Results 31 to 40 of about 64,056 (293)
Frontiers in Microbiology, 2022 Strand-specific DNA nicking endonucleases (NEases) typically nick 3–7 bp sites. Our goal is to engineer infrequent NEase with a >8 bp recognition sequence.
Shuang-yong Xu
doaj +1 more source
Annual Review of Biochemistry, 2013 First discovered as a structure-specific endonuclease that evolved to cut at the base of single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component of cellular DNA metabolism. Substrate specificity allows FEN1 to process intermediates of Okazaki fragment maturation, long-patch base excision repair, telomere maintenance ...
Lata, Balakrishnan, Robert A, Bambara
openaire +2 more sources
Broken Symmetry in Homing Endonucleases [PDF]
, 2006 Homing DNA endonucleases are highly site-specific enzymes that initiate the transfer of mobile DNA elements. In this issue of Structure, Spiegel et al.
Gimble, Frederick S.
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Selfish DNA: New Abode for Homing Endonucleases [PDF]
, 2002 A 30-year old conundrum concerning the genetics of T-even bacteriophages has at last been solved, the answer turning out to involve free-standing homologs of intron-encoded homing ...
David R Edgell, Edgell, David R
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Sequence-specific DNA nicking endonucleases
Biomolecular Concepts, 2015 A group of small HNH nicking endonucleases (NEases) was discovered recently from phage or prophage genomes that nick double-stranded DNA sites ranging from 3 to 5 bp in the presence of Mg2+ or Mn2+.
Xu Shuang-yong
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Structure-Specific Endonucleases in DNA Repair
CHIMIA, 2009 Nucleotide excision repair (NER) is an essential DNA repair pathway that addresses a variety of DNA lesions formed by UV light, environmental mutagens and agents used in cancer chemotherapy.
Orlando D. Schärer
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F-CphI represents a new homing endonuclease family using the Endo VII catalytic motif
Mobile DNA, 2018 Background There are six known families of homing endonucleases, LAGLIDADG, GIY-YIG, HNH, His-Cys box, PD-(D/E)-XK, and EDxHD, which are characterized by their conserved residues.
Xiaoting Fang +3 more
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Frontiers in Microbiology, 2020 Modification dependent restriction endonucleases (MDREs) restrict modified DNA, typically with limited sequence specificity (∼2–4 bp). Here, we focus on MDREs that have an SRA and/or SBD (sulfur binding domain) fused to an HNH endonuclease domain ...
Thomas Lutz +10 more
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SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Cell Reports, 2013 SLX4 interacts with several endonucleases to resolve structural barriers in DNA metabolism. SLX4 also interacts with telomeric protein TRF2 in human cells. The molecular mechanism of these interactions at telomeres remains unknown.
Bingbing Wan +13 more
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Computational approaches to restriction endonucleases
, 2003 Type II restriction endonucleases catalyze phosphodiester bond hydrolysis in bacteria to protect the host cell from invading phage DNA. Due to their exquisite sequence selectivity type II restriction endonucleases serve as excellent model systems for ...
Simon I., Osman R., Fuxreiter M.
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