Results 71 to 80 of about 10,232 (247)

A Thermophilic Phage Endolysin Fusion to a Clostridium perfringens-Specific Cell Wall Binding Domain Creates an Anti-Clostridium Antimicrobial with Improved Thermostability

Viruses, 2015
Clostridium perfringens is the third leading cause of human foodborne bacterial disease and is the presumptive etiologic agent of necrotic enteritis among chickens. Treatment of poultry with antibiotics is becoming less acceptable.
Steven M. Swift, Bruce S. Seal, Johnna K. Garrish, Brian B. Oakley, Kelli Hiett, Hung-Yueh Yeh, Rebekah Woolsey, Kathleen M. Schegg, John Eric Line, David M. Donovan   +9 more
doaj   +1 more source

The Unique Capability of Endolysin to Tackle Antibiotic Resistance: Cracking the Barrier

Journal of Xenobiotics
The lack of new antibacterial medicines and the rapid rise in bacterial resistance to antibiotics pose a major threat to individuals and healthcare systems.
Abdus Sabur, Angkan Khan, B. Borphukan, Abdur Razzak, M. Salimullah, Muslima Khatun   +5 more
semanticscholar   +1 more source

Pseudomonas Phage ZCPS1 Endolysin as a Potential Therapeutic Agent

Viruses, 2023
The challenge of antibiotic resistance has gained much attention in recent years due to the rapid emergence of resistant bacteria infecting humans and risking industries. Thus, alternatives to antibiotics are being actively searched for.
Fatma Abdelrahman, Rutuja Gangakhedkar, Gokul Nair, Gamal El–Didamony, A. Askora, V. Jain, Ayman El-Shibiny   +6 more
semanticscholar   +1 more source

Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms [PDF]

, 2016
Many bacteria produce extracellular and surface-associated components such as membrane vesicles (MVs), extracellular DNA and moonlighting cytosolic proteins for which the biogenesis and export pathways are not fully understood.
Ahrens, CH, Cavaliere, R, Charles, IG, Cárcamo-Oyarce, G, Eberl, L, Gloag, ES, Hynen, AL, Ito, S, Kurosawa, M, Monahan, LG, Nomura, N, Omasits, U, Osvath, SR, Pessi, G, Petty, NK, Shimoni, R, Toyofuku, M, Turnbull, L, Whitchurch, CB, Yap, X   +19 more
core   +1 more source

Bioinformatic Analysis of Prophage Endolysins and Endolysin-Like Genes from the Order Lactobacillales

Nova Biotechnologica et Chimica, 2012
Bioinformatic Analysis of Prophage Endolysins and Endolysin-Like Genes from the Order Lactobacillales Endolysins belonging to the group of peptigoglycan hydrolases, which are able to cleave peptidoglycan in bacterial cell walls, become an extensively studied group of enzymes.
Lenka Maliničová, Peter Pristaš, Peter Javorský   +2 more
openaire   +1 more source

Engineering of lysin by fusion of antimicrobial peptide (cecropin A) enhances its antibacterial properties against multidrug-resistant Acinetobacter baumannii

Frontiers in Microbiology, 2022
Most clinical isolates of Acinetobacter baumannii, a nosocomial pathogen, are multidrug-resistant (MDR), fueling the search for alternative therapies.
Md Maidul Islam, Dooyoung Kim, Kyeongmin Kim, Su-Jin Park, Samia Akter, Jeongah Kim, Seunghyeok Bang, Shukho Kim, Jungmin Kim, Je Chul Lee, Chang-Won Hong, Minsang Shin   +11 more
doaj   +1 more source

Bacteriophage endolysins as a response to emerging foodborne pathogens [PDF]

, 2012
Continuous reports on foodborne outbreaks and increasing prevalence of antibiotic-resistant bacteria call for the development of novel preservation techniques that assure the safety of food products.
Azeredo, Joana, Kluskens, Leon, Lavigne, Rob, Oliveira, Hugo Alexandre Mendes   +3 more
core   +1 more source

Defense Systems and Prophage Detection in Streptococcus mutans Strains

Molecular Oral Microbiology, EarlyView.
ABSTRACT Although the species is extensively studied, limited data are available on antiphage defense systems (APDSs) in Streptococcus mutans. The present study aimed to explore the diversity and the occurrence of APDSs and to search for prophages in the genomes of clinical isolates of S. mutans using bioinformatics tools.
Olivier Claisse, Cas Mosterd, Claire Le Marrec, Johan Samot   +3 more
wiley   +1 more source

A Novel Antimicrobial Endolysin, LysPA26, against Pseudomonas aeruginosa [PDF]

Frontiers in Microbiology, 2017
The global increase in multidrug resistant (MDR) bacteria has led to phage therapy being refocused upon. A novel endolysin, LysPA26, containing a lysozyme-like domain, was screened against Pseudomonas aeruginosa in this study. It had activity against MDR P. aeruginosa without pretreatment with an outer-membrane permeabilizer. LysPA26 could kill up to 4
Guo, Mingquan, Feng, Chunyan, Ren, Jie, Zhuang, Xuran, Zhang, Yan, Zhu, Yongzhang, Dong, Ke, He, Ping, Guo, Xiaokui, Qin, Jinhong   +9 more
openaire   +2 more sources

Peptidoglycan-Free Bacterial Ghosts Confer Enhanced Protection against Yersinia pestis Infection

Vaccines, 2021
To develop a modern plague vaccine, we used hypo-endotoxic Yersinia pestis bacterial ghosts (BGs) with combinations of genes encoding the bacteriophage ɸX174 lysis-mediating protein E and/or holin-endolysin systems from λ or L-413C phages.
Svetlana V. Dentovskaya, Anastasia S. Vagaiskaya, Mikhail E. Platonov, Alexandra S. Trunyakova, Sergei A. Kotov, Ekaterina A. Krasil’nikova, Galina M. Titareva, Elizaveta M. Mazurina, Tat’yana V. Gapel’chenkova, Rima Z. Shaikhutdinova, Sergei A. Ivanov, Tat’yana I. Kombarova, Vladimir N. Gerasimov, Vladimir N. Uversky, Andrey P. Anisimov   +14 more
doaj   +1 more source