Results 11 to 20 of about 605,400 (330)

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources

Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism [PDF]

, 2008
The B chain of ricin was expressed and delivered to the endoplasmic reticulum of tobacco protoplasts where it disappeared with time in a manner consistent with degradation. This turnover did not occur in the vacuoles or upon secretion.
Asher, Bakker, Barlowe, Barlowe, Benatti, Blanchard, Brandizzi, Brauer, Braun, Carter, Contento, d'Enfert, d'Enfert, de Virgilio, Di Cola, Di Cola, Donoso, Ellgaard, Endo, Feiler, Fenteany, Ferrini, Frigerio, Frigerio, Frigerio, Frigerio, Frigerio, Gillespie, Glas, Hellens, Hong, Jarosch, Jolliffe, Jolliffe, Katiyar, Kisselev, Kong, Lord, Lord, Loureiro, Ma, Maliga, Marshall, Meng, Meusser, Muller, Nebenfuhr, Nuttall, Nuttall, Parodi, Pedrazzini, Phillipson, Pimpl, Rancour, Reichel, Roberts, Romisch, Saint-Jore-Dupas, Schmitz, Schmitz, Sheng, Smith, Speranza, Tabe, Taiz, Tamura, Tolchinsky, Tormakangas, Tsai, Vitale, Wales, Ye, Ye, Yuk   +73 more
core   +2 more sources

Research Progress on Endoplasmic Reticulum Stress-Mediated Apoptosis and Its Regulatory Mechanism on Muscle Tenderization [PDF]

Shipin Kexue
The endoplasmic reticulum is a key site for calcium storage, lipid synthesis, protein synthesis, transport and folding, and it performs several critical biological functions.
LI Chenlong, LUO Yulong, DONG Yushan, DU Xuerong, YAO Lili, HOU Yanru, WANG Jiayu, XU Shengyun
doaj   +1 more source

Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. [PDF]

PLoS ONE, 2014
Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition.
Evelyn Zeindl-Eberhart, Lydia Brandl, Sibylle Liebmann, Steffen Ormanns, Silvio K Scheel, Thomas Brabletz, Thomas Kirchner, Andreas Jung   +7 more
doaj   +1 more source

THE ENDOPLASMIC RETICULUM [PDF]

The Journal of Cell Biology, 1956
and (b) the vesicular character of its component elements, were already clearly noted in its first description. In subsequent papers, Porter and his collaborators described the preferential concentration of the vesicular elements of the reticulum in the endoplasm, and their scarcity or absence in the supposedly exoplasmic periphery of the cytoplasm (2,
openaire   +2 more sources

Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]

, 2017
Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio, Tokatlidis, Konstantinos   +1 more
core   +1 more source

Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury

Neural Regeneration Research, 2018
Apoptosis after traumatic brain injury has been shown to be a major factor influencing prognosis and outcome. Endoplasmic reticulum stress may be involved in mitochondrial mediated neuronal apoptosis. Therefore, endoplasmic reticulum stress has become an
Hong-Ping Tan, Qiang Guo, Gang Hua, Jun-Xi Chen, Jun-Chao Liang   +4 more
doaj   +1 more source

Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?

Frontiers in Pharmacology, 2023
Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses.
Kimia Keylani, Fariba Arbab Mojeni, Amirmohammad Khalaji, Asma Rasouli, Dlnya Aminzade, Mohammad Amin Karimi, Pantea Majma Sanaye, Nazanin Khajevand, Nasrin Nemayandeh, Mohadeseh Poudineh, Mehdi Azizabadi Farahani, Mohammad Ali Esfandiari, Sepehr Haghshoar, Ali Kheirandish, Erfan Amouei, Amir Abdi, Arash Azizinezhad, Afshin Khani, Niloofar Deravi   +18 more
doaj   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata. [PDF]

PLoS ONE, 2016
The maintenance of cell wall integrity in fungi is required for normal cell growth, division, hyphae formation, and antifungal tolerance. We observed that endoplasmic reticulum stress regulated cell wall integrity in Candida glabrata, which possesses ...
Yutaka Tanaka, Masato Sasaki, Fumie Ito, Toshio Aoyama, Michiyo Sato-Okamoto, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Nobuyuki Shibata   +7 more
doaj   +1 more source