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THE ENDOPLASMIC RETICULUM [PDF]
The Journal of Cell Biology, 1956 and (b) the vesicular character of its component elements, were already clearly noted in its first description. In subsequent papers, Porter and his collaborators described the preferential concentration of the vesicular elements of the reticulum in the endoplasm, and their scarcity or absence in the supposedly exoplasmic periphery of the cytoplasm (2,
George E. Palade
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Endoplasmic Reticulum Stress in Malignancy [PDF]
Cancer Cell, 2014 The combination of relative nutrient deprivation and dysregulation of protein synthesis make malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which results from protein misfolding within the secretory pathway, has a profound effect on cancer cell proliferation and survival.
Clarke, Hanna J +3 more
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Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative Diseases
International Journal of Molecular Sciences, 2020 The endoplasmic reticulum (ER) is an important organelle involved in protein quality control and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress, followed by an adaptive response via the activation of the unfolded ...
Rose Ghemrawi, Mostafa Khair
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Construction of the endoplasmic reticulum. [PDF]
The Journal of cell biology, 1989 To study the construction of the ER, we used the microtubule-disrupting drug nocodazole to induce the complete breakdown of ER structure in living cells followed by recovery in drug-free medium, which regenerates the ER network within 15 min. Using the fluorescent dye 3,3'-dihexyloxacarbocyanine iodide to visualize the ER, we have directly observed the
Michael A. J. Ferguson +2 more
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Research Progress on Endoplasmic Reticulum Stress-Mediated Apoptosis and Its Regulatory Mechanism on Muscle Tenderization [PDF]
Shipin KexueThe endoplasmic reticulum is a key site for calcium storage, lipid synthesis, protein synthesis, transport and folding, and it performs several critical biological functions.
LI Chenlong, LUO Yulong, DONG Yushan, DU Xuerong, YAO Lili, HOU Yanru, WANG Jiayu, XU Shengyun
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Epithelial-mesenchymal transition induces endoplasmic-reticulum-stress response in human colorectal tumor cells. [PDF]
PLoS ONE, 2014 Tumor cells are stressed by unfavorable environmental conditions like hypoxia or starvation. Driven by the resulting cellular stress tumor cells undergo epithelial-mesenchymal transition.
Evelyn Zeindl-Eberhart +7 more
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Inhibition of endoplasmic reticulum stress alleviates secondary injury after traumatic brain injury
Neural Regeneration Research, 2018 Apoptosis after traumatic brain injury has been shown to be a major factor influencing prognosis and outcome. Endoplasmic reticulum stress may be involved in mitochondrial mediated neuronal apoptosis. Therefore, endoplasmic reticulum stress has become an
Hong-Ping Tan +4 more
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Endoplasmic Reticulum Stress and Cancer [PDF]
Journal of Cancer Prevention, 2014 The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death.
Raj Kumar Yadav +3 more
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Endoplasmic reticulum as a target in cardiovascular diseases: Is there a role for flavonoids?
Frontiers in Pharmacology, 2023 Flavonoids are found in natural health products and plant-based foods. The flavonoid molecules contain a 15-carbon skeleton with the particular structural construction of subclasses.
Kimia Keylani +18 more
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Endoplasmic reticulum stress and apoptosis [PDF]
Cellular and Molecular Biology Letters, 2006 AbstractCell death is an essential event in normal life and development, as well as in the pathophysiological processes that lead to disease. It has become clear that each of the main cellular organelles can participate in cell death signalling pathways, and recent advances have highlighted the importance of the endoplasmic reticulum (ER) in cell death
Jitka Faitova +3 more
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