Results 101 to 110 of about 10,232 (247)

Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model

Journal of Biomedical Sciences
This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-PA90, designed to combat these challenges ...
Jeonghyun Lim, Heejoon Myung, Daejin Lim, Miryoung Song   +3 more
semanticscholar   +1 more source

Engineered endolysin-based "artilysins" to combat multidrug-resistant gram-negative pathogens [PDF]

, 2014
The global threat to public health posed by emerging multidrug-resistant bacteria in the past few years necessitates the development of novel approaches to combat bacterial infections.
Brenner, Briers, Briers, Briers, Briers, Briers, Cenens, Church, De Corte, Delcour, Düring, Gasson, Haun, Holloway, Ibrahim, Ibrahim, Ibrahim, Ibrahim, Kümmerer, Lavigne, Loeffler, Lukacik, Masschalck, Morita, Moy, Nelson, Nelson, Nikaido, Park, Pastagia, Pirnay, Pirnay, Raetz, Schmelcher, Schuch, Stiernagle, Tan, Vaara, Walmagh, Walmagh, Yan   +40 more
core   +4 more sources

Update of the list of QPS‐recommended biological agents intentionally added to food or feeds as notified to EFSA

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety concerns of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Marianne Chemaly, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Ingvar Sundh, Fulvio Barizzone, Justine Dastouet, Nadya Doyle, Sandra Correia, Lieve Herman   +28 more
wiley   +1 more source

Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections

Journal of Biomedical Sciences
Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter baumannii or cephalosporin-resistant Enterobacteriaceae.
D.V. Vasina, N. Antonova, V. Gushchin, A. Aleshkin, M. Fursov, A. D. Fursova, P. Gancheva, I. V. Grigoriev, Pavel Grinkevich, Alexey V Kondratev, Alexey V. Kostarnoy, A. M. Lendel, V. V. Makarov, M. Nikiforova, A. Pochtovyi, Tatiana Prudnikova, Timofey A. Remizov, N. Shevlyagina, Andrei E. Siniavin, Nina S. Smirnova, Alexander A Terechov, A. Tkachuk, E. V. Usachev, A. M. Vorobev, Victoria S. Yakimakha, Sergey M. Yudin, Anastasia A Zackharova, V. Zhukhovitsky, D. Logunov, A. L. Gintsburg   +29 more
semanticscholar   +1 more source

Nanostructured Protein Surfaces Inspired by Spider Silk

Advanced Materials, Volume 37, Issue 51, December 23, 2025.
Harnessing recombinant spider silk technology, bioengineered spidroin variants enable the creation of functionalized nanostructured coatings with tunable affinity for specific targets, supporting a broad range of applications ‐ from antifouling surfaces and targeted drug delivery to advanced cell therapies and precision bio‐patterning via lithography ...
Martin Humenik, Thomas Scheibel
wiley   +1 more source

A Novel Phage PD-6A3, and Its Endolysin Ply6A3, With Extended Lytic Activity Against Acinetobacter baumannii

Frontiers in Microbiology, 2019
With widespread abuse of antibiotics, bacterial resistance has increasingly become a serious threat. Acinetobacter baumannii has emerged as one of the most important hospital-acquired pathogens worldwide.
Minle Wu, Kongying Hu, Youhua Xie, Yili Liu, Di Mu, Huimin Guo, Zhifan Zhang, Yingcong Zhang, Dong Chang, Yi Shi   +9 more
doaj   +1 more source

Molecular characterization of the PhiKo endolysin from Thermus thermophilus HB27 bacteriophage phiKo and its cryptic lytic peptide RAP-29

Frontiers in Microbiology
Introduction In the era of increasing bacterial resistance to antibiotics, new bactericidal substances are sought, and lysins derived from extremophilic organisms have the undoubted advantage of being stable under harsh environmental conditions.
Monika Szadkowska, A. Kocot, Daria Sowik, Dariusz Wyrzykowski, Elżbieta Jankowska, Lukasz Pawel Kozlowski, Joanna Makowska, M. Płotka   +7 more
semanticscholar   +1 more source

The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges

Advanced Genetics, Volume 6, Issue 4, December 2025.
This article examines how the respiratory virome contributes to health and disease, highlighting its interactions with the host and bacteriome. Key disease associations and present knowledge gaps are outlined. The review discusses challenges in sample collection and preprocessing, and presents future research directions for understanding virome ...
Xiaoxuan Yao, Xiaohui Zou, Bin Cao
wiley   +1 more source

The antibacterial activity of a novel highly thermostable endolysin, LysKP213, against Gram-negative pathogens is enhanced when combined with outer membrane permeabilizing agents

Frontiers in Microbiology
Phages and phage-encoded lytic enzymes are promising antimicrobial agents. In this study, we report the isolation and identification of bacteriophage KP2025 from Klebsiella pneumoniae.
Dingjian Chu, Jing Lan, Lu Liang, Kaide Xia, Linlin Li, Lan Yang, Hongmei Liu, Tingting Zhang   +7 more
semanticscholar   +1 more source

Antibacterial activity on opportunistic Pseudomonas aeruginosa pathogen by a novel Salmonella phage endolysin [PDF]

, 2011
The Gram-negative pathogen Pseudomonas aeruginosa can cause severe infections of burn wound or cystic fibrosis on patients. Bacteriophage endolysin based strategy can offer a new alternative antimicrobial therapy.
Azeredo, Joana, Kluskens, Leon, Lavigne, Rob, Oliveira, Hugo Alexandre Mendes, Sillankorva, Sanna, Walmagh, Maarten   +5 more
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