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Genetic Overlap Among Intelligence and Other Candidate Endophenotypes for Schizophrenia

Biological Psychiatry, 2009
A strategy to improve genetic studies of schizophrenia involves the use of endophenotypes. Information on overlapping genetic contributions among endophenotypes may provide additional power, reveal biological pathways, and have practical implications for
Behrooz Z. Alizadeh, Roel Ophoff, Chantal Kemner   +2 more
exaly   +2 more sources

Neurobiological candidate endophenotypes of social anxiety disorder

Neuroscience and Biobehavioral Reviews, 2016
Social anxiety disorder (SAD) is a disabling psychiatric disorder with a complex pathogenesis. Studies indicate a genetic component in the development of SAD, but the search for genetic mechanisms underlying this vulnerability is complicated.
Janna Marie Bas-Hoogendam, Pieter Michiel Westenberg   +1 more
exaly   +2 more sources

Alzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment

Alzheimer's and Dementia, 2016
IntroductionWe evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).MethodsWe selected 1730 MCI patients from four independent data sets.
Wiesje van der Flier, Philip Scheltens, Steffen Wolfsgruber   +2 more
exaly   +3 more sources

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Endophenotyping

Neurology, 2005
Neuroimaging-based endophenotyping is becoming popular. The aim is to discover markers for altered CNS gene expression in nonmanifesting gene carriers for illnesses with reduced penetrance, preclinical gene carriers for illnesses with a late onset, and even healthy subjects with allelic variants possibly related to an increased susceptibility for ...
Meunier, Sabine, Hallett, Mark
openaire   +3 more sources