Subnuclear Relocalization of Structure-Specific Endonucleases in Response to DNA Damage
Cell Reports, 2017 Structure-specific endonucleases contribute to the maintenance of genome integrity by cleaving DNA intermediates that need to be resolved for faithful DNA repair, replication, or recombination.
Irene Saugar +2 more
doaj +1 more source
Apurinic/apyrimidinic endonucleases of Mycobacterium tuberculosis protect against DNA damage but are dispensable for the growth of the pathogen in guinea pigs. [PDF]
PLoS ONE, 2014 In host cells, Mycobacterium tuberculosis encounters an array of reactive molecules capable of damaging its genome. Non-bulky DNA lesions are the most common damages produced on the exposure of the pathogen to reactive species and base excision repair ...
Rupangi Verma Puri +2 more
doaj +1 more source
Two restriction endonucleases [PDF]
Biochemistry and Molecular Biology Education, 2006 AbstractTerms to be familiar with before you start to solve the test: restriction endonucleases; palindromic sequences; blunt ends; cohesive (“sticky”) ends; in vitro DNA synthesis; radioactive nucleotide precursors; template‐primer complexes; DNA ligation.
openaire +2 more sources
A protein architecture guided screen for modification dependent restriction endonucleases [PDF]
, 2019 Modification dependent restriction endonucleases (MDREs) often have separate catalytic and modification dependent domains. We systematically looked for previously uncharacterized fusion proteins featuring a PUA or DUF3427 domain and HNH or PD-(D/E)XK ...
Czapinska, Honorata +8 more
core +1 more source
Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings
Advanced Materials, EarlyView.Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed +9 more
wiley +1 more source
Endonucleases induced TRAIL-insensitive apoptosis in ovarian carcinoma cells
, 2009 TRAIL induced apoptosis of tumor cells is currently entering phase II clinical settings, despite the fact that not all tumor types are sensitive to TRAIL.
Geel, Tessa M. +12 more
core +1 more source
Advanced Materials, EarlyView.A hierarchically structured metal–organic framework (eMIL) is shown to host the complete six‐enzyme biosynthesis pathway for the anti‐cancer pigment violacein, reshaping reaction dynamics and multiplying in vitro yields. eMIL nanoreactors deliver this reconstituted bacterial multi‐protein system into mammalian cells, where cell‐derived substrates and ...
Ainur Sharip +12 more
wiley +1 more source
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes [PDF]
, 2009 For the full list of authors, see article on the publisher’s website or in PubMed.A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories
Marinus, Martin G., Roberts, Richard J.
core +2 more sources
Novel Cloning Method for Recombinant Adenovirus Construction in Escherichia coli
BioTechniques, 1999 pAdvantage is a rapid cloning system for generating recombinant adenoviruses. The system is based on manipulating the fulllength adenovirus genome as a stable plasmid in E. coli using intron-encoded endonucleases.
David W. Souza, Donna Armentano
doaj +1 more source
DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics
Advanced Science, EarlyView.This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei +12 more
wiley +1 more source