Results 91 to 100 of about 35,058 (249)

The Supporting Scaffold as a Structural Module for Plant Cystatin Design

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein engineering approaches have been proposed to improve the inhibitory potency of cystatins against plant pest digestive Cys proteases, typically involving point mutations in the N‐terminal trunk or inhibitory loops known to interact with the target protease.
Jonathan Tremblay, Kristina LeBreux, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +4 more
wiley   +1 more source

Aza-peptidyl Michael Acceptors. A New Class of Potent and Selective Inhibitors of Asparaginyl Endopeptidases (Legumains) from Evolutionarily Diverse Pathogens

, 2016
Aza-peptide Michael acceptors with the general structure of Cbz-Ala-Ala-AAsn-trans-CHCHCOR are a new class of inhibitors specific for the asparaginyl endopeptidases (AE) (legumains).
Karen Ellis James (2439814), James H. McKerrow (113918), Marion G. Götz (2439817), Jan Dvořák (2335264), Conor R. Caffrey (113916), Amritha Seshaadri (2439811), Elizabeth Hansell (203763), James C. Powers (2268154), Petr Kopáček (2439820), Daniel Sojka (83126)   +9 more
core   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases

, 1994
The insulin storage granule of the pancreatic beta cell is assembled within the trans Golgi network from around 50 or so gene products many of which are synthesized coordinately with the major component, proinsulin.
Hutton, John-Charles
core   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

Amino acid residues modulating the activities of staphylococcal glutamyl endopeptidases. [PDF]

, 2010
The glutamyl endopeptidase family of enzymes from staphylococci has been shown to be important virulence determinants of pathogenic family members, such as Staphylococcus aureus. Previous studies have identified the N-terminus and residues from positions
Takayuki K. Nemoto, Yuko Ohara-Nemoto, Ohara-Nemoto, Yuko, Shigenobu Kimura, Ono, Toshio, Takeshi Kobayakawa, Hisami Okawara, Toshio Ono, Yu Shimoyama, Baba, Tomomi T, Nemoto, Takayuki K, Kobayakawa, Takeshi, Tomomi T. Baba, Kimura, Shigenobu, Shimoyama, Yu, Okawara, Hisami   +15 more
core   +1 more source

Transcription profiles of hydrogenases related genes in the cyanobacterium Lyngbya majuscula CCAP 1446/4

BMC Microbiology, 2009
Background Lyngbya majuscula CCAP 1446/4 is a N2-fixing filamentous nonheterocystous strain that contains two NiFe-hydrogenases: an uptake (encoded by hupSL) and a bidirectional enzyme (encoded by hoxEFUYH).
Moradas-Ferreira Pedro, Pinto Filipe, Ferreira Daniela, Mendes Marta V, Tamagnini Paula   +4 more
doaj   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Genetic interaction mapping reveals functional relationships between peptidoglycan endopeptidases and carboxypeptidases.

PLoS Genetics
Peptidoglycan (PG) is the main component of the bacterial cell wall; it maintains cell shape while protecting the cell from internal osmotic pressure and external environmental challenges.
Manuela Alvarado Obando, Diego Rey-Varela, Felipe Cava, Tobias Dörr   +3 more
doaj   +1 more source

Immunoglobulin A protease from Sutterella wadsworthensis modifies outcome of infection with Campylobacter jejuni and is associated with microbiome diversity

Gut Microbes
Sutterella wadsworthensis is an enigmatic member of the microbiota, previously reported to be present in healthy humans yet also associated with certain gut diseases and their therapeutic outcomes. Here, we report on S.
Marwan E. Majzoub, Fernando S. Santiago, Shreeya S. Raich, Prakruti Sirigeri, Isidora Simovic, Nicodemus Tedla, Nadeem O. Kaakoush   +6 more
doaj   +1 more source