Results 51 to 60 of about 10,232 (247)
AMB Express, 2019 Drug-resistant bacteria are a serious threat to global public health. Gram-positive bacterial endolysin preparations have been successfully used to fight Gram-positive bacteria as a novel antimicrobial replacement strategy.
Guangmou Yan +8 more
doaj +1 more source
Expression and delivery of an endolysin to combat Clostridium perfringens [PDF]
, 2013 Clostridium perfringens is a cause for increasing concern due to its responsibility for severe infections both in humans and animals, especially poultry. To find new control strategies to treat C.
Arjan Narbad +5 more
core +1 more source
Combination Effect of Engineered Endolysin EC340 With Antibiotics [PDF]
Frontiers in Microbiology, 2022 Bacteriophage lysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages during the final stage of the lytic cycle to enable cleavage through the host’s cell wall, thus allowing the phages to burst out of their host bacteria after multiplication inside them. When applied externally to Gram-negative bacteria
Hye-Won Hong +8 more
openaire +3 more sources
The Holin-Endolysin Lysis System of the OP2-Like Phage X2 Infecting Xanthomonas oryzae pv. oryzae
Viruses, 2021 Most endolysins of dsDNA phages are exported by a holin-dependent mechanism, while in some cases endolysins are exported via a holin-independent mechanism.
Zhifeng Wu +9 more
doaj +1 more source
The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor.
PLoS Pathogens, 2014 The bacteriophage ΦCD27 is capable of lysing Clostridium difficile, a pathogenic bacterium that is a major cause for nosocomial infection. A recombinant CD27L endolysin lyses C. difficile in vitro, and represents a promising alternative as a bactericide.
Matthew Dunne +9 more
doaj +1 more source
Validation of the method for determining the specific activity of the gel with recombinant endolysin [PDF]
BIO Web of Conferences, 2021 A method for determining the specific bactericidal activity of the gel with the recombinant modified endolysin of the bacteriophage ECD7 has been developed.
Vorobev Alexey +7 more
doaj +1 more source
Bacteriophage Endolysins and their Applications
Science Progress, 2016 Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant.
Jude, Ajuebor +5 more
openaire +2 more sources
Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection
BMC Microbiology, 2011 Background Interest in phage therapy has grown over the past decade due to the rapid emergence of antibiotic resistance in bacterial pathogens. However, the use of bacteriophages for therapeutic purposes has raised concerns over the potential for immune ...
Kempashanaiah Nanjundappa +7 more
doaj +1 more source
Formation of therapeutic phage cocktail and endolysin to highly multi-drug resistant Acinetobacter baumannii: in vitro and in vivo study [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Phage therapy is a potential alternative treatment for infections caused by Acinetobacter baumannii, a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and ...
Hayder Nsaif Jasim +2 more
doaj +1 more source
Foods, 2023 Clostridium perfringens is a gram-positive, anaerobic, spore-forming bacterium capable of producing four major toxins which cause disease symptoms and pathogenesis in humans and animals. C.
Rui Lu +7 more
semanticscholar +1 more source