Results 81 to 90 of about 244,422 (325)

Microfluidic chip-integrated vascularized endometrial complexes: Mitochondrial function and paracrine crosstalk enhance regenerative potential

Bioactive Materials
Endometrial injury is a prevalent gynecological condition that poses a significant threat to fertility and women's health. While the current reported endometrial organoids demonstrate potential in remodeling endometrial functions, they often lack the ...
Yongdong Dai, Fanxuan Zhao, Qiuli Chen, Biya Zeng, Weijia Gu, Yi Zhang, Fangying Sun, Xinyu Wang, Xiang Lin, Na Liu, Yulu Wang, Feng Zhou, Jianhua Yang, Shangjing Xin, Ye Feng, Songying Zhang   +15 more
doaj   +1 more source

Alteration of chemokine production in bovine endometrial epithelial and stromal cells under heat stress conditions

Physiological Reports, 2020
After parturition, cows frequently develop uterine bacterial infections, resulting in the onset of endometritis. To eliminate the bacteria, bovine endometrial cells secrete chemokines, such as IL‐6 and MCP1, which attract macrophages (MΦs) to the ...
Shunsuke Sakai, Toshimitsu Hatabu, Yuki Yamamoto, Koji Kimura   +3 more
doaj   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Paeonol alleviates migration and invasion of endometrial stromal cells by reducing HIF-1α-regulated autophagy in endometriosis

Frontiers in Bioscience-Landmark, 2021
Background: Dysregulated migration and invasion of endometrial stromal cells is implicated in the pathogenesis of endometriosis. Hypoxia functions as critical microenvironmental factor that results in promotion of endometrial stromal cells migration and ...
Conghui Pang, Zhijuan Wu, Xiaoyan Xu, Wenxiu Yang, Xiaoxuan Wang, Yinghua Qi   +5 more
doaj   +1 more source

Association of endometrioid ovarian carcinoma arising from endometriosis, endometrioid endometrial carcinoma, and high-grade undifferentiated endometrial sarcoma. a case report [PDF]

, 2017
Endometriosis is a chronic disease that affects women of reproductive age. Malignant transformation in endometriosis is considered to be an unusual event, only occurring in 0.7-0.1% of cases.
Caserta, D., Di Benedetto, L., Guarino, A., Mallozzi, M.   +3 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Endometrial organoid and stromal cultures demonstrate donor-derived cellular origin of the endometrium after uterus transplantation

Frontiers in Cell and Developmental Biology
The human endometrium undergoes cyclical regeneration during the menstrual cycle, a process thought to be driven primarily by multipotent stem cells located within the basalis layer.
Lisa M. Meisl, Ingrid A. Teufel, Anjali Ralhan Singh, Annette Staebler, Melanie Henes, Sara Y. Brucker, Katharina Rall, André Koch   +7 more
doaj   +1 more source

Generation of Human Endometrial Assembloids with a Luminal Epithelium using Air–Liquid Interface Culture Methods

Advanced Science, 2023
The endometrial lining of the uterus is essential for women's reproductive health and consists of several different types of epithelial and stromal cells.
Jiwen Tian, Jie Yang, Tingwei Chen, Yu Yin, Nan Li, Yunxiu Li, Xingyu Luo, E Dong, Haoyang Tan, Yanping Ma, Tianqing Li   +10 more
doaj   +1 more source

Prokineticin 1 is up‐regulated by insulin in decidualizing human endometrial stromal cells

Journal of Cellular and Molecular Medicine, 2017
Prokineticin 1 (PROK1), a hypoxia‐regulated angiogenic factor, has emerged as a crucial regulator of embryo implantation and placentation. Dysregulation of PROK1 has been linked to recurrent pregnancy loss, pre‐eclampsia, foetal growth restriction and ...
D. Ujvari, Ivika Jakson, Cecilia Oldmark, S. Attarha, Twana Alkasalias, D. Salamon, S. Gidlöf, A. Hirschberg   +7 more
semanticscholar   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source