Results 21 to 30 of about 60,825 (304)
Enzymatic cleavage of type II restriction endonucleases on the 2'-O-methyl nucleotide and phosphorothioate substituted DNA. [PDF]
PLoS ONE, 2013 The effects of nucleotide analogue substitution on the cleavage efficiencies of type II restriction endonucleases have been investigated. Six restriction endonucleases (EcoRV, SpeI, XbaI, XhoI, PstI and SphI) were investigated respectively regarding ...
Guojie Zhao +5 more
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New Insights Into DNA Repair Revealed by NucS Endonucleases From Hyperthermophilic Archaea
Frontiers in Microbiology, 2020 Hyperthermophilic Archaea (HA) thrive in high temperature environments and their genome is facing severe stability challenge due to the increased DNA damage levels caused by high temperature.
Likui Zhang +5 more
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Viruses, 2023 Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA (DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand (endonucleases) or from the end (exonucleases) [...]
Zhengqiang Wang, Robert J. Geraghty
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Annual Review of Biochemistry, 2013 First discovered as a structure-specific endonuclease that evolved to cut at the base of single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component of cellular DNA metabolism. Substrate specificity allows FEN1 to process intermediates of Okazaki fragment maturation, long-patch base excision repair, telomere maintenance ...
Lata, Balakrishnan, Robert A, Bambara
openaire +2 more sources
Mobile DNA elements in T4 and related phages
Virology Journal, 2010 Mobile genetic elements are common inhabitants of virtually every genome where they can exert profound influences on genome structure and function in addition to promoting their own spread within and between genomes.
Belfort Marlene +2 more
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Frontiers in Microbiology, 2022 Strand-specific DNA nicking endonucleases (NEases) typically nick 3–7 bp sites. Our goal is to engineer infrequent NEase with a >8 bp recognition sequence.
Shuang-yong Xu
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Genes and Environment, 2017 Apurinic/apyrimidinic (AP) sites are one of the most frequent DNA lesions. AP sites inhibit transcription and DNA replication, and induce cell death. AP endonucleases are key enzymes in AP site repair. Several types of AP endonucleases have been reported,
Masafumi Funakoshi +3 more
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Sequence-specific DNA nicking endonucleases
Biomolecular Concepts, 2015 A group of small HNH nicking endonucleases (NEases) was discovered recently from phage or prophage genomes that nick double-stranded DNA sites ranging from 3 to 5 bp in the presence of Mg2+ or Mn2+.
Xu Shuang-yong
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Structure-Specific Endonucleases in DNA Repair
CHIMIA, 2009 Nucleotide excision repair (NER) is an essential DNA repair pathway that addresses a variety of DNA lesions formed by UV light, environmental mutagens and agents used in cancer chemotherapy.
Orlando D. Schärer
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F-CphI represents a new homing endonuclease family using the Endo VII catalytic motif
Mobile DNA, 2018 Background There are six known families of homing endonucleases, LAGLIDADG, GIY-YIG, HNH, His-Cys box, PD-(D/E)-XK, and EDxHD, which are characterized by their conserved residues.
Xiaoting Fang +3 more
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