Results 51 to 60 of about 60,825 (304)
Advanced Science, EarlyView.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
Restriction Endonucleases and Modification Methylases
, 1993 Restriction endonucleases and modification methylases offer excellent systems for studying protein-DNA interactions. The past year has seen the experimental verification of some aspects of the catalytic mechanisms of both types of enzyme.
Anderson, J. E.
core +1 more source
Advanced Science, EarlyView.An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu +8 more
wiley +1 more source
Restriction endonucleases from Bifidobacterium bifidum
, 1984 Three restriction endonucleases, BbiI, BbiII and BbiIII, have been isolated from Bifidobacterium bifidum. The recognition and cleavage specificity of BbiII was determined to be 5'-GR↓CGYC-3', identical to that of AcyI isolated from a cyanobacterium ...
Kiwaki, Mayumi +3 more
core +1 more source
Advanced Science, EarlyView.The TopCas platform utilizes an engineered DNA‐RNA chimeric circular crRNA to establish topology‐gated control over CRISPR‐Cas12a activity, enabling target‐triggered self‐catalytic amplification (preamplification‐free). This system seamlessly integrates highly sensitive molecular diagnostics with conditionally controlled gene editing, demonstrating ...
Shun Zhang +7 more
wiley +1 more source
Selfish DNA: New Abode for Homing Endonucleases
, 2002 A 30-year old conundrum concerning the genetics of T-even bacteriophages has at last been solved, the answer turning out to involve free-standing homologs of intron-encoded homing ...
David R Edgell, Edgell, David R
core +1 more source
Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance
Advanced Science, EarlyView.Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes +4 more
wiley +1 more source
Cloning and characterization of a wheat homologue of apurinic/apyrimidinic endonuclease Ape1L. [PDF]
PLoS ONE, 2014 Apurinic/apyrimidinic (AP) endonucleases are key DNA repair enzymes involved in the base excision repair (BER) pathway. In BER, an AP endonuclease cleaves DNA at AP sites and 3'-blocking moieties generated by DNA glycosylases and/or oxidative damage.
Botagoz Joldybayeva +7 more
doaj +1 more source
Broken Symmetry in Homing Endonucleases
, 2006 Homing DNA endonucleases are highly site-specific enzymes that initiate the transfer of mobile DNA elements. In this issue of Structure, Spiegel et al.
Gimble, Frederick S.
core +1 more source
Advanced Science, EarlyView.RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu +7 more
wiley +1 more source