Results 81 to 90 of about 4,542,677 (277)

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Stromal Cells and Extracellular Vesicles

, 2022
Stromal cells are stem cells in the bone marrow microenvironment that can ‘talk’ with neighbouring and distant cells within the bone marrow microenvironment.
Kelechi Okeke, Emmanuel Ogbodo, Arinzechukwu Ude   +2 more
core   +1 more source

The features of mesenchimal stromal cells of normal endometrium and endometrium from patients with different gynecological diseases

RUDN Journal of Medicine, 2013
This is the only experimental study that offers mechanical isolation of stromal cells from normal endometrium and endometrium from patients with adenomyosis, uterine myoma and endometrial hyperplasia.
T A Anikina, V E Radzinsky, K A Rubina, V Yu Sysoeva   +3 more
doaj  

Efficient Inhibition of Endometriosis Growth by Cepharanthine In Vitro, in Patient-Derived Endometrial Organoids, and In Vivo

Clinical and Experimental Obstetrics & Gynecology
Background:Available treatments for endometriosis remain unsatisfactory; therefore, there is an urgent demand for novel and effective therapeutic strategies. This study focused on the therapeutic effect of cepharanthine, a monomer derived from a Chinese
Wenxi Chen, Hantian Liu, Haoxuan Yang, Ying Xiong, Yang Xiang   +4 more
doaj   +1 more source

Low-grade endometrial stromal sarcoma: A report of five cases

Archives of Medicine and Health Sciences, 2018
Endometrial stromal sarcoma (ESS) is a very rare uterine tumor, composed of cells resembling endometrial stromal cells. As these tumors have indistinct clinical and radiological features, they are very rarely diagnosed preoperatively.
Saba Bashir, Prema Saldanha
doaj   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Endometrial Stromal Sarcoma Presenting As Puberty Menorrhagia [PDF]

, 2005
Endometrial stromal sarcomas are rare uterine tumours usually seen in perimenopausal females. We report here a case of low grade malignant endometrial stromal sarcoma in an adolescent girl, presenting as puberty menorrhagia.
Paul Sebastian, Prabhakaran Nair, Rema, Rema Prabhakaran Nair, Sebastian, Paul   +3 more
core  

Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis

Reproductive Biology and Endocrinology
Background Patients with endometriosis suffer with chronic pelvic pain and infertility, and from the lack of pharmacologic therapies that consistently halt disease progression. Differences in the endometrium of patients with endometriosis vs.
Julia Delenko, Xiangying Xue, Prodyot K Chatterjee, Nathaniel Hyman, Andrew J Shih, Robert P Adelson, Polona Safaric Tepes, Peter K Gregersen, Christine N Metz   +8 more
doaj   +1 more source

Metformin reduces androgen receptor and upregulates homeobox A10 expression in uterine endometrium in women with polycystic ovary syndrome

Reproductive Biology and Endocrinology, 2021
Background Polycystic ovary syndrome (PCOS) causes anovulation and is associated with a reduced clinical pregnancy rate. Metformin, which is widely used for treating PCOS, can lead to successful pregnancy by restoring the ovulation cycle and possibly ...
Miki Ohara, Hiromi Yoshida-Komiya, Miho Ono-Okutsu, Akiko Yamaguchi-Ito, Toshifumi Takahashi, Keiya Fujimori   +5 more
doaj   +1 more source

IL-15 Regulation in Human Endometrial Stromal Cells [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2002
A greater knowledge of IL-5 regulation within human endometrium is important in understanding key reproductive events and uterine Natural Killer cell function. In the present study, expression of IL-15 mRNA was shown to be up-regulated by both PGE(2) and IFN-gamma in cultures of human endometrial stromal cells (ESC).
Carolyn L, Dunn, Hilary O D, Critchley, Rodney W, Kelly   +2 more
openaire   +2 more sources