Results 51 to 60 of about 45,559 (245)

Mechanisms of endoderm formation in a cartilaginous fish reveal ancestral and homoplastic traits in jawed vertebrates

Biology Open, 2014
In order to gain insight into the impact of yolk increase on endoderm development, we have analyzed the mechanisms of endoderm formation in the catshark S. canicula, a species exhibiting telolecithal eggs and a distinct yolk sac.
Benoit G. Godard, Marion Coolen, Sophie Le Panse, Aurélie Gombault, Susana Ferreiro-Galve, Laurent Laguerre, Ronan Lagadec, Patrick Wincker, Julie Poulain, Corinne Da Silva, Shigehiro Kuraku, Wilfrid Carre, Agnès Boutet, Sylvie Mazan   +13 more
doaj   +1 more source

Oral and Palatal Dentition of Axolotl Arises From a Common Tooth-Competent Zone Along the Ecto-Endodermal Boundary

Frontiers in Cell and Developmental Biology, 2021
Vertebrate dentitions arise at various places within the oropharyngeal cavity including the jaws, the palate, or the pharynx. These dentitions develop in a highly organized way, where new tooth germs are progressively added adjacent to the initiator ...
Vladimír Soukup, Akira Tazaki, Akira Tazaki, Yosuke Yamazaki, Anna Pospisilova, Hans-Henning Epperlein, Elly M. Tanaka, Elly M. Tanaka, Robert Cerny   +8 more
doaj   +1 more source

OSKM Induce Extraembryonic Endoderm Stem Cells in Parallel to Induced Pluripotent Stem Cells

Stem Cell Reports, 2016
Summary The reprogramming factors OCT4, SOX2, KLF4, and MYC (OSKM) can reactivate the pluripotency network in terminally differentiated cells, but also regulate expression of non-pluripotency genes in other contexts, such as the mouse primitive endoderm.
Anthony Parenti, Michael A. Halbisen, Kai Wang, K. Latham, A. Ralston   +4 more
semanticscholar   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Aptly Named Visceral Endoderm [PDF]

Developmental Cell, 2008
The very early mouse embryo is initially covered by a layer of cells called visceral endoderm that despite its name (visceral means associated with internal organs) was only thought to give rise to extraembryonic structures. Now, in this issue of Developmental Cell, Kwon et al. (2008) show unexpectedly that a significant population of visceral endoderm
openaire   +2 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Development of Functional Thyroid C Cell-like Cells from Human Pluripotent Cells in 2D and in 3D Scaffolds

Cells, 2021
Medullary thyroid carcinoma contributes to about 3–4% of thyroid cancers and affects C cells rather than follicular cells. Thyroid C cell differentiation from human pluripotent stem cells has not been reported.
Kwaku Dad Abu-Bonsrah, Donald F. Newgreen, Mirella Dottori   +2 more
doaj   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Genome-Wide Epigenetic Characterization of Tissues from Three Germ Layers Isolated from Sheep Fetuses

Frontiers in Genetics, 2017
DNA methylation of regulatory and growth-related genes contributes to fetal programming which is important for maintaining the correct development of three germ layers of the embryo that develope into different tissues and organs, and which persists into
Emanuele Capra, Paola Toschi, Marcello Del Corvo, Marcello Del Corvo, Barbara Lazzari, Barbara Lazzari, Pier A. Scapolo, Pasqualino Loi, John L. Williams, Alessandra Stella, Alessandra Stella, Paolo Ajmone-Marsan   +11 more
doaj   +1 more source

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

eLife, 2020
Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers.
Shreyasi Mukherjee, Praneet Chaturvedi, Scott A Rankin, Margaret B Fish, Marcin Wlizla, Kitt D Paraiso, Melissa MacDonald, Xiaoting Chen, Matthew T Weirauch, Ira L Blitz, Ken WY Cho, Aaron M Zorn   +11 more
doaj   +1 more source