Results 11 to 20 of about 194,866 (319)
Journal of Inflammation, 2023 Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD).
Yue Yu +9 more
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Endoplasmic Reticulum Stress in Malignancy [PDF]
Cancer Cell, 2014 The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival.
Clarke, Hanna J +3 more
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Endoplasmic reticulum stress and pulmonary hypertension
Pulmonary Circulation, 2020 Pulmonary hypertension is a fatal disease of which pulmonary vasculopathy is the main pathological feature resulting in the mean pulmonary arterial pressure higher than 25 mmHg.
Yanan Hu +5 more
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Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. [PDF]
PLoS ONE, 2014 Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition.
Evelyn Zeindl-Eberhart +7 more
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Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?
Frontiers in Pharmacology, 2023 Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses.
Kimia Keylani +18 more
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Structural Controllability to Unveil Hidden Regulation Mechanisms in Unfolded Protein Response: the Role of Network Models [PDF]
, 2023 The Unfolded Protein Response is the cell mechanism for maintaining the balance of properly folded proteins in the endoplasmic reticulum , the specialized cellular compartment. Although it is largely studied from a biological point of view, much of the literature lacks a quantitative analysis of such a central signaling pathway. In this work, we aim to
arxiv +1 more source
Construction of the endoplasmic reticulum. [PDF]
The Journal of cell biology, 1989 To study the construction of the ER, we used the microtubule-disrupting drug nocodazole to induce the complete breakdown of ER structure in living cells followed by recovery in drug-free medium, which regenerates the ER network within 15 min. Using the fluorescent dye 3,3'-dihexyloxacarbocyanine iodide to visualize the ER, we have directly observed the
Michael A. J. Ferguson +2 more
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Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury
Neural Regeneration Research, 2018 Apoptosis after traumatic brain injury has been shown to be a major factor influencing prognosis and outcome. Endoplasmic reticulum stress may be involved in mitochondrial mediated neuronal apoptosis. Therefore, endoplasmic reticulum stress has become an
Hong-Ping Tan +4 more
doaj +1 more source
KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata. [PDF]
PLoS ONE, 2016 The maintenance of cell wall integrity in fungi is required for normal cell growth, division, hyphae formation, and antifungal tolerance. We observed that endoplasmic reticulum stress regulated cell wall integrity in Candida glabrata, which possesses ...
Yutaka Tanaka +7 more
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Endoplasmic reticulum stress and apoptosis [PDF]
Cellular and Molecular Biology Letters, 2006 AbstractCell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death
Jitka Faitova +3 more
openaire +3 more sources