Results 91 to 100 of about 45,559 (245)

The Embryonic Development of the Cotylean Polyclad Phrikoceros jannetae

Acta Zoologica, EarlyView.
ABSTRACT Polyclads exhibit distinct developmental modes ranging from direct to indirect development, with several transitional stages also recognised. The existence of an indirect developmental mode in polyclads with a planktonic life history stage in the form of a free‐swimming larva is unique among all free‐living flatworms and makes polyclads a ...
Mehrez Gammoudi, Bernhard Egger, Isabel L. Dittmann, Verónica N. Bulnes, Pavel Tomancak, Abdel Halim Harrath, Johannes Girstmair   +6 more
wiley   +1 more source

Heterodimers reign in the embryo

eLife, 2017
Experiments by three independent groups on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of ...
Benjamin Tajer, Mary C Mullins
doaj   +1 more source

Paradoxical Role of DNA Methylation in Activation of FoxA2 Gene Expression during Endoderm Development*

Journal of Biological Chemistry, 2014
Background: The transcription factor FoxA2 is a key mediator of endoderm development and pancreas gene expression. Results: DNA methylation is paradoxically associated with active expression of the FoxA2 gene. Conclusion: Developmental control genes such
K. Bahar Halpern, Tal Vana, M. Walker
semanticscholar   +1 more source

Development of NAFLD‐Specific Human Liver Organoid Models on a Microengineered Array Chip for Semaglutide Efficacy Evaluation

Cell Proliferation, EarlyView.
Microporous array organ chips were integrated with commercially available well plates to develop organoid chip platforms, which enable modelling of hepatic physiology and non‐alcoholic fatty liver disease (NAFLD) pathogenesis, as well as evaluation of semaglutide therapeutics. ABSTRACT Progressive non‐alcoholic fatty liver disease (NAFLD) may culminate
Xiao‐yan You, Xiang‐yang Li, Hui Wang, Guo‐ping Zhao   +3 more
wiley   +1 more source

Sensing oxygen inside and out

eLife, 2017
Neuroendocrine cells act as oxygen sensors in animals from fish to humans, but the evolutionary origins of these cells are only just becoming clear.
Maria R Stupnikov, Wellington V Cardoso
doaj   +1 more source

Identification of Common Blood Metabolic Derangements Using Magnetic Resonance Signatures of the Pancreas and Liver

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To investigate whether common disturbances of glucose and lipid metabolism can be automatically identified from magnetic resonance signatures of the pancreas and liver. Methods In this proof‐of‐principle study, 100 individuals with a history of pancreatitis—a relatively homogeneous population at risk for metabolic derangements—underwent ...
Wandia Kimita, Juyeon Ko, Loren Skudder‐Hill, Xiatiguli Shamaitijiang, Yutong Liu, Maxim S. Petrov   +5 more
wiley   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

Equine Veterinary Journal, EarlyView.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez, Alejandro de la Fuente, Kazuki Takahashi, Hugo Monteiro, Mauricio Mendes, Stuart Meyers, Pouya Dini   +6 more
wiley   +1 more source

Retinoic Acid and the Development of the Endoderm

Journal of Developmental Biology, 2015
Retinoic acid (RA) is an important signaling molecule in the development of the endoderm and an important molecule in protocols used to generate endodermal cell types from stem cells.
Gregory M. Kelly, Thomas A. Drysdale
doaj   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

The dental plate on bichir pectoral fins: A unique dermal skeletal element bearing individual odontodes with tooth‐like replacement

Journal of Anatomy, EarlyView.
Pectoral fins of bichirs encompass the so‐called dental plates – unique dermal skeletal elements with individual odontodes identical to the oral teeth. Abstract The dermal skeleton appeared early in vertebrate evolution in the form of mineralized skin denticles composed of tooth‐like units—odontodes.
Tomáš Suchánek, Ann Huysseune, Robert Cerny   +2 more
wiley   +1 more source