Results 61 to 70 of about 4,149 (194)
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq +4 more
wiley +1 more source
Regulation of a Phage Endolysin by Disulfide Caging [PDF]
ABSTRACT In contrast to canonical phage endolysins, which require holin-mediated disruption of the membrane to gain access to attack the cell wall, signal anchor release (SAR) endolysins are secreted by the host sec system, where they accumulate in an inactive form tethered to the membrane by their N ...
Gabriel F, Kuty +4 more
openaire +2 more sources
Bacteriophages offer targeted, self‐limiting control of intestinal pathogens in livestock and poultry. This review integrates their biological properties, mechanisms of gut‐health promotion, key experimental evidence, application strategies, and current challenges, outlining a path toward sustainable animal production and global food security ...
Manman Song +6 more
wiley +1 more source
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
Investigation of bacteriophage endolysins activity. [PDF]
Because of rapid growth of bacterial resistance to various antibiotics, it is necessary to discover alternatives to kill bacteria. Bacteriophages were considered as an opportunity for long time, but since bacteria also became resistant to them, attention
Cicilionytė, Aurelija,
core
Bacteriophage endolysins have attracted attention as promising alternatives to antibiotics, and their modular structure facilitates endolysin engineering to develop novel endolysins with enhanced versatility.
Bokyung Son +4 more
doaj +1 more source
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen +2 more
wiley +1 more source
Diversity of Endolysin Domain Architectures in Bacteriophages Infecting Bacilli
The increasing number of antibiotic-resistant bacterial pathogens is a serious problem in medicine. Endolysins are bacteriolytic enzymes of bacteriophages, and a promising group of enzymes with antibacterial properties.
Olga N. Koposova +2 more
doaj +1 more source
Effect Probiotics on immune system modulation and wound Healing. ABSTRACT Introduction Burn wound infections caused by Acinetobacter baumannii remain a critical clinical challenge due to its extensive multidrug resistance, particularly against carbapenems.
Zeinab Fagheei Aghmiyuni +6 more
wiley +1 more source
This review introduces “Regenerative Microbiology,” a framework that uses bacterial antagonism and phage therapy to address diabetic wound dysbiosis. By activating the p40/EGFR/PI3K axis and providing a vascular‐stratified precision roadmap, this approach shifts the paradigm from antimicrobial suppression to intelligent, microbe‐driven tissue ...
Sabri Saeed Sanabani
wiley +1 more source

