Results 31 to 40 of about 2,670,563 (294)

Endocrine Resistance in Hormone Receptor Positive Breast Cancer–From Mechanism to Therapy [PDF]

, 2019
The importance and role of the estrogen receptor (ER) pathway has been well-documented in both breast cancer (BC) development and progression. The treatment of choice in women with metastatic breast cancer (MBC) is classically divided into a variety of ...
Aradhana Rani (529007), Justin Stebbing, Giamas, G., Murphy, J.J., Justin Stebbing (181883), Georgios Giamas (4466365), Rani, A., John Murphy (1978417), Georgios Giamas, John Murphy, Stebbing, J., Aradhana Rani   +11 more
core   +1 more source

Endocrine therapy resistance: new insights [PDF]

The Breast, 2019
The estrogen receptor positive (ER+) subset is the dominant contributor to global deaths from breast cancer which now exceeds 500,000 deaths annually. Lethality is driven by endocrine resistance, which has been shown to be associated with high mutational rates and extreme subclonal diversity.
Jonathan T, Lei, Meenakshi, Anurag, Svasti, Haricharan, Xuxu, Gou, Matthew J, Ellis   +4 more
openaire   +2 more sources

Autophagy and endocrine resistance in breast cancer [PDF]

Expert Review of Anticancer Therapy, 2011
The American Cancer Society estimates that over 200,000 new breast cancer cases are diagnosed annually in the USA alone. Of these cases, the majority are invasive breast cancers and almost 70% are estrogen receptor-α positive. Therapies targeting the estrogen receptor-α are widely applied and include selective estrogen receptor modulators such as ...
Katherine L, Cook, Ayesha N, Shajahan, Robert, Clarke   +2 more
openaire   +2 more sources

The effects of bed rest and countermeasure exercise on the endocrine system in male adults: Evidence for immobilization-induced reduction in sex hormone-binding globulin levels [PDF]

, 2012
Background and Aim. There is limited data on the effects of inactivity (prolonged bed-rest) on parameters of endocrine and metabolic function; we therefore aimed to examine changes in these systems during and after prolonged (56-day) bed-rest in male ...
Rittweger, Jörn, Roth, H.J., Armbrecht, Gabriele, Felsenberg, Dieter, Seibel, Markus, Belavy, Daniel Ludovic   +5 more
core   +1 more source

Lapatinib in the Treatment of Hormone Receptor-Positive/ErbB2-Positive Breast Cancer [PDF]

, 2010
In women with estrogen receptor(ER)- and ErbB2(HER2)-positive breast cancer, a vicious cycle is established between ER mechanisms of action and the growth factor receptor network, leading to enhanced cell proliferation and endocrine resistance.
Bauerfeind, Ingo, Elling, Dirk, Heinemann, Volker   +2 more
core   +1 more source

Codon adaptation by synonymous mutations impacts the functional properties of the estrogen receptor‐alpha protein in breast cancer cells

Molecular Oncology, 2023
Oestrogen receptor‐alpha (ERα) positivity is intimately associated with the development of hormone‐dependent breast cancers. A major challenge in the treatment of these cancers is to understand and overcome the mechanisms of endocrine resistance ...
Léa Clusan, Frederic Percevault, Emmanuelle Jullion, Pascale Le Goff, Christophe Tiffoche, Tamara Fernandez‐Calero, Raphaël Métivier, Monica Marin, Farzad Pakdel, Denis Michel, Gilles Flouriot   +10 more
doaj   +1 more source

Skeletal Muscle Insulin Resistance in Endocrine Disease [PDF]

Journal of Biomedicine and Biotechnology, 2010
We summarize the existing literature data concerning the involvement of skeletal muscle (SM) in whole body glucose homeostasis and the contribution of SM insulin resistance (IR) to the metabolic derangements observed in several endocrine disorders, including polycystic ovary syndrome (PCOS), adrenal disorders and thyroid function abnormalities.
Peppa, M., Koliaki, C., Nikolopoulos, P., Raptis, S.A.   +3 more
openaire   +3 more sources

Introduction: The ecological relevance of chemically induced endocrine disruption in wildlife [PDF]

, 2006
This article is part of the monograph “The Ecological Relevance of Chemically Induced Endocrine Disruption in Wildlife.
Charles R. Tyler, Susan Jobling, Jobling, S, Tyler, CR   +3 more
core   +1 more source

Magnetic resonance imaging radiomics signatures for predicting endocrine resistance in hormone receptor-positive non-metastatic breast cancer

Breast, 2021
Background: One-third of patients with hormone receptor (HR)-positive breast cancers fail to respond to hormone therapy, and some patients even progress within two years of adjuvant endocrine therapy (ET) toward primary endocrine resistance.
Yaping Yang, Junwei Li, Yajing Liu, Ying Zhong, Wei Ren, Yujie Tan, Zifan He, Chenchen Li, Jie Ouyang, Qiugen Hu, Yunfang Yu, Herui Yao   +11 more
doaj   +1 more source

Predictive and Prognostic Value of Selected MicroRNAs in Luminal Breast Cancer

Frontiers in Genetics, 2019
Breast cancer (BrC) is the most frequent malignancy and the leading cause of cancer death among women worldwide. Approximately 70% of BrC are classified as luminal-like subtype, expressing the estrogen receptor.
Maria Amorim, Maria Amorim, João Lobo, João Lobo, João Lobo, Mário Fontes-Sousa, Mário Fontes-Sousa, Helena Estevão-Pereira, Helena Estevão-Pereira, Sofia Salta, Paula Lopes, Paula Lopes, Nuno Coimbra, Nuno Coimbra, Nuno Coimbra, Luís Antunes, Susana Palma de Sousa, Rui Henrique, Rui Henrique, Rui Henrique, Carmen Jerónimo, Carmen Jerónimo   +21 more
doaj   +1 more source