Results 171 to 180 of about 16,681 (209)
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2020
Since Gottesman introduced the concept of endophenotypes in schizophrenia research, the endophenotype strategy for understanding the genetics of schizophrenia has been used widely. Endophenotypes are wide-ranging laboratory-based quantitative measures from gene transcripts to neurocognition that show deficits in schizophrenia patients and their first ...
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Since Gottesman introduced the concept of endophenotypes in schizophrenia research, the endophenotype strategy for understanding the genetics of schizophrenia has been used widely. Endophenotypes are wide-ranging laboratory-based quantitative measures from gene transcripts to neurocognition that show deficits in schizophrenia patients and their first ...
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Endophenotypes as a measure of suicidality
Journal of Applied Genetics, 2012Suicide is thought to result from the harmful interaction of multiple factors that have social, environmental, neurobiological, and genetic backgrounds. Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia, or ...
Dimitry A, Chistiakov +2 more
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2021
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis and very wide clinical phenotypes. To date, a large variety of clinical phenotypes have been grouped into a single diagnosis, and a single therapeutic approach has been used for AD patients with different clinical phenotypes without considering ...
Kwang Hoon Lee, Chang Ook Park
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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis and very wide clinical phenotypes. To date, a large variety of clinical phenotypes have been grouped into a single diagnosis, and a single therapeutic approach has been used for AD patients with different clinical phenotypes without considering ...
Kwang Hoon Lee, Chang Ook Park
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Endophenotypes in bipolar disorder†
American Journal of Medical Genetics, 2002AbstractThe search for genes in bipolar disorder has provided numerous genetic loci that have been linked to susceptibility to developing the disorder. However, because of the genetic heterogeneity inherent in bipolar disorder, additional strategies may need to be employed to fully dissect the genetic underpinnings.
Robert H, Lenox +2 more
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Neurocognitive endophenotypes for bipolar disorder
Bipolar Disorders, 2008Objectives: Neurocognitive deficits have been proposed as vulnerability markers or endophenotypes for the development of bipolar I disorder (BD I). However, few research studies have examined whether neurocognitive deficits also exist in first‐degree relatives of individuals with BD I.Methods: This prospective study examined neurocognitive function ...
Linda V, Frantom +2 more
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[Temperamental endophenotypes].
L'Encephale, 2013Temperament has been defined as the heritable biologically determined core of personality that remains stable throughout the life span and establishes the baseline level of reactivity, mood, and energy of a person. If the link between temperament and mental disorder goes back to the Greco-Roman medicine, Kraepelin was among the first authors to pay ...
J-M, Azorin +10 more
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Schizophrenia endophenotypes as treatment targets
Expert Opinion on Therapeutic Targets, 2007Schizophrenia is a complex disorder that encompasses several clinical symptom domains and functional impairments. Existing treatments are meager, effective only against positive symptoms without benefiting negative symptoms and functional impairments. The drug discovery process has focused mostly on targeting D2 dopamine receptors.
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Evaluating brain structure traits as endophenotypes using polygenicity and discoverability
Human Brain Mapping, 2022Nana Matoba +2 more
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