Results 11 to 20 of about 2,670,563 (294)
Molecular Mechanisms of Endocrine Resistance
, 2018 Estrogen receptor-positive (ER+) breast cancer is the most common subtype of breast cancer. Endocrine therapy targeting the ER pathway is effective, yet endocrine resistance is prevalent and remains a clinical challenge. The mechanisms underlying endocrine resistance are multifaceted and are likely to continue evolving over time in response to various ...
Fu X. +4 more
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Overcoming Endocrine Resistance in Breast Cancer
Current Cancer Drug Targets, 2010 Approximately 70% of breast cancers express the estrogen receptor (ER) and endocrine therapy is the most important component of systemic therapy for hormone-responsive breast cancer. Unfortunately, endocrine-resistant ER-positive disease represents up to one-quarter of all breast cancers and a number of different mechanisms have been implicated in ...
R. A. Madaio +5 more
openaire +4 more sources
Statins and endocrine resistance in breast cancer
Cancer Drug Resistance, 2021 Most breast cancers are hormone-receptor positive (HR+). However, more women eventually die from HR+ breast cancer than from either HER2+ or triple negative breast cancer. Endocrine therapies continue to be the mainstay of treatment. In 40% of these cases, recurrences in early-stage disease and progression in the metastatic setting are largely a ...
Hyder, Tara +3 more
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The changing role of ER in endocrine resistance
The Breast, 2015 Estrogen receptor (ER) is expressed in approximately 70% of newly diagnosed breast tumors. Although endocrine therapy targeting ER is highly effective, intrinsic or acquired resistance is common, significantly jeopardizing treatment outcomes and minimizing overall survival.
Nardone A. +4 more
openaire +4 more sources
ER-positive breast cancer cells are poised for RET-mediated endocrine resistance. [PDF]
PLoS ONE, 2018 The RET tyrosine kinase signaling pathway is involved in the development of endocrine resistant ER+ breast cancer. However, we know little about how ER+ cells activate RET signaling and initiate an endocrine resistant phenotype. Here we show that both ER+
Sachi Horibata +8 more
doaj +1 more source
F1000Research, 2022 Endocrine therapy resistance in Luminal Breast Cancer is a significant issue to be tackled, but currently, no specific biomarker could be used to anticipate this event.
Yohana Azhar +3 more
doaj +1 more source
Notch Signaling Pathway and Endocrine Resistance in Breast Cancer
Frontiers in Pharmacology, 2020 Nearly 70% of breast cancers express the estrogen receptor (ER) and are hormone-dependent for cell proliferation and survival. Anti-estrogen therapies with aromatase inhibitors (AIs), selective estrogen receptor modulators (SERMs) or selective estrogen ...
Jing-Wen Bai +6 more
doaj +1 more source
In vitro breast cancer models for studying mechanisms of resistance to endocrine therapy
Exploration of Targeted Anti-tumor Therapy, 2022 The development of endocrine resistance is a common reason for the failure of endocrine therapies in hormone receptor-positive breast cancer. This review provides an overview of the different types of in vitro models that have been developed as tools for
Gary J. Cheng +2 more
doaj +1 more source
Human epidermal growth factor receptor-2 and endocrine resistance in hormone-dependent breast cancer
, 2022 Endocrine therapies are the main treatment strategies for the clinical management of hormone-dependent breast cancer. Despite prolonged time to recurrence in the adjuvant setting and the initial clinical responses in the metastatic setting, many patients
Dowsett, Mitch +3 more
core +1 more source
Mechanisms of Endocrine Resistance in Breast Cancer [PDF]
Annual Review of Medicine, 2011 The estrogen receptor (ER) pathway plays a pivotal role in breast cancer development and progression. Endocrine therapy to block the ER pathway is highly effective, but its usefulness is limited by common intrinsic and acquired resistance. Multiple mechanisms responsible for endocrine resistance have been proposed and include deregulation of various ...
C Kent, Osborne, Rachel, Schiff
openaire +2 more sources