Results 11 to 20 of about 10,232 (247)
Endolysin Regulation in Phage Mu Lysis
mBio, 2022 Bacteriophage Mu is a paradigm coliphage studied mainly because of its use of transposition for genome replication. However, in extensive nonsense mutant screens, only one lysis gene has been identified, the endolysin gp22.
Jake S. Chamblee +7 more
doaj +3 more sources
Molecular aspects and comparative genomics of bacteriophage endolysins [PDF]
Journal of Virology, 2013 Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is predominantly determined by their dynamic adaptation capacities, when confronted with different selective pressures in an endless cycle of co-evolution with
Azeredo, Joana +7 more
core +6 more sources
Endolysin, a Promising Solution against Antimicrobial Resistance [PDF]
Antibiotics, 2021 Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases.
M. Rahman +9 more
semanticscholar +4 more sources
Phage-Encoded Endolysins [PDF]
Antibiotics, 2021 Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from within. There is significant evidence that proves the ability of endolysins to degrade the peptidoglycan
Fatma Abdelrahman +11 more
openaire +5 more sources
The short cytoplasmic region of phage T4 holin is essential for the transition from impermeable membrane protein complexes to permeable pores [PDF]
Frontiers in MicrobiologyVirulent as well as temperate phages usually require lysis of bacteria to release their progeny into the surrounding. Double-stranded DNA phages achieve lysis by phage-encoded endolysins that degrade the bacterial cell wall.
Jan Michel Frederik Schwarzkopf +5 more
doaj +2 more sources
Characterisation of a Novel Jumbo Lytic Aeromonas dhakensis Bacteriophage P19 and Its Endolysin. [PDF]
Microb BiotechnolA jumbo, lytic myovirus phage P19 against multidrug‐resistant (MDR) Aeromonas dhakensis was isolated from river water. P19 demonstrated robust lytic activity, high thermal and pH stability (pH 6–10, up to 60°C), and no genes associated with lysogeny, virulence or antimicrobial resistance. ORF_358 of P19 encodes for T4‐type lysozyme.
Ansari F, Nagar V.
europepmc +2 more sources
Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications. [PDF]
MicrobiologyopenThis study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Paul JK +6 more
europepmc +2 more sources
Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE-M6 as Potential Antibacterial Agents. [PDF]
MicrobiologyopenWe isolated phage UE‐M6 from wastewater and subsequently cloned, expressed, and purified its encoded endolysin (UE‐lysin) and holin (UE‐holin). Our results demonstrate that the combined application of UE‐lysin and UE‐holin exhibits significantly greater antibacterial activity than either protein alone, indicating a synergistic interaction between the ...
Niaz H, Skurnik M, Adnan F.
europepmc +2 more sources
Microbiology Spectrum, 2022 Endolysin is a phage-encoded cell-wall hydrolase which degrades the peptidoglycan layer of the bacterial cell wall. The enzyme is often expressed at the late stage of the phage lytic cycle and is required for progeny escape.
Wichuda Phothichaisri +6 more
doaj +1 more source
Antibiotics, 2022 Staphylococcus aureus, a pathogenic species of genus Staphylococcus involved in foodborne illness always remain among the top priorities of the world major concerns.
Seon-Gyu Kim +4 more
doaj +1 more source