabinoids ("endocannabinoids") is tightly regulated by degradative enzymes. This Perspective highlights a research article in this issue (p. 996) in which the authors show that genetic disruption of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2 ...
Aron H, Lichtman +2 more
openaire +2 more sources
Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Frontiers in Synaptic Neuroscience, 2022 Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses.
Riley T. Paulsen, Brian D. Burrell
doaj +1 more source
EBioMedicine, 2023 Summary: Background: Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown causes.
Irene Hiniesto-Iñigo +10 more
doaj +1 more source
Endocannabinoid Turnover [PDF]
, 2017 In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited ...
Fowler, Christopher J. +2 more
openaire +5 more sources
Frontiers in Pharmacology, 2019 Anorexia nervosa (AN), mostly observed in female adolescents, is the most fatal mental illness. Its core is a motivational imbalance between exercise and feeding in favor of the former.
Imane Hurel +11 more
doaj +1 more source
Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]
, 2012 Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Beiras-Fernandez, Andres +9 more
core +1 more source
An Operant Conditioning Task to Assess the Choice between Wheel Running and Palatable Food in Mice
Bio-Protocol, 2019 Wheel running, especially in the homecage, has been widely used to study the neurobiology of exercise because animal tends to use it voluntarily.
Bastien Redon +3 more
doaj +1 more source
The evolution and comparative neurobiology of endocannabinoid signalling [PDF]
, 2012 CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A. +4 more
core +1 more source
Advances in Drug and Alcohol Research, 2023 Bioactive lipids such as endocannabinoids serve as important modulators of host health and disease through their effects on various host functions including central metabolism, gut physiology, and immunity.
Melissa Ellermann
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