Results 1 to 10 of about 106,966 (240)
Characterization of winged helix domain fusion endonucleases as N6-methyladenine-dependent type IV restriction systems [PDF]
Frontiers in MicrobiologyWinged helix (wH) domains, also termed winged helix-turn-helix (wHTH) domains, are widespread in all kingdoms of life and have diverse roles. In the context of DNA binding and DNA modification sensing, some eukaryotic wH domains are known as sensors of ...
Igor Helbrecht +11 more
doaj +2 more sources
DNA targeting by compact Cas9d and its resurrected ancestor [PDF]
Nature CommunicationsType II CRISPR endonucleases are widely used programmable genome editing tools. Recently, CRISPR-Cas systems with highly compact nucleases have been discovered, including Cas9d (a type II-D nuclease).
Rodrigo Fregoso Ocampo +13 more
doaj +2 more sources
A new view of RNA: the 1989 discovery by Sidney Altman and Thomas Cech [PDF]
The Ukrainian Biochemical Journal, 2020 The 1989 Nobel Prize Laureates in Chemistry Sidney Altman and Thomas Robert Cech made one of the most important discoveries in molecular genetics. Independently of each other, they demonstrated new experimental evidence that RNA molecules can not only ...
M. V. Grigorieva +2 more
doaj +1 more source
Biomolecules, 2021 The prokaryotic Argonaute proteins (pAgos) have been reported to cleave or interfere with DNA targets in a guide-dependent or independent manner. It is often difficult to characterize pAgos in vivo due to the extreme environments favored by their hosts ...
Jiani Xing +7 more
doaj +1 more source
Molecular characterization and identification of fungi causing stern canker of oilseed rape in Serbia [PDF]
Ratarstvo i Povrtarstvo, 2017 During 2008-2010 the infected Brassica napus plant material was collected from nine localities: Karavukovo, Crvenka, Prigrevica, Subotica, Rimski Šančevi, Srbobran, Beška, Banatsko Karađorđevo, and Srpski Miletić.
Mitrović Petar +3 more
doaj +1 more source
High-Resolution Structure of the N-Terminal Endonuclease Domain of the Lassa Virus L Polymerase in Complex with Magnesium Ions [PDF]
, 2014 Lassa virus (LASV) causes deadly hemorrhagic fever disease for which there are no vaccines and limited treatments. LASV-encoded L polymerase is required for viral RNA replication and transcription.
Dong, Changjiang +6 more
core +8 more sources
Recent insights into the structure and function of coronavirus ribonucleases
FEBS Open Bio, 2022 Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response.
Meredith N. Frazier +4 more
doaj +1 more source
Biomolecules, 2023 Programmable endonucleases, such as Cas (Clustered Regularly-Interspaced Short Repeats-associated proteins) and prokaryotic Argonaute (pAgo), depend on base pairing of the target DNA with the guide RNA or DNA to cleave DNA strands.
Xingchen Xiong +3 more
doaj +1 more source
Sensors, 2022 Restriction endonucleases are expressed in all bacteria investigated so far and play an essential role for the bacterial defense against viral infections.
Kamilla Vandsø Petersen +11 more
doaj +1 more source
IUCrJ, 2018 The Arenaviridae family, together with the Bunyaviridae and Orthomyxoviridae families, is one of the three negative-stranded RNA viral families that encode an endonuclease in their genome.
Magali Saez-Ayala +5 more
doaj +1 more source